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Keywords: structural biology
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Articles
Biochem Soc Trans (2023) 51 (6): 2143–2152.
Published: 20 December 2023
... 2023 11 12 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 iron metabolism membrane proteins structural biology transport Iron was in evolutionary terms early incorporated into biological systems and now plays...
Articles
Biochem Soc Trans (2023) 51 (3): 1225–1233.
Published: 04 May 2023
... inhibition structural biology During mitosis, replicated chromosomes are aligned on the mitotic spindle and segregated equally to the daughter cells. To ensure correct segregation, sister chromatid pairs are linked during S phase [ 1 , 2 ] by the ring-shaped protein complex cohesin [ 3 , 4 ], which...
Articles
Biochem Soc Trans (2023) 51 (1): 125–135.
Published: 18 January 2023
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . intrinsically disordered proteins molecular scaffolds structural biology transcription The emergence of diverse functional roles for intrinsically disordered regions (IDRs) has highlighted...
Articles
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages, infect prokaryotes and are the most abundant biological entity on the planet [ 1...
Articles
Biochem Soc Trans (2022) 50 (1): 375–386.
Published: 25 January 2022
... ( walter.j.chazin@vanderbilt.edu ) 4 11 2021 20 12 2021 22 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 DNA synthesis and repair nucleotide excision repair structural biology The XPF-ERCC1 complex is likely...
Articles
Biochem Soc Trans (2021) 49 (6): 2917–2927.
Published: 25 November 2021
... spectroscopy NMR spectroscopy structural biology The NBDs of ABC transporters are highly conserved domains, which display a similar set of motifs, necessary for ATP binding and hydrolysis. MsbA displays all seven motifs (Walker A/B, Signature Motif, A/D/Q-loop, His-Switch) in its two NBDs, which can...
Articles
Biochem Soc Trans (2021) 49 (5): 1985–1995.
Published: 13 September 2021
... Society under a transformative agreement with CAUL. immunology structural biology T-cells The human adaptive immune system has conserved a tripartite lymphocyte compartment comprising B cells, αβ and γδ T cells for over 450 million years of vertebrate evolution [ 1 ]. Whilst great strides...
Articles
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 membranes small gtpases small molecules structural biology trafficking Cytoplasmic small GTPases and most of their interacting proteins belong to the broad class of peripheral membrane proteins, which...
Articles
Biochem Soc Trans (2020) 48 (6): 2625–2641.
Published: 01 December 2020
... numerous vaccination and clinical trials have emerged alongside an innumerable number of drug discovery studies currently in development for disease intervention. Informing every step of the viral replication cycle has been an unprecedented ‘call-to-arms' by the global structural biology community...
Articles
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
...Tristan O. C. Kwan; Danny Axford; Isabel Moraes The aim of structural biology has been always the study of biological macromolecules structures and their mechanistic behaviour at molecular level. To achieve its goal, multiple biophysical methods and approaches have become part of the structural...
Articles
Biochem Soc Trans (2020) 48 (5): 2089–2100.
Published: 02 October 2020
... under the Creative Commons Attribution License 4.0 (CC BY) . chromosomes condensin DNA binding single-molecule SMC structural biology Organising DNA throughout the cell cycle to ensure correct gene expression, DNA replication, and chromosome division is a remarkable feat. Two...
Articles
Biochem Soc Trans (2020) 48 (2): 621–629.
Published: 20 April 2020
... for interpreting our own functional data, we need to remind ourselves that they stand on the shoulders of a large body of previous structural studies, many of which are still appropriate for use in understanding our results. In this mini-review, we discuss the history of respiratory chain structural biology...
Articles
Biochem Soc Trans (2020) 48 (2): 507–516.
Published: 20 March 2020
... anti-CRISPR proteins molecular interactions molecular mechanisms structural biology In the battle for survival, bacteria and archaea have evolved mechanistically diverse defense mechanisms to resist their predators [ 1 ]. The prokaryotic CRISPR–Cas immune system uniquely provides a memory...
Articles
Biochem Soc Trans (2019) 47 (6): 1773–1780.
