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Keywords: structural biology
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Articles
Biochem Soc Trans (2023) BST20220342.
Published: 18 January 2023
...(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . intrinsically disordered proteins molecular scaffolds structural biology transcription...
Articles
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages, infect prokaryotes and are the most abundant biological entity on the planet [ 1...
Articles
Biochem Soc Trans (2022) 50 (1): 375–386.
Published: 25 January 2022
... ( walter.j.chazin@vanderbilt.edu ) 4 11 2021 20 12 2021 22 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 DNA synthesis and repair nucleotide excision repair structural biology Nucleotide excision repair (NER...
Articles
Biochem Soc Trans (2021) 49 (6): 2917–2927.
Published: 25 November 2021
... on behalf of the Biochemical Society 2021 ABC transporter EPR spectroscopy NMR spectroscopy structural biology The superfamily of ABC transporters contains a variety of proteins from all domains of life that fulfil a multitude of functions in cellular processes. Defects in ABC transporters...
Articles
Biochem Soc Trans (2021) 49 (5): 1985–1995.
Published: 13 September 2021
... Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. immunology structural biology T-cells The human adaptive immune system has conserved a tripartite lymphocyte compartment comprising B cells, αβ and γδ T cells for over...
Articles
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 membranes small gtpases small molecules structural biology trafficking Cytoplasmic small GTPases and most of their interacting proteins belong to the broad class of peripheral membrane proteins, which...
Articles
Biochem Soc Trans (2020) 48 (6): 2625–2641.
Published: 01 December 2020
... numerous vaccination and clinical trials have emerged alongside an innumerable number of drug discovery studies currently in development for disease intervention. Informing every step of the viral replication cycle has been an unprecedented ‘call-to-arms' by the global structural biology community...
Articles
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
...Tristan O. C. Kwan; Danny Axford; Isabel Moraes The aim of structural biology has been always the study of biological macromolecules structures and their mechanistic behaviour at molecular level. To achieve its goal, multiple biophysical methods and approaches have become part of the structural...
Articles
Biochem Soc Trans (2020) 48 (5): 2089–2100.
Published: 02 October 2020
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chromosomes condensin DNA binding single-molecule SMC structural biology AFM atomic force microscopy EM electron microscopy HAWK HEAT proteins associated...
Articles
Biochem Soc Trans (2020) 48 (2): 621–629.
Published: 20 April 2020
... for interpreting our own functional data, we need to remind ourselves that they stand on the shoulders of a large body of previous structural studies, many of which are still appropriate for use in understanding our results. In this mini-review, we discuss the history of respiratory chain structural biology...
Articles
Biochem Soc Trans (2020) 48 (2): 507–516.
Published: 20 March 2020
... anti-CRISPR proteins molecular interactions molecular mechanisms structural biology In the battle for survival, bacteria and archaea have evolved mechanistically diverse defense mechanisms to resist their predators [ 1 ]. The prokaryotic CRISPR–Cas immune system uniquely provides a memory...
Articles
Biochem Soc Trans (2019) 47 (6): 1773–1780.
Published: 05 December 2019
... on behalf of the Biochemical Society 2019 expanded genetic code oligomerization protein complexes protein engineering structural biology synthetic biology The fundamental basis behind protein oligomerisation is the network of intricate interactions holding the individual units together...
Articles
Biochem Soc Trans (2019) 47 (5): 1259–1268.
Published: 18 October 2019
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ATP-binding cassette transporters cardiovascular disease cholesterol transport lipid metabolism sitosterolemia structural biology ABCG5 and ABCG8 genes are situated head-to-head...
Articles
Biochem Soc Trans (2019) 47 (1): 399–410.
Published: 07 February 2019
... the Creative Commons Attribution License 4.0 (CC BY) . Cryo-EM Mediator complex structural biology transcription The Mediator complex was initially identified in yeast in the early 1990s independently by the Kornberg and the Young laboratories. The Kornberg laboratory isolated Mediator...
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Biochem Soc Trans (2019) 47 (1): 281–293.
Published: 15 January 2019
...Tom Ceska; Chun-Wa Chung; Rob Cooke; Chris Phillips; Pamela A. Williams The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including...
Articles
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
...@canterbury.ac.nz ) or Cherine Bechara ( cherine.bechara@igf.cnrs.fr ) 13 9 2018 27 11 2018 4 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 mass spectrometry membrane proteins proteomics structural biology Mass...
Articles
Biochem Soc Trans (2018) 46 (6): 1753–1770.
Published: 13 December 2018
... is required. Here, we review some of the key research findings from the last couple of decades and summarise the strategies being explored for therapeutic intervention. drug discovery and design fibroblast growth factor receptors receptor tyrosine kinases structural biology Through their role...
Articles
Biochem Soc Trans (2018) 46 (6): 1475–1484.
Published: 04 December 2018
... exercise caution when incorporating a newly solved structure into a new mechanistic model if the conformation is an inward one. Finally, it is clear from the direction of the field of structural biology as a whole that the membrane and local lipid environment should be considered when investigating...
Articles
Biochem Soc Trans (2018) 46 (6): 1495–1504.
Published: 21 November 2018
... opportunities for exploiting SMALPs to expand our understanding of structural and functional properties of MPs. membrane proteins protein purification structural biology structural characterisation Proteins embedded within lipid-based membranes mediate the interactions between cells...
Articles
Biochem Soc Trans (2018) 46 (6): 1541–1549.
