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Keywords: small gtpases
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Biochem Soc Trans (2021) 49 (5): 2021–2035.
Published: 08 October 2021
...Marie Sorbara; Nicolas Bery The RAS superfamily of small GTPases regulates major physiological cellular processes. Mutation or deregulation of these small GTPases, their regulators and/or their effectors are associated with many diseases including cancer. Hence, targeting these classes of proteins...
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...Agata Nawrotek; Mahel Zeghouf; Jacqueline Cherfils Small GTPases, in association with their GEFs, GAPs and effectors, control major intracellular processes such as signal transduction, cytoskeletal dynamics and membrane trafficking. Accordingly, dysfunctions in their biochemical properties...