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Keywords: spliceosome
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Biochem Soc Trans (2018) 46 (1): 153–161.
Published: 19 January 2018
... and the involved factors during splicing remain elusive. Recently published structures of the human C* spliceosome clarified the position of the EJC at this phase of splicing and have given insight into previously unidentified interactions between the EJC and spliceosomal proteins. Here, these new observations...
Biochem Soc Trans (2010) 38 (5): 1251–1256.
Published: 24 September 2010
... compilation © 2010 Biochemical Society 2010 coupling histone modification nucleosome RNA polymerase small nuclear ribonucleoprotein particle (snRNP) spliceosome When protein encoding transcripts are produced by RNAPII (RNA polymerase II), they are subject to processing at their 5′-ends...
Biochem Soc Trans (2010) 38 (4): 1110–1115.
Published: 26 July 2010
...Rebecca Hogg; Joanne C. McGrail; Raymond T. O'Keefe The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate...
Biochem Soc Trans (2008) 36 (3): 548–550.
Published: 21 May 2008
... for aberrant splicing even in those cases where the variant is not thought to alter the U1 snRNA interaction. In the formation of the pre-spliceosome, the 5′-end of the U1 RNA base pairs with the 5′ junction (donor site or 5′ splice site), whereas other spliceosomal components U4/U5/U6 interact...
Biochem Soc Trans (2008) 36 (3): 551–553.
Published: 21 May 2008
...Lily Novak Frazer; Verity Nancollis; Raymond T. O'Keefe Pre-mRNA splicing is an essential step in gene expression where intron regions are removed and coding exon sequences are joined to form an mRNA for translation. Splicing is catalysed by an RNA–protein complex called the spliceosome. A number...
Biochem Soc Trans (2005) 33 (3): 447–449.
Published: 01 June 2005
...S.E. Butcher; D.A. Brow The spliceosome catalyses the splicing of nuclear pre-mRNA (precursor mRNA) in eukaryotes. Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The spliceosome...
Biochem Soc Trans (2004) 32 (6): 928–931.
Published: 26 October 2004
...-mRNA splicing occurs in the nucleus and is catalysed by complex ribonucleoprotein machines called spliceosomes. These molecular machines consist of several small nuclear RNA molecules and their associated proteins [together termed snRNP (small nuclear ribonucleoprotein) particles], plus multiple...