Published: 31 October 2018
... is depicted as spheres and coloured green for carbon, red for oxygen, and blue for nitrogen. ( B ) Packing of OX 2 R–PGS in the crystal lattice. Note that many of the crystal contacts occur through the PGS domain [ 58 ]. Figure prepared using PyMOL [ 62 ]. protein engineering structural biology...
Articles
Biochem Soc Trans (2018) 46 (5): 1367–1379.
Published: 21 September 2018
... discovery and design structural biology Computational methods of drug discovery have a basis in the very earliest structural studies of protein molecules. The first structure of a protein, that of sperm whale myoglobin initially at 6 Å resolution [ 1 ] then refined to 2 Å resolution [ 2 ], revealed...
Articles
Biochem Soc Trans (2018) 46 (2): 379–389.
Published: 14 March 2018
... proteins. 3 12 2017 26 1 2018 30 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 biophysics lipid-binding domains lipids membranes microfilaments structural biology Lipid membranes determine...
Articles
Biochem Soc Trans (2016) 44 (3): 838–844.
Published: 09 June 2016
... the native lipid bilayer of a membrane protein during purification and biophysical analysis. Overcoming bottlenecks in the membrane protein structural biology pipeline, primarily by maintaining protein stability, will facilitate the elucidation of many more membrane protein structures in the near future...
Articles
Biochem Soc Trans (2016) 44 (1): 79–87.
Published: 09 February 2016
... of activated α-mannosides, but is unprecedented ‘on-enzyme’; it will be interesting to see how this area evolves. biofuels conformational analysis drug design glycobiology glycosidase structural biology Through pioneering studies by the groups of Sinnott and Withers, there is compelling...
Articles
Biochem Soc Trans (2016) 44 (1): 61–67.
Published: 09 February 2016
... the glycosylation. These studies not only broaden our knowledge of the modes-of-action of this family of enzymes but also open up potential avenues for the rational design of effective and selective inhibitors of O -glycosylation. GalNAc-Ts retention mechanism structural biology lectin domain flexible linker...
Articles
Biochem Soc Trans (2014) 42 (1): 52–58.
Published: 23 January 2014
... GTPase NMR Ral Ral-binding protein 1 (RalBP1) Ral-interacting protein of 76 kDa (RLIP76) structural biology Small GTPases of the Ras superfamily are characterized by their ability to switch between the GDP-bound ‘off’ state and the GTP-bound active state in response to upstream signals...
Articles
Biochem Soc Trans (2013) 41 (5): 1317–1324.
Published: 23 September 2013
... structural biology Hydrogen is one of the energy carriers of the future. The investigation of hydrogen metabolism from bacteria and archaea has a strong impact on possible scenarios for future energy supply [ 1 ]. Hydrogenases are enzymes which catalyse the reversible oxidation of molecular hydrogen...
Articles
Biochem Soc Trans (2013) 41 (4): 975–980.
Published: 18 July 2013
... correspondence should be addressed (email Isabelle.lucet@monash.edu ). 3 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 catalytic activity fluorescence-based assay kinase-affinity chromatography nucleotide binding pseudokinase structural biology...
Articles
Biochem Soc Trans (2013) 41 (4): 1037–1041.
Published: 18 July 2013
... of chemical inhibitors. 1 To whom correspondence should be addressed (email richard.bayliss@le.ac.uk ). 26 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 activation mechanism Aurora-A drug discovery Nek7 protein kinase structural biology...
Articles
Biochem Soc Trans (2013) 41 (1): 17–28.
Published: 29 January 2013
... structural biology substrate secretion Type IV secretion Bacteria have evolved several specialized machineries that span the cellular envelope to bring about transport across the membrane permeability barrier. Gram-negative bacteria have evolved seven different types of secretion systems from...
Articles
Biochem Soc Trans (2011) 39 (5): 1311–1312.
Published: 21 September 2011
... of structural biology of proteins, presentations covering both historical and current research were given by a number of leading biochemists from both countries. Papers based on these talks have been prepared for this issue of Biochemical Society Transactions . 1 Correspondence may be addressed to either...
Articles
Biochem Soc Trans (2010) 38 (4): 928–933.
Published: 26 July 2010
... r.lewis@ncl.ac.uk ). 18 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 Bacillus subtilis kinase signal transduction stressosome stress response structural biology The established model of Gram-positive micro-organisms is the soil-dwelling rod...
Articles
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... 7 (Acot7) platelet glycoprotein Ibα protein–protein interaction structural biology thrombin X-ray crystallography MX (macromolecular X-ray crystallography) is the most popular method to obtain high-resolution structural information on protein–protein complexes, and it yields the most...
Articles
Biochem Soc Trans (2008) 36 (4): 723–731.
Published: 22 July 2008
... topological arrangements of subunits and interactions within RNA–protein complexes studied in our laboratory over the last 5 years. These studies exemplify the emerging role and potential of MS as a complementary structural biology methodology and demonstrate its unique niche in investigations of dynamic...
Articles
Biochem Soc Trans (2006) 34 (5): 887–893.
Published: 25 October 2006
...-dependent inactivation (CDI) calmodulin (CaM) IQ domain structural biology voltage-gated calcium channel (Ca V ) Voltage-gated calcium channels (Ca V s) play a unique role in the interplay between electrical and chemical signalling in biological systems [ 1 , 2 ]. Ca V s respond to membrane...