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Keywords: small molecules
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Biochem Soc Trans (2022) 50 (1): 439–446.
Published: 07 January 2022
... BY) . chronic kidney disease fibroblast growth factors heart failure hypertension phosphate small molecules Plasma phosphate (P i ) is tightly controlled in the range from 0.9 to 1.45 mmol L −1 in healthy adults [ 1 ], and requires a concerted interplay between intestinal uptake, storage/release...
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Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 membranes small gtpases small molecules structural biology trafficking Cytoplasmic small GTPases and most of their interacting proteins belong to the broad class of peripheral membrane proteins, which...
Articles
Biochem Soc Trans (2020) 48 (5): 1859–1875.
Published: 11 September 2020
... inhibitors (ERK5i). However, few ERK5i programmes have taken account of the ERK5 transactivation domain. We have recently shown that the binding of small molecule ERK5i to the ERK5 kinase domain stimulates nuclear localisation and paradoxical activation of its transactivation domain. Other kinase inhibitors...
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Biochem Soc Trans (2019) 47 (2): 733–741.
Published: 18 April 2019
... such as obesity, type 2 diabetes and inflammatory disorders, which has prompted a major drive to develop pharmacological activators of AMPK. An array of small-molecule allosteric activators has now been developed, several of which can activate AMPK by direct allosteric activation, independently of Thr172...
Articles
Biochem Soc Trans (2017) 45 (1): 79–88.
Published: 15 February 2017
... and PAK3 and ∼54% with PAK4,5,6), it is not surprising that the majority of described PAK1 targeting small molecules either inhibit all Paks (‘pan-Pak’) or are group-specific (e.g. PAK1/2/3 inhibitors) [ 2 , 13 ] ( Figure 3 ). Figure 2. Co-crystal structures of ATP-competitive Pak inhibitors...