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Keywords: spindle assembly checkpoint
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Articles
Biochem Soc Trans (2013) 41 (6): 1755–1760.
Published: 20 November 2013
...Silke Hauf The spindle assembly checkpoint is a conserved mitotic signalling pathway that ensures the equal segregation of chromosomes to daughter cells. Despite intensive work in many model organisms, key features of this safety mechanism remain unexplained. In the present review, I briefly...
Articles
Biochem Soc Trans (2010) 38 (6): 1667–1675.
Published: 24 November 2010
... in order to understand the evolutionary adaptations that may have occurred in KMN structure. centromere chromosome segregation kinetochore mitosis sister chromatid spindle assembly checkpoint Eukaryotic centromeres are highly variable in size and sequence and centromeric DNA does...
Articles
Biochem Soc Trans (2010) 38 (6): 1645–1649.
Published: 24 November 2010
...Valentina Rossio; Elena Galati; Simonetta Piatti Many cancer-treating compounds used in chemotherapies, the so-called antimitotics, target the mitotic spindle. Spindle defects in turn trigger activation of the SAC (spindle assembly checkpoint), a surveillance mechanism that transiently arrests...
Articles
Biochem Soc Trans (2010) 38 (6): 1715–1721.
Published: 24 November 2010
... (structural CIN), and gains and losses of whole chromosomes (numerical CIN or nCIN). The present review focuses on the causes and consequences of nCIN. Several roads can lead to nCIN, including a compromised spindle assembly checkpoint, cohesion defects, p53 deficiency and flawed microtubule–kinetochore...
Articles
Biochem Soc Trans (2010) 38 (6): 1650–1654.
Published: 24 November 2010
... with a non-exposed group of children [ 43 ]. © The Authors Journal compilation © 2010 Biochemical Society 2010 aneuploidy cancer chromosome instability metal carcinogenesis spindle assembly checkpoint One study showed an increase of lagging chromosomes, indicative of microtubule...
Articles
Biochem Soc Trans (2010) 38 (6): 1660–1666.
Published: 24 November 2010
... activity in the regulation of the mitotic checkpoint and KT–MT interactions [ 43 – 46 ]. Aurora B kinase centromere chromosomal passenger complex (CPC) kinetochore mitotic checkpoint spindle assembly checkpoint Figure 3 Model of the role of CPC relocation in preventing mitotic...
Articles
Biochem Soc Trans (2006) 34 (4): 583–586.
Published: 21 July 2006
... spindle assembly checkpoint BubR1 expression is extremely high in testes and ovaries of young animals but, as mice age, BubR1 levels progressively decline in these organs [ 33 ]. Bub3 and Rae1 levels are also high in testis and ovary, but in contrast with BubR1, these checkpoint proteins remain...