... in brain function and their therapeutic importance, enormous research efforts have been devoted to elucidating the structure and function of these receptors and developing novel therapeutics. Recent studies have resolved the structures of NMDARs in multiple functional states, and have revealed the detailed...

... disorders. These findings not only underscore the importance of the BAF chromatin remodelers in cellular physiological processes, but urge a more detailed understanding of their structure and molecular action to enable the development of targeted therapeutic approaches for diseases with BAF complex...

... be carefully considered. Understanding of drug target mechanism can dramatically accelerate early-stage target-based development of novel antimalarials and allows for structural modifications even during late-stage preclinical development. Here, we have provided an overview of three promising antimalarial...

.... However, the structures of the mitochondrial ADP/ATP carrier, a member of the family, clearly demonstrated that its structural fold is monomeric, lacking a conserved dimerisation interface. A re-evaluation of previously published data, with the advantage of hindsight, concluded that technical errors were...

...Ido Caspy; Nathan Nelson Plant photosystem I (PSI) is one of the most intricate membrane complexes in nature. It comprises two complexes, a reaction center and light-harvesting complex (LHC), which together form the PSI–LHC supercomplex. The crystal structure of plant PSI was solved with two...

... to solve the three-dimensional structure of the protein. We review here our recent successful approach to build the first structural model of dimeric LRRK2 by an integrative modeling approach. cross-linking leucine-rich repeat kinase modeling structure Parkinson's disease (PD) is a slow...

...Manuel Palacín; Ekaitz Errasti-Murugarren; Albert Rosell Heteromeric amino acid transporters (HATs) are relevant targets for structural studies. On the one hand, HATs are involved in inherited and acquired human pathologies. On the other hand, these molecules are the only known examples of solute...

... inositol phosphate cell-signalling drug pharmacology structure The inositol pyrophosphates (PP-IPs; Figure 1 ) comprise a unique class of cell-signalling molecules characterized by their functionally-significant and highly ‘energetic’ diphosphate groups [ 1 , 2 ]. As many as seven (‘InsP 7...

... by additional structural elements or severe aggregations problems. 1 Present address: Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland . 2 To whom correspondence should be addressed (email...

...Mariusz Jaremko; Łukasz Jaremko; Garima Jaipuria; Stefan Becker; Markus Zweckstetter The 3D structure of the 18-kDa transmembrane (TM) protein TSPO (translocator protein)/PBR (peripheral benzodiazepine receptor), which contains a binding site for benzodiazepines, is important to better understand...

... regulatory sites for JAK2 activity. The crystal structure of the JAK2 JH2 domain provides an explanation for the functional findings and shows that JH2 adopts a prototypical kinase fold, but binds MgATP through a non-canonical mode. The structure of the most prevalent pathogenic JH2 mutation V617F shows...

...Tony Warne; Christopher G. Tate Structures of the inactive state of the thermostabilized β 1 -adrenoceptor have been determined bound to eight different ligands, including full agonists, partial agonists, inverse agonists and biased agonists. Comparison of the structures shows distinct differences...

... is a complex assembly of five RNAs (U1, U2, U4, U5 and U6) and many dozens of associated proteins. Although a high-resolution structure of the spliceosome is not yet available, inroads have been made towards understanding its structure and function. There is growing evidence suggesting that U2 and U6 RNAs...

...N. Beglova; H. Jeon; C. Fisher; S.C. Blacklow The LDLR (low-density lipoprotein receptor) is a modular protein built from several distinct structural units: LA (LDLR type-A), epidermal growth factor-like and β-propeller modules. The low pH X-ray structure of the LDLR revealed long-range...

... Meeting held at Chancellors Conference Centre, University of Manchester, 1–3 December 2003 12 December 2003 © 2004 Biochemical Society 2004 activation conformation integrin ligand priming structure Abbreviations used: EGF, epidermal growth factor; LABS, ligand...

...P.J. Baker The determination and comparison of the structures of a number of glutamate dehydrogenases that span the spectrum of thermal stability from mesophiles to hyperthermophiles have revealed that the formation of extended ion-pair networks is a major stabilizing feature in the adaptation...

... customized to chelate the critical zinc ion at the enzymes' active site. These initial efforts were supported by X-ray and NMR data on MMP complexes, exploiting sequence and structural differences in the principal specificity pocket of the enzymes, leading to subtype-selective MMP inhibitors. This review...

...G. Schäfer; S. Kardinahl Iron and manganese superoxide dismutases are phylogenetically closely related. They are compared by in silico analysis with regard to their metal specificity and their three-dimensional structure. Special attention is given to the structure and properties of superoxide...

... of Nottingham, 19–20 June 2003 23 July 2003 © 2003 Biochemical Society 2003 aqueous solutions hydrodynamics membrane spectroscopy structure Interm olecular A ssociations in 2D and 3D Biochem icalSociety Focused M eeting Intermolecular Associations in 2D and 3D Focused Meeting held...

... and aggregation. Detailed understanding of these phenomena is therefore crucial in order to rationalize different phases of the diseases. In the past decade, a few studies have focused on the structural properties of polyglutamine and on the molecular bases of the aggregation process. Most of these studies have...

...M. Gajhede Plant peroxidases are capable of binding phenolic substrates, and it has been possible to crystallize complexes between horseradish peroxidase C (HRP C) and benzhydroxamic acid. The X-ray structures of the binary HRP C: ferulic acid complex and the ternary HRP C: CN − :ferulic acid...

...M. W. Hayman; T. Fawcett; T. F. Schierer; J. W. Simon; J. T. M. Kroon; J. S. Gilroy; D. W. Rice; J. Rafferty; A. P. Turnbull; S. E. Sedelnikova; A. R. Slabas In an attempt to rationalize the relationship between structure and substrate selectivity of glycerol-3-phosphate acyltransferase (GPAT, 1AT...