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Keywords: synthetic biology
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221542.
Published: 01 September 2023
... [ 40 ]. Modifications to affinity or specificity are typically done with tools from protein or DNA engineering techniques [ 16 ]. While not specifically aimed at biosensor design, a large portion of current work at the interface of AI and synthetic biology focuses on protein engineering [ 41 , 42...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1505–1516.
Published: 28 October 2022
... 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 CRISPR designer Cas9 enzyme design gene editing protein engineering synthetic biology The ability to manipulate genes has played a pivotal role in defining their functions...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 987–1001.
Published: 11 April 2022
... BY) . biocatalysts biofuels metabolic engineering microbiology synthetic biology Since the industrial revolution, the use of fossilised biomass for energy and chemicals has altered the natural carbon (C) cycle, with major impacts now felt worldwide [ 1 ]. Liquid transport fuels are a convenient form...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 203–215.
Published: 13 January 2021
... advancements in NRPS and RiPPs combinatorial biosynthesis. How far are we in generating a combinatorial toolbox, which ‘tools’ and approaches are available and will natural product synthetic biology be able to create compounds that combat multi-drug resistance? As many RiPPs natively display potent...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1979–1993.
Published: 23 September 2020
... engineering endeavors in every aspect of life, and biology is no exception. Synthetic biology is a promising multidisciplinary field that uses concepts from engineering (such as abstraction, standardization and modularity) to design and create, rather than to only observe and perturb, biological systems...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1473–1492.
Published: 24 August 2020
... system membrane proteins protein reconstitution synthetic biology Lipid membranes are found in all living cells and provide several vital functions. Not only do they protect the organism from a potentially hostile environment, but they also allow chemical compartmentalization, e.g. reducing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1367–1378.
Published: 06 July 2020
...’ alternative to that of chemical methods, and this approach is about to undergo a renaissance thanks to synthetic biology. Synthetic biology couples molecular genetics with traditional engineering principles, incorporating a modular and standardised practice into the assembly of genetic parts. This has allowed...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 113–122.
Published: 20 February 2020
...Lionel Clarke; Richard Kitney Since the beginning of the 21st Century, synthetic biology has established itself as an effective technological approach to design and engineer biological systems. Whilst research and investment continues to develop the understanding, control and engineering...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1773–1780.
Published: 05 December 2019
... on behalf of the Biochemical Society 2019 expanded genetic code oligomerization protein complexes protein engineering structural biology synthetic biology The vast expanse of protein sequence space has been the driving force behind molecular evolution, with the quaternary structure adding...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1279–1289.
Published: 23 October 2019
...Patrícia Apura; Susana Domingues; Sandra C. Viegas; Cecília M. Arraiano The revolution of genomics and growth of systems biology urged the creation of synthetic biology, an engineering discipline aiming at recreating and reprogramming cellular functions for industrial needs. There has been a huge...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1233–1245.
Published: 11 October 2019
.... As well as the practical benefits of miniaturisation and simplicity for understanding sequence-structure-function relationships, minimalism should also support the abstract conceptualisation of membrane proteins as modular components for synthetic biology. These ideas are illustrated with selected...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (3): 765–777.
Published: 24 June 2019
.... This mini-review gives an overview of important synthetic biology developments in the bioengineering of BMCs and a perspective on future directions in the field. Correspondence: Stefanie Frank ( stefanie.frank@ucl.ac.uk ) 26 3 2019 9 5 2019 22 5 2019 © 2019 The Author(s...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 449–460.
Published: 19 February 2019
... 21 1 2019 28 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 phage phage tail-like bacteriocin protein engineering receptor-binding protein synthetic biology tailocin Bacteriophages (phages) are bacteria...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1605–1613.
Published: 04 December 2018
... systems. These examples of phage-based antimicrobial approaches are highlighted in the following sections. bacteriophages biocontrol agents synthetic biology Food supplies from agriculture and aquaculture will need to intensify as a result of the anticipated growth in the human population...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (3): 785–791.
