... in translation regulation beyond initiation have only begun to be elucidated. Methodological advances enabled critical discoveries on the control of translation elongation, highlighting its important role in translation repression and the synthesis of stress-response proteins. In this article, we discuss recent...

... ) 31 1 2023 27 3 2023 28 3 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 amyotrophic lateral sclerosis antisense oligo mitochondrial dysfunction Parkinson's disease stress response Mitochondria produce energy...

... 2 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 gametogenesis HSF1 insulin/IGF-1 signaling proteostasis stress response Proteostasis refers to the cellular state in which proteins are properly synthesized, folded...

... was the discovery of a protein homeostasis mechanism driven by unassembled ribosomal proteins, referred to as the Ribosome Assembly Stress Response (RASTR), that controls RPG transcription through the reversible condensation of Ifh1. Correspondence: David Shore ( David.Shore@unige.ch ) or Benjamin Albert...

... under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Correspondence: Theo Rein ( theorein@psych.mpg.de ) FKBP51 post-translational modification signal transduction stress response The physiological stress response is elicited whenever a change in the environment...

... [ 42 ]. Interestingly, ARTC1—besides its localisation at the plasma membrane—is also present at the endoplasmic reticulum (ER), with its catalytic domain facing the ER lumen; here, ARTC1 can ADP-ribosylate GRP78/Bip, a protein involved in protein folding and ER stress response [ 43 ], resulting in its...

... injury. epitranscriptome RNA-binding proteins stress granules stress response translation translational reprogramming Correspondence: Mariavittoria Pizzinga ( mp540@le.ac.uk ) or Anne Willis ( aew5@le.ac.uk ) * These authors contributed jointly to this work. 4 5 2017 13...

... target recognition. Expression of many sRNAs is positively regulated by stress-responsive sigma factors like RpoE and RpoS, and two-component systems like PhoP/Q, Cpx and Rcs. Some of these regulatory RNAs act via a feedback mechanism on their own regulators, which is best reflected by recent discoveries...

... on evolutionarily conserved pathways. * To whom correspondence should be addressed (email ahagai@agri.huji.ac.il ). 25 1 2016 © 2016 Authors; published by Portland Press Limited 2016 autophagy degradation mitochondria stress response Although mitochondria sport a wide spectrum...

... by Portland Press Limited 2015 antioxidant response element hazard assessment Kelch-like ECH-associated protein 1 (Keap1) nuclear factor erythroid 2-related factor 2 (Nrf2) stress response toxicity The process of evolution has enabled mammalian cells to withstand continuous exposure...

... should be addressed (email a.bikfalvi@angio.u-bordeaux1.fr ). 12 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis chemokine combinatorial therapy resistance to anti-angiogenesis therapy stress response vascular endothelial growth factor (VEGF...

... the expression of stress-responsive genes so that the Bacillus can survive the imposition of stress. Hence the stressosome acts as a hub, receiving manifold different stimuli to effect a single outcome. Using single-particle analysis of cryo-electron micrographs, we have been able to reconstruct a series...

... are microbial stress-response elements, although it was recently shown that knocking out all known chromosomally located TA loci in Escherichia coli did not have an impact on survival under certain types of stress. The hyperthermophilic crenarchaeon Sulfolobus solfataricus encodes at least 26 vapBC (where vap...

... of the genes induced by eIF2 phosphorylation are shared between different environmental stresses, eIF2 kinases function in conjunction with other stress-response pathways, such as those regulated by mitogen-activated protein kinases, to elicit gene expression programmes that are tailored for the specific...