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Keywords: stress granule
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Articles
Biochem Soc Trans (2015) 43 (6): 1277–1284.
Published: 27 November 2015
... poly(A)-binding protein (PABP) stress granule Eukaryotic cells rely on post-transcriptional control of gene expression to ensure the tight spatiotemporal control of protein production needed to fulfil their functions. One key feature of eukaryotic mRNAs is the co-transcriptionally added 3...
Articles
Biochem Soc Trans (2014) 42 (4): 1206–1210.
Published: 11 August 2014
...Dipen Rajgor; Catherine M. Shanahan In eukaryotic cells, non-translating mRNAs can accumulate into cytoplasmic mRNP (messenger ribonucleoprotein) granules such as P-bodies (processing bodies) and SGs (stress granules). P-bodies contain the mRNA decay and translational repression machineries...
Articles
Biochem Soc Trans (2014) 42 (4): 1256–1260.
Published: 11 August 2014
... be associated with translational repression or activation. Furthermore, mRNA P-bodies (processing bodies) harbour much of the mRNA decay machinery and stress granules are thought to play a role in mRNA storage. In the present review, we explore the process of mRNA localization in the yeast Saccharomyces...
Articles
Biochem Soc Trans (2010) 38 (6): 1537–1542.
Published: 24 November 2010
... at the translational level. More recently, we have shown that in cells overexpressing P-glycoprotein, MDR1 mRNA does not aggregate into translationally silent stress granules. Importantly, this is not unique for MDR1 , since other transcripts encoding transmembrane proteins, and which are thus translated...
Articles
Biochem Soc Trans (2010) 38 (4): 1131–1136.
Published: 26 July 2010
... that are solely involved in glucose fermentation. 26 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 EGP-body glucose derepression mRNA localization processing body (P-body) stress granule translation control Nutrient signalling is intrinsically linked...
Articles
Biochem Soc Trans (2008) 36 (4): 648–652.
Published: 22 July 2008
... that, in general, the translational machinery is largely diffuse within the cytoplasm, with the notable exceptions of eIF2 and eIF2B [ 7 , 19 ]. EGP-body eukaryotic initiation factor (eIF) mRNA processing body (P-body) stress granule translation initiation In eukaryotic cells, the broad...
Articles
Biochem Soc Trans (2008) 36 (4): 671–676.
Published: 22 July 2008
... decay stress granule translation initiation Regulation of gene expression at the level of translation is an important level of control in eukaryotes and is essential in early development and in neurons, in the absence of (local) transcription. Regulation is usually exerted at the initiation...
Articles
Biochem Soc Trans (2008) 36 (3): 534–536.
Published: 21 May 2008
... adenosine deaminase that acts on RNA (ADAR) double-stranded RNA (dsRNA) editing gene expression stress granule translation The role of dsRNA (double-stranded RNA) in cells has been the subject of much recent research following the finding that it is an essential component of the RNAi (RNA...
Articles
Biochem Soc Trans (2008) 36 (3): 491–496.
Published: 21 May 2008
... ]  binds to phosphoserine containing motifs (Ser 52 and Ser 178 in mouse TTP)  inhibits TTP activity  stabilizes TTP protein  enhances cytoplasmic localization of TTP  prevents TTP from associating with stress granules MK2 MAPKAP kinase-2: [ 44 ]  directly phosphorylates TTP...
Includes: Multimedia, Supplementary data
Articles
Biochem Soc Trans (2002) 30 (6): 963–969.
Published: 01 November 2002
...N. Kedersha; P. Anderson Mammalian stress granules (SGs) are cytoplasmic domains into which mRNAs are sorted dynamically in response to phosphorylation of eukaryotic initiation factor (eIF) 2α, a key regulatory step in translational initiation. The activation of one or more of the eIF2α kinases...