...Mark J. Fogg; Anthony J. Wilkinson In recent times, there has been a large increase in the number of protein structures deposited in the Protein Data Bank. Structural genomics initiatives have contributed to this expansion through their focus on high-throughput structural determination. This has...

... sequencing. These so-called ‘carbohydrate-active enzymes’ lend themselves to classification by sensitive sequence similarity detection methods. The modularity, often extremely complex, of these enzymes must first be dissected and annotated before high throughput characterization or ‘structural genomics...