... pluripotency regenerative medicine Rho gtpases self-renewal stem cell therapy Mammalian Rho family GTPases are members of the Ras superfamily including over 20 gene products which can be further subdivided into six groups based on sequence identity, domain structure and function: RhoA subfamily...

...Rukmani Sridharan; Jeffrey M. Karp; Weian Zhao For the last decade, stem cell therapies have demonstrated enormous potential for solving some of the most tragic illnesses, diseases and tissue defects worldwide. Currently, more than 1300 clinical trials use stem cell therapy to solve a spectrum...

...-like growth factor) II receptor provides an avenue for endocytosis, trafficking and lysosomal processing of extracellularly delivered enzyme. The present review discusses therapeutic utilization of cross-correction by enzyme-replacement therapy, gene therapy and stem cell therapy for the NCLs, along...