1-17 of 17
Keywords: splicing
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem Soc Trans (2022) 50 (5): 1447–1456.
Published: 25 October 2022
... to undergo others. Furthermore, alternative splicing and/or cleavage and polyadenylation can produce transcripts with alternative messages and new functionalities. The coordinated processing of groups of functionally related RNAs can potently re-wire signalling pathways, modulate survival pathways and even...
Articles
Biochem Soc Trans (2018) 46 (6): 1407–1422.
Published: 12 November 2018
..., catalysis, and active site formation. This has advanced our mechanistic understanding of pre-mRNA splicing enormously. Correspondence: Wojciech P. Galej ( wgalej@embl.fr ) 23 8 2018 24 9 2018 25 9 2018 The above reactions are catalysed by a multi-subunit RNA–protein complex...
Articles
Biochem Soc Trans (2017) 45 (6): 1313–1321.
Published: 17 November 2017
... 23 10 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 helicase RNA structure self-splicing intron splicing unwinding Structured RNAs carry out a wide range of regulatory and catalytic functions in all domains of life...
Articles
Biochem Soc Trans (2015) 43 (6): 1259–1265.
Published: 27 November 2015
... is well recognized as causal for neurodevelopmental disorders (NDDs). Recent studies have shown that aberrant gene expression can also lead to disorders of neural development. Here we summarize recent evidence implicating in the aetiology of NDDs mutation of factors acting at the level of mRNA splicing...
Articles
Biochem Soc Trans (2012) 40 (4): 846–849.
Published: 20 July 2012
...Steven West Splicing is a key process for mRNA maturation, particularly in higher eukaryotes where most protein-coding transcripts contain multiple introns. It is achieved by the concerted action of five snRNAs (small nuclear RNAs) and hundreds of accessory proteins that form the spliceosome...
Articles
Biochem Soc Trans (2012) 40 (4): 759–761.
Published: 20 July 2012
...Natalia Gromak Most human genes transcribed by RNA Pol II (polymerase II) contain short exons separated by long tracts of non-coding intronic sequences. In addition to their role in generating proteomic diversity through the process of alternative splicing, intronic sequences host many ncRNAs (non...
Articles
Biochem Soc Trans (2010) 38 (6): 1543–1547.
Published: 24 November 2010
... issue. 7 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 ribosomal protein ribosome splicing transcription translation 1 To whom correspondence should be addressed (email s.brogna@bham.ac.uk ). DFC dense fibrillar component Nus...
Articles
Biochem Soc Trans (2010) 38 (4): 1105–1109.
Published: 26 July 2010
...Daniela Hahn; Jean D. Beggs RNA helicases are involved in many cellular processes. Pre-mRNA splicing requires eight different DExD/H-box RNA helicases, which facilitate spliceosome assembly and remodelling of the intricate network of RNA rearrangements that are central to the splicing process...
Articles
Biochem Soc Trans (2010) 38 (1): 237–241.
Published: 19 January 2010
... the spliceosome to decode pre-mRNAs into alternatively spliced mRNAs. Recent post-genomic technology has exposed the complexity of nuclear RNA processing, and is starting to reveal the mechanisms and rules through which networks of RNA-binding proteins can regulate multiple parallel pathways. Identification...
Articles
Biochem Soc Trans (2009) 37 (4): 756–761.
Published: 22 July 2009
... rates and amino acid choice. Exploring the role of selection at the DNA and RNA level, we specifically address how the need (i) to specify exonic splice enhancer motifs in pre-mRNA, and (ii) to ensure nucleosome positioning on DNA have an impact on amino acid choice and rates of evolution. For both, we...
Articles
Biochem Soc Trans (2008) 36 (3): 546–547.
Published: 21 May 2008
... e.clark@ncl.ac.uk ). 15 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Current models of gene transcription suggest that transcriptional initiation, elongation and RNA splicing are tightly coupled [ 9 – 11 ]. In light of this, it is highly probable that the AR...
Articles
Biochem Soc Trans (2008) 36 (3): 514–516.
Published: 21 May 2008
... is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the current understanding in view of recent developments. 1 To whom...
Articles
Biochem Soc Trans (2006) 34 (1): 45–47.
Published: 20 January 2006
... partners of gephyrin have been identified. The mechanisms by which these interactions occur are unclear at present. Alternative splicing has been proposed to contribute to gephyrin's functional diversity within single cells as well as in different cell types and tissues. The gephyrin gene encodes...
Articles
Biochem Soc Trans (2005) 33 (3): 439–442.
Published: 01 June 2005
...A. Krämer; F. Ferfoglia; C.-J. Huang; F. Mulhaupt; D. Nesic; G. Tanackovic Human splicing factor SF3a is a part of the 17 S U2 snRNP (small nuclear ribonucleoprotein), which interacts with the pre-mRNA branch site early during spliceosome formation. The SF3a subunits of 60, 66 and 120 kDa are all...
Articles
Biochem Soc Trans (2005) 33 (3): 433–438.
Published: 01 June 2005
... that affect pre-mRNA splicing and degradation, small nucleolar RNA, tRNA processing, rRNA processing and mRNA degradation. These activities suggest RNA chaperone-like roles for Lsm proteins, affecting RNA–RNA and/or RNA–protein interactions. This article reviews the properties of the Sm and Lsm proteins...
Articles
Biochem Soc Trans (2004) 32 (6): 924–927.
Published: 26 October 2004
...P.J. Grabowski Alternative pre-mRNA splicing is frequently used to expand the protein-coding capacity of genomes, and to regulate gene expression at the post-transcriptional level. It is a significant challenge to decipher the molecular language of tissue-specific splicing because the inherent...
Articles
Biochem Soc Trans (2002) 30 (6): 1162–1166.
Published: 01 November 2002
...T. R. Cech In 1982 we reported the first catalytic RNA or ribozyme: the self-splicing intron of the Tetrahymena pre-rRNA. Additional examples of natural ribozymes were soon found, and research in the field focused on their enzymic mechanism and secondary and tertiary structure. Ribozymes identified...