... of rapamycin complex 1 (mTORC1) pentose phosphate pathway sterol-regulatory-element-binding protein (SREBP) tumour metabolism The metabolism of all cells, from bacteria to humans, is profoundly different between resting and growing states. A resting cell, such as a naive immune cell...

...Caroline A. Lewis; Beatrice Griffiths; Claudio R. Santos; Mario Pende; Almut Schulze In recent years several reports have linked mTORC1 (mammalian target of rapamycin complex 1) to lipogenesis via the SREBPs (sterol-regulatory-element-binding proteins). SREBPs regulate the expression of genes...

...) metabolism sterol-regulatory-element-binding protein (SREBP) The serine/threonine kinase Akt/PKB (protein kinase B)/c-Akt is activated in response to PI3K signalling and regulates numerous downstream effectors including components of the apoptotic machinery such as Bad, the metabolic regulators GSK3...