... -ethylmaleimide-sensitive fusion proteinattachment protein receptor) complexes between proteins on opposing lipid bilayers. Although regulation of SNARE complex assembly is not well understood, it is clear that two conserved protein families, the Sx (syntaxin) and the SM (Sec1p/Munc18) proteins, are central...

... © 2008 Biochemical Society 2008 docking exocytosis fusion pore insulin secretory granule live-cell imaging syntaxin Our current model of insulin granule exocytosis and recycling is shown in Figure 2 . Insulin-containing granules contain a plethora of other bioactive or structural...

... a similar C1 domain and binds to syntaxin to drive SV priming immediately preceding fusion [ 35 ]. Depletion of DAG in rbo ts mutants could potentially prevent SV priming and subsequent fusion, leading to the observed transmission defect ( Figure 2 ). This mechanism might be critical for the activity...