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Keywords: silencing
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Biochem Soc Trans (2019) 47 (4): 1187–1196.
Published: 05 July 2019
...Silvia Costa; Caroline Dean Polycomb-mediated epigenetic silencing is central to correct growth and development in higher eukaryotes. The evolutionarily conserved Polycomb repressive complex 2 (PRC2) transcriptionally silences target genes through a mechanism requiring the histone modification...
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Biochem Soc Trans (2004) 32 (6): 924–927.
Published: 26 October 2004
... exon silencing mechanism. We identify a set of guanosine-rich motifs that function co-operatively to regulate the CI cassette exon in a manner consistent with its in vivo splicing pattern. Whereas hnRNP (heterogeneous nuclear ribonucleoprotein) A1 mediates silencing of the CI cassette exon...