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Keywords: synthetic lethality
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Biochem Soc Trans (2021) 49 (4): 1489–1503.
Published: 25 August 2021
... alterations. Here, we review recent progress in understanding the composition, assembly, structure, and function of BAF complexes, and the consequences of their disease-associated mutations. Furthermore, we highlight intra-complex subunit dependencies and synthetic lethal interactions, which have emerged...
Includes: Supplementary data
Biochem Soc Trans (2014) 42 (1): 82–88.
Published: 23 January 2014
... potency were developed as chemo- and radio-sensitizers and first entered clinical trial in cancer patients in 2003. However, it was the revelation in 2005 that they were synthetically lethal in cells with DNA repair defects, found almost exclusively in some tumours, that led to a major interest...