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Keywords: signalling
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Articles
Biochem Soc Trans (2022) BST20211225.
Published: 13 June 2022
... by small interfering RNAs targeting ARNT or by activating AHR or HIF1α signaling to compete for binding to ARNT, reduced the transcription activity of ERs [ 83 ]. Together, these results suggest that ARNT acts as a transcriptional coregulator for nuclear estrogen receptors, separate from its role as a bHLH...
Articles
Biochem Soc Trans (2022) BST20211115.
Published: 19 May 2022
... interactions to signal apoptosis. Fas/CD95 death receptor-mediated apoptosis requires the formation of the so-called d eath- i nducing s ignaling c omplex (DISC), bringing together Fas/CD95, Fas-associated death domain-containing protein and procaspase-8. In the last two decades, cholesterol-rich lipid raft...
Articles
Biochem Soc Trans (2021) 49 (3): 1171–1188.
Published: 22 June 2021
... in PKD is due to mutations in cilia-localising genes, resulting in changes in cellular signalling. As such, compounds that are currently in preclinical and clinical trials target some of these signalling pathways that are dysregulated in PKD. In this review, we highlight these pathways including cAMP...
Articles
Biochem Soc Trans (2021) 49 (3): 1385–1395.
Published: 01 June 2021
... to be considered as therapeutic targets. In the past two decades, around 45 drugs targeting chemokine receptors have been developed, yet only three are clinically approved. The challenging factors include the limited understanding of aberrant chemokine signalling in malignant diseases, high redundancy...
Articles
Biochem Soc Trans (2022) 50 (1): 335–345.
Published: 11 January 2021
... sciences. In recent years, the chemogenetic DAAO approach has proven beneficial to establish a new role for (patho)physiological oxidative stress on redox-dependent signaling and metabolic pathways in cultured cells and animal model systems. This mini-review covers established or emerging methods...
Articles
Biochem Soc Trans (2020) 48 (5): 2015–2027.
Published: 14 October 2020
... by Leucine carboxyl methyltransferase-1 (LCMT1) that utilizes S-adenosyl-methionine (SAM) as the methyl donor and removed by protein phosphatase methylesterase 1 (PME1). For PP2A, methylation dictates regulatory subunit selection and thereby downstream phosphorylation signaling. Intriguingly, there are four...
Articles
Biochem Soc Trans (2020) 48 (5): 2051–2066.
Published: 11 September 2020
...Harrison M. York; Joanne Coyle; Senthil Arumugam Living cells interpret a variety of signals in different contexts to elucidate functional responses. While the understanding of signalling molecules, their respective receptors and response at the gene transcription level have been relatively well...
Articles
Biochem Soc Trans (2020) 48 (1): 95–101.
Published: 12 February 2020
..., voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction . Biophys. J. 88 , 2614 – 2625 10.1529/biophysj.104.057281 35 Holmström , K.M. , Marina , N. , Baev , A.Y. , Wood , N.W. , Gourine , A.V. and Abramov , A.Y. ( 2013 ) Signalling...
Articles
Biochem Soc Trans (2019) 47 (5): 1291–1305.
Published: 28 October 2019
...David Barneda; Sabina Cosulich; Len Stephens; Phillip Hawkins The phosphoinositide (PIPn) family of signalling phospholipids are central regulators in membrane cell biology. Their varied functions are based on the phosphorylation pattern of their inositol ring, which can be recognized by selective...
Articles
Biochem Soc Trans (2019) 47 (5): 1355–1366.
Published: 11 October 2019
... is spatially and temporally controlled in cells. Obtaining a detailed understanding of the molecular basis of PKA targeting may reveal novel strategies for pharmacological targeting of cAMP signalling. PKA activity is controlled in part by association with AKAP proteins, but anchoring does not directly...
Articles
Biochem Soc Trans (2019) 47 (5): 1415–1427.
Published: 11 October 2019
...Urszula Luchowska-Stańska; David Morgan; Stephen J. Yarwood; Graeme Barker The cellular signalling enzymes, EPAC1 and EPAC2, have emerged as key intracellular sensors of the secondary messenger cyclic 3′,5′-adenosine monophosphate (cyclic adenosine monophosphate) alongside protein kinase...
