... the Creative Commons Attribution Licence 3.0 . chromatoid body cytoplasmic poly(A)-binding protein 1 (PABPC1) localized translation messenger ribonucleoprotein (mRNP) granules nucleocytoplasmic poly(A)-binding protein (PABP) stress granule Eukaryotic cells rely on post-transcriptional...

...Dipen Rajgor; Catherine M. Shanahan In eukaryotic cells, non-translating mRNAs can accumulate into cytoplasmic mRNP (messenger ribonucleoprotein) granules such as P-bodies (processing bodies) and SGs (stress granules). P-bodies contain the mRNA decay and translational repression machineries...

... be associated with translational repression or activation. Furthermore, mRNA P-bodies (processing bodies) harbour much of the mRNA decay machinery and stress granules are thought to play a role in mRNA storage. In the present review, we explore the process of mRNA localization in the yeast Saccharomyces...

... at the translational level. More recently, we have shown that in cells overexpressing P-glycoprotein, MDR1 mRNA does not aggregate into translationally silent stress granules. Importantly, this is not unique for MDR1 , since other transcripts encoding transmembrane proteins, and which are thus translated...

...-free medium for 45 min. The cells were visualized using a Delta Vision RT (Applied Precision) restoration microscope using a 60×/1.42 Plan Apo objective with the Sedat filter set (Chroma 89000) and images were obtained using a Coolsnap HQCCD camera. Stress granules are similar structures...

... cytoplasmic polyadenylation element-binding protein (CPEB) processing body (P-body) RNA decay stress granule translation initiation Regulation of gene expression at the level of translation is an important level of control in eukaryotes and is essential in early development and in neurons...

...@manchester.ac.uk ). 10 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 EGP-body eukaryotic initiation factor (eIF) mRNA processing body (P-body) stress granule translation initiation In eukaryotic cells, the broad restriction of genetic material...

..., summarize TTP-interacting proteins and discuss how phosphorylation regulates the activity, localization and stability of TTP. AU-rich element cytokine mRNA degradation processing body stress granule tristetraprolin The role of TTP was uncovered by the careful analysis of TTP-knockout mice...

... adenosine deaminase that acts on RNA (ADAR) double-stranded RNA (dsRNA) editing gene expression stress granule translation The role of dsRNA (double-stranded RNA) in cells has been the subject of much recent research following the finding that it is an essential component of the RNAi (RNA...

...N. Kedersha; P. Anderson Mammalian stress granules (SGs) are cytoplasmic domains into which mRNAs are sorted dynamically in response to phosphorylation of eukaryotic initiation factor (eIF) 2α, a key regulatory step in translational initiation. The activation of one or more of the eIF2α kinases...