Published: 05 December 2019
... 2019 15 11 2019 18 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 expanded genetic code oligomerization protein complexes protein engineering structural biology synthetic biology The vast expanse of protein...
Articles
Biochem Soc Trans (2019) 47 (5): 1259–1268.
Published: 18 October 2019
... a mechanistic view of ABCG5/G8-mediated sterol transport. Correspondence: Jyh-Yeuan Lee ( jyh-yeuan.lee@uottawa.ca ) 18 7 2019 26 9 2019 30 9 2019 ATP-binding cassette transporters cardiovascular disease cholesterol transport lipid metabolism sitosterolemia structural biology...
Articles
Biochem Soc Trans (2019) 47 (1): 399–410.
Published: 07 February 2019
... Mediator complex structural biology transcription The Mediator Head module is composed of seven highly conserved subunits (Med6, Med8, Med11, Med17, Med18, Med20 and Med22) and together with the Middle module, it plays an essential role during the PIC assembly, contacting the RNA Pol II...
Includes: Supplementary data
Articles
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
... these methods generate fragment ions correlating to the exposed surface of the studied native proteins [ 48 ]. mass spectrometry membrane proteins proteomics structural biology Mass spectrometry (MS) has evolved in recent years to become a pillar for integrative structural biology approaches...
Articles
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Biochem Soc Trans (2019) 47 (1): 281–293.
Published: 15 January 2019
...Tom Ceska; Chun-Wa Chung; Rob Cooke; Chris Phillips; Pamela A. Williams The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including...
Articles
Biochem Soc Trans (2018) 46 (6): 1753–1770.
Published: 13 December 2018
... structural biology Through their role in signal transduction pathways, protein kinases mediate a plethora of cellular phenotypic changes such as cell growth, proliferation, differentiation and survival [ 1 ]. Receptor tyrosine kinases (RTKs) are an important kinase subfamily whose members span...
Articles
Biochem Soc Trans (2018) 46 (6): 1475–1484.
Published: 04 December 2018
... , D. , Bill , R.M. , Jawhari , A. and Rothnie , A.J. ( 2016 ) Overcoming bottlenecks in the membrane protein structural biology pipeline . Biochem. Soc. Trans. 44 , 838 – 844 10.1042/BST20160049 48 Marsh , D. ( 2008 ) Protein modulation of lipids, and vice-versa...
Articles
Biochem Soc Trans (2018) 46 (6): 1495–1504.
Published: 21 November 2018
...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . membrane proteins protein purification structural biology structural characterisation...
Articles
Biochem Soc Trans (2018) 46 (6): 1541–1549.
Published: 31 October 2018
... structural biology transmembrane proteins Proteins tend to be classified into one of two broad categories, globular cytoplasmic proteins and integral membrane proteins (IMPs) [ 1 ]. This simple classification is defined by a proteins intrinsic ability to produce a stable, functional structure...
Articles
Biochem Soc Trans (2018) 46 (5): 1367–1379.
Published: 21 September 2018
... be found in the reviews cited above. computational biochemistry drug discovery and design structural biology Computational methods of drug discovery have a basis in the very earliest structural studies of protein molecules. The first structure of a protein, that of sperm whale myoglobin...
Articles
Biochem Soc Trans (2018) 46 (2): 379–389.
Published: 14 March 2018
... and non-molecular factors. biophysics lipid-binding domains lipids membranes microfilaments structural biology Lipid membranes determine the shape of the cell surface and organelles. The lipid membrane is a bilayer consisting of phospholipids, sphingolipids, and cholesterol in various...
Articles
Biochem Soc Trans (2016) 44 (3): 838–844.
Published: 09 June 2016
... the native lipid bilayer of a membrane protein during purification and biophysical analysis. Overcoming bottlenecks in the membrane protein structural biology pipeline, primarily by maintaining protein stability, will facilitate the elucidation of many more membrane protein structures in the near future...
Articles
Biochem Soc Trans (2016) 44 (1): 61–67.
