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Keywords: synaptic plasticity
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Articles
Biochem Soc Trans (2023) 51 (1): 315–330.
Published: 11 January 2023
...Elisa Corti; Carlos B. Duarte AMPA-type receptors for the neurotransmitter glutamate are very dynamic entities, and changes in their synaptic abundance underlie different forms of synaptic plasticity, including long-term synaptic potentiation (LTP), long-term depression (LTD) and homeostatic...
Articles
Biochem Soc Trans (2018) 46 (6): 1697–1705.
Published: 04 December 2018
... kinase stress synapses synaptic plasticity Waves of protein-based signaling networks become activated and inactivated during development in a tightly orchestrated and genetically controlled process that produces appropriately wired neural circuits [ 1 ]. As young vertebrates interact...
Articles
Biochem Soc Trans (2016) 44 (5): 1313–1319.
Published: 19 October 2016
... for organ transplant patients as well as to treat psoriasis and rheumatoid arthritis [ 53 – 55 ]. However, its role in synaptic plasticity, as well as in other processes such as insulin signaling [ 49 ], and cardiac function [ 56 – 58 ] make PP2B an attractive potential target for other conditions. In order...
Articles
Biochem Soc Trans (2015) 43 (3): 328–332.
Published: 01 June 2015
... protein synthesis synaptic plasticity tumour Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical calcium/calmodulin (Ca/CaM)-dependent protein kinase which phosphorylates and inactivates eEF2 [ 1 ]. eEF2 is required for the movement of ribosomes along mRNAs during translation elongation...
Articles
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... oxidative stress synaptic plasticity The majority of AD (Alzheimer's disease) and PD (Parkinson's disease) cases are ‘sporadic’, which means that there is no clear genetic pathway that causes the onset of the disease. This makes it more difficult to identify which factors trigger...
Articles
Biochem Soc Trans (2013) 41 (4): 815–820.
Published: 18 July 2013
... contribute towards neurodevelopmental disorders. In the present article, we review the current knowledge of the role of miRNAs in development and pathogenesis of the nervous system. Regulation of adult neurogenesis and synaptic plasticity has also been linked with various miRNAs [ 31 ]. The architecture...
Articles
Biochem Soc Trans (2013) 41 (1): 241–244.
Published: 29 January 2013
... and RNAs contained in exosomes secreted by emitting neurons could directly modify signal transduction and protein expression in receiving cells. Exosomes may be an ideal mechanism for anterograde and retrograde information transfer across synapses underlying local changes in synaptic plasticity. Exosomes...
Articles
Biochem Soc Trans (2010) 38 (6): 1527–1530.
Published: 24 November 2010
... is modified by the frequency with which the synapses are stimulated. This modulation of synaptic strength, or synaptic plasticity, probably forms the cellular basis for learning and memory. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting...
Articles
Biochem Soc Trans (2010) 38 (2): 493–497.
Published: 22 March 2010
..., molecular and behavioural analyses of experimental animal models of PD. In PD, a host of cellular and synaptic changes occur in the striatum in response to the massive loss of DA innervation. Chronic L -dopa therapy restores physiological synaptic plasticity and behaviour in treated PD animals, but most...
Articles
Biochem Soc Trans (2009) 37 (6): 1369–1374.
Published: 19 November 2009
... in neuronal differentiation, neuronal migration, synaptogenesis, structural remodelling, long-lasting forms of synaptic plasticity and higher cognitive functions. NMDAR-mediated Ca 2+ signalling in dendritic spines is not static, but can be remodelled in a cell- and synapse-specific manner by NMDAR subunit...
Articles
Biochem Soc Trans (2009) 37 (6): 1375–1377.
Published: 19 November 2009
...Donna M. McDade; Ann-Marie Conway; Allan B. James; Brian J. Morris The regulation of synaptic glutamate receptor and GABA A R (γ-aminobutyric acid subtype A receptor) levels is a key component of synaptic plasticity. Most forms of neuronal plasticity are associated with the induction...
Articles
Biochem Soc Trans (2009) 37 (6): 1323–1327.
Published: 19 November 2009
...-hippocampal NMDARs make important contributions to spatial memory performance. Hippocampal NMDAR-dependent synaptic plasticity has long been regarded as the key neural mechanism underlying spatial memory [ 3 , 16 ]. Despite this, there is still uncertainty and controversy regarding the precise role...
Articles
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
... the role of localized translational control in synaptic plasticity. It remains to be seen if the high-throughput methods can be applied quantitatively to study the dynamics of RNP (ribonucleoprotein) remodelling in specific neuronal populations during the neurodegenerative process. It is certain, however...
Articles
Biochem Soc Trans (2009) 37 (6): 1359–1363.
Published: 19 November 2009
...Mascia Amici; Andrew Doherty; Jihoon Jo; David Jane; Kwangwook Cho; Graham Collingridge; Sheila Dargan Calcium entry plays a major role in the induction of several forms of synaptic plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can...
Articles
Biochem Soc Trans (2009) 37 (6): 1364–1368.
Published: 19 November 2009
...), and evidence is accumulating that leptin modulates many neuronal functions. In particular, recent studies have indicated that leptin plays an important role in the regulation of hippocampal synaptic plasticity. Indeed leptin-insensitive rodents display impairments in hippocampal synaptic plasticity and defects...
Articles
Biochem Soc Trans (2006) 34 (5): 949–951.
Published: 25 October 2006
...J.R. Mellor Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA ( N -methyl- D -aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4...
Articles
Biochem Soc Trans (2006) 34 (5): 939–941.
Published: 25 October 2006
... 2006 active zone Bruchpilot calcium channel neuromuscular junction synaptic plasticity vesicle fusion Synapses are specialized intercellular contact sites, required for the rapid transmission of signals between neurons and their target cells. Chemical synaptic communication is mediated...
Articles
Biochem Soc Trans (2006) 34 (4): 600–604.
Published: 21 July 2006
... B) to glutamate synapses makes this system attractive as a dynamic, activity-dependent regulator of excitatory transmission and synaptic plasticity in the adult brain. Development of stable LTP (long-term potentiation) in response to high-frequency stimulation requires new gene expression...
Articles
Biochem Soc Trans (2006) 34 (1): 59–63.
Published: 20 January 2006
... in embryonic stem cells. The first example of a gene that hitherto had no known role in synapse biology was that encoding the tyrosine kinase Fyn [ 17 ]. Null mutation in the fyn gene resulted in mice with a learning deficit and impaired synaptic plasticity. Since then, close to 200 different genes have been...
Articles
Biochem Soc Trans (2005) 33 (5): 1029–1032.
Published: 26 October 2005
... display abnormal brain development and leptin actively participates in the development of the hypothalamus. In the hippocampus, leptin is a potential cognitive enhancer as genetically obese rodents with dysfunctional leptin receptors display impairments in hippocampal synaptic plasticity. Moreover, direct...
Articles
Biochem Soc Trans (2005) 33 (6): 1354–1356.
Published: 26 October 2005
... © 2005 The Biochemical Society 2005 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) calcium/calmodulin-dependent protein kinase (CaMKII) long-term potentiation (LTP) phosphorylation protein kinase A (PKA) synaptic plasticity AMPA α-amino-3-hydroxy...
Articles
Biochem Soc Trans (2005) 33 (6): 1345–1349.
Published: 26 October 2005
... and serine). Mouse KOs (knockouts) revealed that, in different types of synapses, RIM1α is essential for different forms of synaptic plasticity. In CA1-region Schaffer-collateral excitatory synapses and in GABAergic synapses (where GABA is γ-aminobutyric acid), RIM1α is required for maintaining normal...