Published: 15 June 2017
...Simon J. Moore; James T. MacDonald; Paul S. Freemont Cell-free transcription–translation is an expanding field in synthetic biology as a rapid prototyping platform for blueprinting the design of synthetic biological devices. Exemplar efforts include translation of prototype designs into medical...
Articles
Chris J. Myers, Jacob Beal, Thomas E. Gorochowski, Hiroyuki Kuwahara, Curtis Madsen, James Alastair McLaughlin, Göksel Mısırlı, Tramy Nguyen, Ernst Oberortner, Meher Samineni, Anil Wipat, Michael Zhang, Zach Zundel
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (3): 793–803.
Published: 15 June 2017
...Chris J. Myers; Jacob Beal; Thomas E. Gorochowski; Hiroyuki Kuwahara; Curtis Madsen; James Alastair McLaughlin; Göksel Mısırlı; Tramy Nguyen; Ernst Oberortner; Meher Samineni; Anil Wipat; Michael Zhang; Zach Zundel A synthetic biology workflow is composed of data repositories that provide...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (3): 781–783.
Published: 15 June 2017
...Angel Goñi-Moreno; Anil Wipat; Natalio Krasnogor The Centre for Synthetic Biology and the Bioeconomy (CSBB) brings together a far-reaching multidisciplinary community across all Newcastle University's faculties — Medical Sciences, Science, Agriculture and Engineering, and Humanities, Arts...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (3): 585–597.
Published: 15 June 2017
...-organizing system of incredibly complex biomolecules, a marvelous dynamic that we are still attempting to unravel. Can we use what we have gleaned from biology thus far to illuminate alternative strategies for designer nanomaterial manufacturing? In the present review article, new synthetic biology efforts...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 15–26.
Published: 15 February 2017
... in vitro reconstitution membrane proteins synthetic biology vesicles The significant challenge of maintaining membrane proteins in their native state, preserving their structure and function in vitro , calls for experimental tools that facilitate their study and handling, which are being...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1165–1175.
Published: 15 August 2016
... subset of potential chemistries. A vast amount of knowledge has been accrued through describing and characterizing enzymes, biological processes and organisms. Nevertheless, much remains to be understood about the natural world. One of the goals in Synthetic Biology is to recapitulate biological...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1158–1164.
Published: 15 August 2016
... science goals for heavy radiation and thermal protection. Biology has the potential to solve these problems because life can replicate and repair itself, and perform a wide variety of chemical reactions including making food, fuel and materials. Synthetic biology enhances and expands life's evolved...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 687–688.
Published: 09 June 2016
...Stephen Chambers; Richard Kitney; Paul Freemont The establishment of a DNA synthesis and construction foundry at Imperial College in London heralds a new chapter in the development of synthetic biology to meet new global challenges. The Foundry employs the latest technology to make the process...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 684–686.
Published: 09 June 2016
...Alan Burbidge; Nigel P. Minton Synthetic Biology Research Centre (SBRC)-Nottingham ( www.sbrc-nottingham.ac.uk ) was one of the first three U.K. university-based SBRCs to be funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Engineering and Physical Sciences Research...
Articles
Pablo Carbonell, Andrew Currin, Mark Dunstan, Donal Fellows, Adrian Jervis, Nicholas J.W. Rattray, Christopher J. Robinson, Neil Swainston, Maria Vinaixa, Alan Williams, Cunyu Yan, Perdita Barran, Rainer Breitling, George Guo-Qiang Chen, Jean-Loup Faulon, Carole Goble, Royston Goodacre, Douglas B. Kell, Rosalind Le Feuvre, Jason Micklefield, Nigel S. Scrutton, Philip Shapira, Eriko Takano, Nicholas J. Turner
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 675–677.
Published: 09 June 2016
.... Kell; Rosalind Le Feuvre; Jason Micklefield; Nigel S. Scrutton; Philip Shapira; Eriko Takano; Nicholas J. Turner The Manchester Synthetic Biology Research Centre (SYNBIOCHEM) is a foundry for the biosynthesis and sustainable production of fine and speciality chemicals. The Centre's integrated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 731–737.
