... the antigen originated, i.e. the tumor bed. The tumor stroma holds a prime role in this process by hosting specialized APC niches, apparently distinct from tertiary lymphoid structures, that support second antigenic touch encounters and CD8+ T cell effector proliferation and differentiation. We propose...

...Begum Erdogan; Donna J. Webb Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of carcinomas that emerge in the tumor microenvironment as a result of signals derived from the cancer cells. Biochemical cross-talk between cancer cells and CAFs as well as mechanical...

... evolution plastid division stroma Plastids have a prokaryotic history and the prevailing endosymbiotic theory holds that plastids arose approximately one billion years ago through symbiosis of a eukaryotic host cell and a free-living photosynthetic prokaryotic organism, closely related...

...-environment can influence epithelial cell behaviour across a number of disease sites, and Barrett's oesophagus is another example. More research is required to understand the key cell components in the stroma which influence cancer development. Ultimately, such knowledge should enable optimal strategies...