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Keywords: statin
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Articles
Biochem Soc Trans (2014) 42 (4): 1001–1005.
Published: 11 August 2014
..., during oxidative stress, plasma oxycholesterols could have damaging effects on BBB (blood–brain barrier) function and consequently on neuronal cells. Cholesterol-lowering drugs such as statins may prevent the modifications to LDL in mid-life and might show beneficial effects in later life. 1...
Articles
Biochem Soc Trans (2014) 42 (1): 125–129.
Published: 23 January 2014
... clinical evaluation, among which angiogenesis and PARP [poly(ADP-ribose) polymerase] inhibitors appear promising. Pre-clinical studies have identified several potential new therapeutic strategies, and we review the potential for use of BH3 (Bcl-2 homology) mimetics, autotaxin inhibitors and statins...
Articles
Biochem Soc Trans (2012) 40 (3): 587–593.
Published: 22 May 2012
... P450s also catalyse industrially important transformations in the synthesis of cholesterol-lowering statin drugs, with clear benefits to humans. The present article reviews the various roles of P450s in human cholesterol metabolism, from endogenous P450s through to microbial oxidases that enable...
Articles
Biochem Soc Trans (2007) 35 (6): 1529–1532.
Published: 23 November 2007
...K. Wikhe; C. Westermeyer; I.G. Macreadie The statins, simvastatin and atorvastatin are the most widely prescribed drugs. Statins lower cholesterol levels through their action on HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase, an essential enzyme for the biosynthesis of cholesterol. Fungal HMG...
Articles
Biochem Soc Trans (2003) 31 (5): 1066–1069.
Published: 01 October 2003
... substrate for hepatic lipase; if the activity of the enzyme is high enough, lipolysis will generate smaller, denser particles. Correction of the dyslipidaemia associated with small, dense LDL is possible using fibrates and statins, and this may contribute to the clinical benefits seen with these drugs...
Articles
Biochem Soc Trans (2003) 31 (5): 1080–1084.
Published: 01 October 2003
... of the Biochemical Society's Irish Area Section held at Royal College of Surgeons in Ireland, Dublin, 25–26 June 2003 3 June 2003 © 2003 Biochemical Society 2003 arterial wall atherosclerosis fibrate statin triacylglycerol lowering triacylglycerol-rich lipoprotein Abbreviations...
Articles
Biochem Soc Trans (2003) 31 (3): 528–531.
Published: 01 June 2003
...G.A. Holdgate; W.H.J. Ward; F. McTaggart The statins are inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (HMG-CoAR), and are utilized to decrease levels of atherogenic lipoproteins in patients with, or who are at high risk of, cardiovascular disease. This study describes...
Articles
Biochem Soc Trans (2002) 30 (4): 525–529.
Published: 01 August 2002
... 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), termed statins, can inhibit Aβ production. Increasing evidence suggests that the enzymes that generate Aβ function best in a high-cholesterol environment, which might explain why reducing cholesterol would inhibit Aβ production. Studies...