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Keywords: small molecule
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Biochem Soc Trans (2021) 49 (6): 2627–2638.
Published: 23 November 2021
... development of the technique. biologics cryo-EM drug discovery and design small molecule vaccines Structure-based drug design (SBDD) has been an essential tool in pharmaceutical development for decades. Structures of macromolecular drug targets, especially when bound to modulators, can reveal...
Biochem Soc Trans (2014) 42 (6): 1756–1761.
Published: 17 November 2014
... The Authors Journal compilation © 2014 Biochemical Society 2014 chemical genetics enolase glyceraldehyde-3-phosphate dehydrogenase (GAPDH) glycolysis moonlighting small molecule The glycolysis metabolic pathway is a highly conserved, ancient metabolic pathway that catabolizes one mole...
Biochem Soc Trans (2012) 40 (5): 1004–1008.
Published: 19 September 2012
... for rational drug discovery approaches. Consequently, structure-based drug design efforts to date have mostly focused on inhibiting interactions of IDPs with other proteins whose structure can be solved by conventional biophysical methods. Yet, in recent years, several examples of small molecules that bind...
Biochem Soc Trans (2004) 32 (2): 348–349.
Published: 01 April 2004
... and the phosphatidylinositol 3-phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10). Specific inhibitors targeting phosphoinositide 3-kinase and protein phosphatases have been described and characterized, but no small-molecule tools for phosphoinositide phosphatases are currently available. The present...