...), but the mechanisms of the selectivity are not as well understood. We have discovered that Rhes, a protein enriched in the striatum, removes mitochondria via the mitophagy process. The process becomes intensified in the presence of 3-NP, thereby eliminating most of the mitochondria from the striatum. We put forward...

... animal behavior leucine-rich repeat kinase neurotransmission Parkinson's disease striatum Parkinson's disease (PD) has long been considered a sporadic disorder in which genetics played hardly any role. This view was changed by the discovery of familial forms linked to precise gene alterations...

... plasticity in the brain. In the nucleus striatum, LTD and LTP represent key cellular substrates for adaptive motor control and procedural memory. It has been suggested that their impairment could account for the onset and progression of motor symptoms of PD (Parkinson's disease), a neurodegenerative disorder...

... anhedonia depression dopamine mood reward striatum ACC anterior cingulate gyrus DA dopamine DAT DA transporter fMRI functional magnetic resonance imaging ICSS intracranial self-stimulation MDD major depressive disorder Nacc nucleus accumbens OFC...

...C. Fiorentini; C. Missale In the striatum, dopamine D 1 R (D 1 receptor) activation potentiates NMDA ( N -methyl- D -aspartate) transmission and is required for NMDA-mediated long-term potentiation at corticostriatal synapses. By using a combination of co-immunoprecipitation, pull-out...