... and the involved factors during splicing remain elusive. Recently published structures of the human C* spliceosome clarified the position of the EJC at this phase of splicing and have given insight into previously unidentified interactions between the EJC and spliceosomal proteins. Here, these new observations...

... nucleosome RNA polymerase small nuclear ribonucleoprotein particle (snRNP) spliceosome Considering the growing body of evidence suggesting a three-way cross-talk between transcription, splicing and chromatin, it would be beneficial to adopt a systems biology approach to integrate the large amount...

...Rebecca Hogg; Joanne C. McGrail; Raymond T. O'Keefe The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate...

... splice site recognition pre-mRNA maturation spliceosome splice site U1 small nuclear ribonucleoprotein (U1 snRNP) Introns are removed during pre-mRNA maturation through two transesterification reactions where snRNPs (small nuclear ribonucleopreteins) and additional factors associate to form...

...Lily Novak Frazer; Verity Nancollis; Raymond T. O'Keefe Pre-mRNA splicing is an essential step in gene expression where intron regions are removed and coding exon sequences are joined to form an mRNA for translation. Splicing is catalysed by an RNA–protein complex called the spliceosome. A number...

...S.E. Butcher; D.A. Brow The spliceosome catalyses the splicing of nuclear pre-mRNA (precursor mRNA) in eukaryotes. Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The spliceosome...

...-mRNA splicing occurs in the nucleus and is catalysed by complex ribonucleoprotein machines called spliceosomes. These molecular machines consist of several small nuclear RNA molecules and their associated proteins [together termed snRNP (small nuclear ribonucleoprotein) particles], plus multiple...