1-18 of 18
Keywords: stem cell
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem Soc Trans (2022) 50 (2): 675–688.
Published: 19 April 2022
...Rajesh Ranjan; Xin Chen Asymmetric cell division (ACD) produces two daughter cells with distinct cell fates. This division mode is widely used during development and by adult stem cells during tissue homeostasis and regeneration, which can be regulated by both extrinsic cues such as signaling...
Articles
Biochem Soc Trans (2021) 49 (4): 1803–1816.
Published: 26 August 2021
... to the presence of slow-cycling cancer stem cells eluding chemo and radiotherapy. Since these malignant stem cells are largely undifferentiated, inducing their lineage commitment has been proposed as a potential intervention strategy to deplete tumours from their most resistant components. Pro-differentiation...
Articles
Biochem Soc Trans (2014) 42 (6): 1629–1636.
Published: 17 November 2014
...) stem cell vascular cell Previous reports have confirmed the role of miRNAs in governing the function of adult PCs. We found that human saphenous vein-derived pericyte PCs (also known as the ‘Bristol pericytes’) have been reported to have therapeutic potential in mouse LI and MI models [ 37...
Articles
Biochem Soc Trans (2014) 42 (4): 809–815.
Published: 11 August 2014
...) therapies effectively inhibit BCR–Abl to control CML in the majority of patients, but do not eliminate the LSC (leukaemic stem cell) population, which becomes quiescent following treatment. Patients require long-term treatment to sustain remission; alternative strategies are therefore required, either alone...
Articles
Biochem Soc Trans (2014) 42 (3): 607–608.
Published: 22 May 2014
... Biochemical Society 2014 aging biochemistry bioengineering regenerative medicine stem cell tissue regeneration The language of biochemistry is changing. Phrases such as ‘intellectual property space,’ ‘tractable targets’ and ‘clinical trial’ have joined the biochemist's vernacular...
Articles
Biochem Soc Trans (2014) 42 (3): 631–635.
Published: 22 May 2014
... be to collect the stem cells at diagnosis, before birth, to be able to intervene during the gestation or in the neonatal period. Human AFSCs (amniotic fluid stem cells), which have characteristics intermediate between those of embryonic and adult stem cells, have been isolated. c-Kit + Lin − cells derived from...
Articles
Biochem Soc Trans (2014) 42 (3): 657–661.
Published: 22 May 2014
... delivered stem cells engraft within lungs, thereby limiting their utility for airway repair. In other organ systems, magnetic targeting has shown promise for improving long-term robust cell engraftment. This technique involves in vitro cell expansion, magnetic actuation and magnetically guided cell...
Articles
Biochem Soc Trans (2014) 42 (3): 663–669.
Published: 22 May 2014
... that govern self-renewal and regeneration may become impaired with age. Tissue-specific SCs (stem cells) lie at the apex of organismal conservation and regeneration, ultimately being responsible for continued tissue maintenance. In many tissues, there are changes in SC numbers, or alteration of their growth...
Articles
Biochem Soc Trans (2014) 42 (3): 637–644.
Published: 22 May 2014
... epithelial cells. These include stratified epithelia, such as the epidermis, hair follicle, cornea and oesophagus, as well as the thymic epithelium, which stands alone among simple and stratified epithelia, and has been shown recently to contain stem cells. In addition, we briefly discuss the pancreas...
Articles
Biochem Soc Trans (2013) 41 (1): 283–287.
Published: 29 January 2013
...Giovanni Camussi; Maria Chiara Deregibus; Vincenzo Cantaluppi The paracrine theory has recently changed the view of the biological action of stem cells and of the subsequent potential application of stem cells in regenerative medicine. Indeed, most of the beneficial effects of stem-cell-based...
Articles
Biochem Soc Trans (2010) 38 (2): 370–373.
Published: 22 March 2010
... by a columnar lined mucosa with intestinal differentiation, usually in the context of chronic gastro-oesophageal reflux disease. The cellular and molecular mechanisms by which this metaplastic transformation occurs are poorly understood. Abnormal differentiation of multipotent stem cells in the squamous...
Articles
Biochem Soc Trans (2010) 38 (2): 613–616.
Published: 22 March 2010
...Bo Sun; Toshiro Ito During early flower development in Arabidopsis , floral stem cells proliferate and produce a sufficient amount of cells that are recruited for organogenesis. However, after the central organ primordia initiate, stem cell activity in the floral meristem is terminated to ensure...
Articles
Biochem Soc Trans (2010) 38 (1): 297–300.
Published: 19 January 2010
... 2010 biomarker cancer lamin stem cell tumour progression BCC basal cell carcinoma CRC colorectal cancer CSC cancer stem cell EC embryonal carcinoma GFP green fluorescent protein HCC hepatocellular carcinoma LINC linker of nucleoskeleton...
Articles
Biochem Soc Trans (2008) 36 (6): 1350–1353.
Published: 19 November 2008
... that lamin A is a putative colonic epithelial stem cell biomarker suggests that the poor outcome associated with lamin A/C-positive tumours may be reflective of a more stem-cell-like phenotype. The present review discusses the link between lamin A expression and tumour progression in one of the commonest...
Articles
Biochem Soc Trans (2008) 36 (4): 613–618.
Published: 22 July 2008
...David Garrick; Marco De Gobbi; Magnus Lynch; Douglas R. Higgs At present, the molecular mechanisms by which stem cells commit to and differentiate towards specific lineages are poorly characterized, and will need to be better understood before stem cells can be exploited fully in experimental...
Articles
Biochem Soc Trans (2008) 36 (3): 363–365.
Published: 21 May 2008
... of how adult stem cells of the pancreas contribute to the maintenance of the pancreatic β-cell pool against the increased metabolic demands associated with obesity may provide new therapeutic targets for treating diabetes. At the same time, if we knew more about the biology of adipocyte formation...
Articles
Biochem Soc Trans (2007) 35 (5): 1347–1351.
Published: 25 October 2007
...H.G. Jørgensen; T.L. Holyoake CML (chronic myeloid leukaemia) is a myeloproliferative disease that originates in an HSC (haemopoietic stem cell) as a result of the t(9;22) translocation, giving rise to the Ph (Philadelphia chromosome) and bcr-abl oncoprotein. The disease starts in CP (chronic phase...
Articles
Biochem Soc Trans (2007) 35 (5): 895–899.
Published: 25 October 2007
... molecules resulting in LDL (low-density lipoprotein) penetration and mononuclear cell infiltration into the sub-endothelial space. Among infiltrated mononuclear cells, there are smooth muscle progenitors that proliferate and differentiate into smooth muscle cells. Meanwhile, stem cells present in the media...