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Keywords: sphingolipid
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Biochem Soc Trans (2023) 51 (3): 1279–1287.
Published: 14 June 2023
... the different stages of phagocytosis, the lipidome however, remained lesser explored, until the past few years. In this review, we summarize recent efforts towards mapping the physiological roles and functions of three lipid classes, the phosphatidylinositols, cholesterol and sphingolipids during the various...
Biochem Soc Trans (2014) 42 (5): 1401–1408.
Published: 18 September 2014
...Félix M. Goñi; Jesús Sot; Alicia Alonso Some of the simplest sphingolipids, namely sphingosine, ceramide and their phosphorylated compounds [sphingosine 1-phosphate (Sph-1-P) and ceramide 1-phosphate (Cer-1-P)], are potent metabolic regulators. Each of these lipids modifies in marked and specific...
Biochem Soc Trans (2013) 41 (6): 1562–1568.
Published: 20 November 2013
...Konrad Sandhoff Lysosomes are cellular stomachs. They degrade macromolecules and release their components as nutrients into the cytosol. Digestion of sphingolipids and other membrane lipids occurs at luminal intraendosomal vesicles and IMs (intraendosomal membranes). Sphingolipid and membrane...
Biochem Soc Trans (2012) 40 (3): 547–554.
Published: 22 May 2012
...Jonathan Lowther; James H. Naismith; Teresa M. Dunn; Dominic J. Campopiano SLs (sphingolipids) are composed of fatty acids and a polar head group derived from L -serine. SLs are essential components of all eukaryotic and many prokaryotic membranes but S1P (sphingosine 1-phosphate) is also a potent...
Biochem Soc Trans (2009) 37 (5): 955–960.
Published: 21 September 2009
.... As a case in point, the concept of lipid rafts has received considerable attention from biologists and biophysicists since the formalization of the hypothesis more than 10 years ago. Today, it is clear that sphingolipid and cholesterol can self-associate into micron-scaled phases in model membranes...
Biochem Soc Trans (2007) 35 (5): 908–909.
Published: 25 October 2007
...G.F. Nixon; F.A. Mathieson; I. Hunter Increasing experimental evidence has demonstrated that sphingolipids are likely to have an important regulatory function in the cardiovascular system. Two sphingolipids released from activated platelets, and therefore of particular relevance, are S1P...
Biochem Soc Trans (2006) 34 (3): 356–358.
Published: 22 May 2006
... Avenue, New York, NY 10021, U.S.A. (email akm2003@med.cornell.edu ). 13 12 2005 © 2006 The Biochemical Society 2006 endoplasmic reticulum ergosterol Osh protein sphingolipid sterol trafficking yeast Lipids are trafficked between intracellular compartments via secretory...
Biochem Soc Trans (2005) 33 (5): 1219–1223.
Published: 26 October 2005
...R. Pasrija; T. Prasad; R. Prasad By exploiting the biosynthetic pathways of raft lipid constituents, in this study we demonstrate that fluctuations in either sphingolipid or ergosterol levels result in increased drug sensitivity and morphological defects in Candida albicans cells. We show that any...
Biochem Soc Trans (2005) 33 (5): 1166–1169.
Published: 26 October 2005
...L.A. Cowart; Y.A. Hannun In addition to their crucial role in membrane structure in Saccharomyces cerevisiae , sphingolipids serve vital roles in various aspects of yeast biology including endocytosis, intracellular protein transport and stress responses. Although previous studies have...
Biochem Soc Trans (2005) 33 (5): 1170–1173.
Published: 26 October 2005
...K. Liu; X. Zhang; C. Sumanasekera; R.L. Lester; R.C. Dickson Over the past several years, studies of sphingolipid functions in the baker's yeast Saccharomyces cerevisiae have revealed that the sphingoid LCBs (long-chain bases), dihydrosphingosine and PHS (phytosphingosine), are important signalling...
Biochem Soc Trans (2005) 33 (5): 1178–1181.
Published: 26 October 2005
... the knowledge of regulatory mechanisms of the biosynthetic pathway and its interactions with other lipid pathways like those of sphingolipids, phospholipids and fatty acids are crucial. Eisenkolb et al. [ 17 ] reported that an erg6 deletion mutant that is normally viable and uses zymosterol as its major...
Biochem Soc Trans (2004) 32 (1): 65–69.
Published: 01 February 2004
...C.J. Fielding; P.E. Fielding The plasma membrane of mammalian cells consists of microdomains differing in lipid and protein composition. Two distinct classes of cholesterol/sphingolipid microdomain (caveolae and lipid rafts) are assembly points for transmembrane signalling complexes. Recent...