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Keywords: synapse
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Articles
Biochem Soc Trans (2013) 41 (1): 72–78.
Published: 29 January 2013
... at central synapses. Neurons expend huge amounts of energy to dynamically traffic AMPARs, which are constantly inserted, internalized and recycled, even at synapses that maintain a consistent stable synaptic strength [ 2 ]. Changing the balance of AMPAR trafficking into and out of synapses is a major way...
Articles
Biochem Soc Trans (2010) 38 (2): 511–515.
Published: 22 March 2010
...Alexandros Poulopoulos Synapses between nerve cells in the mammalian brain are not only extremely numerous but also very diverse with respect to their structural and functional characteristics. This heterogeneity arises despite the fact that a set of common basic protein ‘building blocks’ is shared...
Articles
Biochem Soc Trans (2010) 38 (2): 471–475.
Published: 22 March 2010
... cognitive functions. This pathology is defined by abnormally shaped synapses in which the postsynaptic membrane modifies its curvature and potentially engulfs the juxtaposed presynaptic membrane. Using the intrahippocampally injected ME7 prion model, we further detailed the structural alterations...
Articles
Biochem Soc Trans (2010) 38 (2): 564–570.
Published: 22 March 2010
...Catherine M. Cowan; Francis Chee; David Shepherd; Amritpal Mudher Axonal microtubules are essential for transport of materials to the synapse. Compromised microtubules and synaptic loss have been demonstrated in AD (Alzheimer's disease), which is believed to contribute to cognitive dysfunction...
Articles
Biochem Soc Trans (2006) 34 (5): 877–881.
Published: 25 October 2006
...F.A. Stephenson The fidelity of synaptic function is dependent on the expression of the appropriate neurotransmitter receptor subtype, the targeting and trafficking of receptors to synapses as well as the regulation of the actual number of receptors at synapses. GABA A (γ-aminobutyric acid type...
Articles
Biochem Soc Trans (2006) 34 (5): 931–935.
Published: 25 October 2006
.... α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) allosteric protein calcium sensor protein that interacts with protein C-kinase 1 (PICK1) synapse Learning and memory involve long-term changes at central nervous system synapses. AMPARs [AMPA (α-amino-3-hydroxy-5...
Articles
Biochem Soc Trans (2006) 34 (1): 64–67.
Published: 20 January 2006
... properly. Understanding the molecular architecture of functional glutamatergic synapses is therefore an important challenge in neurobiology. To address this question, we combine the techniques of genetics, molecular biology and electrophysiology in the nematode Caenorhabditis elegans . To date, genetic...
Articles
Biochem Soc Trans (2006) 34 (1): 43–44.
Published: 20 January 2006
... and behavioural levels. 1 To whom correspondence should be addressed (email V.M.O'Connor@soton.ac.uk ). 31 10 2005 © 2006 The Biochemical Society 2006 genetic disease model organism molecular determinant protein misfolding synapse synaptic function The Biochemical Society...
Articles
Biochem Soc Trans (2006) 34 (1): 59–63.
Published: 20 January 2006
...S.G.N. Grant Synapse proteomics has recently resulted in a quantum leap in knowledge of the protein composition of brain synapses and its phosphorylation. We now have the first draft picture of the synapse, comprising ∼1000 proteins. This is not matched by available methods of functional analysis...
Articles
Biochem Soc Trans (2005) 33 (6): 1295–1298.
Published: 26 October 2005
...P.C. Salinas The formation of functional synapses requires a proper dialogue between incoming axons and their future synaptic targets. As axons approach their target, they are instructed to slow down and remodel to form proper presynaptic terminals. Although significant progress has been made...
Articles
Biochem Soc Trans (2003) 31 (4): 885–888.
Published: 01 August 2003
...R.J. Wenthold; N. Sans; S. Standley; K. Prybylowski; R.S. Petralia The N -methyl-d-aspartate (NMDA) receptor plays a central role at excitatory synapses where it has been implicated in multiple functions associated with synaptic plasticity. While this receptor has been intensely studied...
Articles
Biochem Soc Trans (2003) 31 (4): 889–892.
Published: 01 August 2003
...J.-M. Fritschy; C. Schweizer; I. Brünig; B. Lüscher Postsynaptic clustering of GABA A (type A γ-aminobutyric acid) receptors is essential to ensure proper function of GABAergic synapses. This process is initiated during synapse formation and is maintained throughout life. The tubulin-associated...