Published: 09 February 2016
... and consequently provides an explanation as to why Thr moieties in peptide acceptors are glycosylated more efficiently by this enzyme than their Ser counterparts ( Figure 2 a). GalNAc-Ts retention mechanism structural biology lectin domain flexible linker enzyme dynamics Glycosyltransferases (GTs...
Articles
Biochem Soc Trans (2016) 44 (1): 79–87.
Published: 09 February 2016
... © 2016 Authors; published by Portland Press Limited 2016 biofuels conformational analysis drug design glycobiology glycosidase structural biology Glycans are found almost everywhere, and the enzymes that synthesize, modify and degrade these complex molecules are central to human...
Articles
Biochem Soc Trans (2014) 42 (1): 52–58.
Published: 23 January 2014
... GTPase NMR Ral Ral-binding protein 1 (RalBP1) Ral-interacting protein of 76 kDa (RLIP76) structural biology Small GTPases of the Ras superfamily are characterized by their ability to switch between the GDP-bound ‘off’ state and the GTP-bound active state in response to upstream signals...
Articles
Biochem Soc Trans (2013) 41 (5): 1317–1324.
Published: 23 September 2013
... structural biology Hydrogen is one of the energy carriers of the future. The investigation of hydrogen metabolism from bacteria and archaea has a strong impact on possible scenarios for future energy supply [ 1 ]. Hydrogenases are enzymes which catalyse the reversible oxidation of molecular hydrogen...
Articles
Biochem Soc Trans (2013) 41 (4): 975–980.
Published: 18 July 2013
... fluorescence-based assay kinase-affinity chromatography nucleotide binding pseudokinase structural biology The breadth and functional diversity of the pseudokinase family have only started to emerge. Although pseudokinases display a typical kinase fold, constructed of the ten canonical subdomains...
Articles
Biochem Soc Trans (2013) 41 (4): 1037–1041.
Published: 18 July 2013
...-A drug discovery Nek7 protein kinase structural biology The eukaryotic cell cycle is tightly regulated by protein phosphorylation, which peaks during mitosis and is associated with drastic reorganization of cellular structures and protein activities [ 1 ]. These mitotic phosphorylation events...
Articles
Biochem Soc Trans (2013) 41 (1): 17–28.
Published: 29 January 2013
... structural biology substrate secretion Type IV secretion Bacteria have evolved several specialized machineries that span the cellular envelope to bring about transport across the membrane permeability barrier. Gram-negative bacteria have evolved seven different types of secretion systems from...
Articles
Biochem Soc Trans (2011) 39 (5): 1311–1312.
Published: 21 September 2011
... of structural biology of proteins, presentations covering both historical and current research were given by a number of leading biochemists from both countries. Papers based on these talks have been prepared for this issue of Biochemical Society Transactions . 1 Correspondence may be addressed to either...
Articles
Biochem Soc Trans (2010) 38 (4): 928–933.
Published: 26 July 2010
..., and the obvious conclusion is that it is provided by the stressosome. © The Authors Journal compilation © 2010 Biochemical Society 2010 Bacillus subtilis kinase signal transduction stressosome stress response structural biology The established model of Gram-positive micro-organisms...
Articles
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... structures solved by different groups, before concluding in the ‘Outlook’ section. © The Authors Journal compilation © 2008 Biochemical Society 2008 acyl-CoA thioesterase 7 (Acot7) platelet glycoprotein Ibα protein–protein interaction structural biology thrombin X-ray crystallography...
Articles
Biochem Soc Trans (2008) 36 (4): 723–731.
Published: 22 July 2008
... topological arrangements of subunits and interactions within RNA–protein complexes studied in our laboratory over the last 5 years. These studies exemplify the emerging role and potential of MS as a complementary structural biology methodology and demonstrate its unique niche in investigations of dynamic...
Articles
Biochem Soc Trans (2006) 34 (5): 887–893.
Published: 25 October 2006
...-dependent inactivation (CDI) calmodulin (CaM) IQ domain structural biology voltage-gated calcium channel (Ca V ) Voltage-gated calcium channels (Ca V s) play a unique role in the interplay between electrical and chemical signalling in biological systems [ 1 , 2 ]. Ca V s respond to membrane...