Published: 09 June 2016
...James Gilman; John Love The judicious choice of promoter to drive gene expression remains one of the most important considerations for synthetic biology applications. Constitutive promoter sequences isolated from nature are often used in laboratory settings or small-scale commercial production...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 702–708.
Published: 09 June 2016
...Nicola J. Patron Synthetic biology aims to apply engineering principles to the design and modification of biological systems and to the construction of biological parts and devices. The ability to programme cells by providing new instructions written in DNA is a foundational technology of the field...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 689–691.
Published: 09 June 2016
...Kathleen R. Sedgley; Paul R. Race; Derek N. Woolfson BrisSynBio is the Bristol-based Biotechnology and Biological Sciences Research Council (BBSRC)/Engineering and Physical Sciences Research Council (EPSRC)-funded Synthetic Biology Research Centre. It is one of six such Centres in the U.K...
Articles
James R. Johnson, Rosalinda D'Amore, Simon C. Thain, Thomas Craig, Hannah V. McCue, Christiane Hertz-Fowler, Neil Hall, Anthony J.W. Hall
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 681–683.
Published: 09 June 2016
... community with easy access to the validated tools required to explore the possibilities of Synthetic Biology. 1 To whom correspondence should be addressed (email Anthony.Hall@liverpool.ac.uk ). 15 1 2016 © 2016 The Author(s) 2016 This is an open access article published...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 692–695.
Published: 09 June 2016
... ranging impact. We bring together the power of synthetic biology and systems approaches to focus on three core thematic areas: industrial biotechnology, agriculture and the environment, and medicine and healthcare. In October 2015, we opened a newly refurbished building as a physical hub for our new U.K...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 696–701.
Published: 09 June 2016
... prostheses, incorporating living cells into life-support machines). Synthetic biology is aimed mainly at engineering cells so that they can perform custom functions: applying synthetic biological approaches to tissue engineering may be one way of engineering custom structures. In this article, we outline...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 716–722.
Published: 09 June 2016
... species including the green alga Chlamydomonas reinhardtii and the diatom Phaeodactylum tricornutum , although for both species there are bottlenecks to be overcome to allow rapid and predictable genetic manipulation. One approach to do this would be to apply the principles of synthetic biology...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 723–730.
Published: 09 June 2016
...Yuval Elani The quest to construct artificial cells from the bottom-up using simple building blocks has received much attention over recent decades and is one of the grand challenges in synthetic biology. Cell mimics that are encapsulated by lipid membranes are a particularly powerful class...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1159–1165.
Published: 23 September 2013
...Shiksha Mantri; K. Tanuj Sapra Realization of a functional artificial cell, the so-called protocell, is a major challenge posed by synthetic biology. A subsequent goal is to use the protocellular units for the bottom-up assembly of prototissues. There is, however, a looming chasm in our knowledge...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1195–1200.
Published: 23 September 2013
... on. bacterial enhancer binding protein cell signalling chimaeric protein protein engineering synthetic biology two-component signalling system © 2013 The author(s) 2013 This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) ( http...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1146–1151.
Published: 23 September 2013
... of synthetic biology, it is now possible to design and implement biosensors that consist of biological macromolecules and are able to report on the intracellular environment of cells. The use of fluorescent reporter signals allows non-invasive, non-destructive and online monitoring of the culture, which...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1201–1205.
Published: 23 September 2013
... properties and an inherently large change in emission ratio. The modularity of this approach should make it easily transferable to other applications of protein switches in fields ranging from synthetic biology, optogenetics and molecular diagnostics. 1 email m.merkx@tue.nl 2 7 2013 ©...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (2): 328–329.
Published: 20 March 2006
... protein synthesis ribosome–mRNA pair synthetic biology The ribosome is a 2.5 MDa molecular machine that converts the information encoded in mRNA into protein [ 1 ]. In bacterial cells, the ribosome is most commonly directed to mRNAs by sequences 5′ to the mRNA start codon known as a Shine...