Articles
Biochem Soc Trans (2018) 46 (6): 1673–1680.
Published: 04 December 2018
...Lilian Schimmel; Emma Gordon Endothelial cell–cell adhesion within the wall of the vasculature controls a range of physiological processes, such as growth, integrity and barrier function. The adhesive properties of endothelial cells are tightly controlled by a complex cascade of signals transmitted...
Articles
Biochem Soc Trans (2018) 46 (6): 1681–1695.
Published: 12 November 2018
... on target proteins or in the form of ADP-ribose chains, with the latter called poly(ADP-ribosyl)ation. PARPs regulate many cellular processes, including the maintenance of genome stability and signal transduction. In this review, we focus on the PARP family members that possess the ability to modify...
Articles
Biochem Soc Trans (2018) 46 (5): 1325–1332.
Published: 04 October 2018
...Stephanie P. Mo; Judy M. Coulson; Ian A. Prior RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent...
Articles
Biochem Soc Trans (2018) 46 (5): 1063–1072.
Published: 21 September 2018
...Christian Makhoul; Prajakta Gosavi; Paul A. Gleeson An array of signalling molecules are located at the Golgi apparatus, including phosphoinositides, small GTPases, kinases, and phosphatases, which are linked to multiple signalling pathways. Initially considered to be associated predominantly...
Articles
Biochem Soc Trans (2018) 46 (2): 391–401.
Published: 14 March 2018
... specificities recognised by CAR-T cells will broaden tumour antigen coverage, potentially overcoming tumour heterogeneity and limiting tumour antigen escape. Tuning the balance of signalling within bi-specific CAR-T cells may enable tumour targeting while sparing normal tissues, and thus minimise on-target, off...
Articles
Biochem Soc Trans (2018) 46 (2): 453–466.
Published: 22 February 2018
...Miriam Walden; Safi Kani Masandi; Krzysztof Pawłowski; Elton Zeqiraj The ubiquitin (Ub) proteasome system and Ub signalling networks are crucial to cell biology and disease development. Deubiquitylases (DUBs) control cell signalling by removing mono-Ub and polyubiquitin chains from substrates. DUBs...
Includes: Supplementary data
Articles
Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
... of the Biochemical Society 2017 deubiquitylase mass spectrometry proteomics signalling SUMOylation ubiquitins Ubiquitylation is a post-translational modification involving the covalent binding of the small, highly conserved protein ubiquitin, consisting of 76 amino acids, to a target substrate...
Articles
Biochem Soc Trans (2017) 45 (3): 665–681.
Published: 15 June 2017
...Annette V. Jacobsen; James M. Murphy Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise ∼10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies...
Articles
Biochem Soc Trans (2016) 44 (1): 293–298.
Published: 09 February 2016
...-established and potential new roles for phosphoinositides in β-cell function/dysfunction and discuss how our knowledge of phosphoinositide signalling could aid in the identification of potential strategies for treating or preventing type 2 diabetes. β-cell insulin lipid kinases nutrients obesity...
Articles
Biochem Soc Trans (2016) 44 (1): 13–17.
Published: 09 February 2016
... conditions. Polyphosphorylation detection was only possible through extensive biochemical characterization. Two targets have been identified: nuclear signal recognition 1 (Nsr1) and its interacting partner, topoisomerase 1 (Top1). Polyphosphorylation occurs within a conserved N-terminal p oly a cidic serine...
Articles
Biochem Soc Trans (2015) 43 (5): 1049–1050.
Published: 09 October 2015
...Endre Kiss-Toth; Guillermo Velasco; Warren S. Pear 1 To whom correspondence should be addressed (email e.kiss-toth@sheffield.ac.uk ) . 2 6 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer lipids metabolism signalling tribbles ubiquitin...
Articles
Biochem Soc Trans (2015) 43 (5): 1051–1056.
Published: 09 October 2015
...Andrew D. Rowan; Gary J. Litherland The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction...
Articles
Biochem Soc Trans (2015) 43 (4): 687–689.
Published: 03 August 2015
... physiological and pathological processes has become widely recognized; these include redox signalling and redox homoeostasis, drug metabolism and disposition, intermediary metabolism, cellular adaptation to stress, chemoprevention and chemoresistance, toxicity, inflammation, neurodegeneration, lipogenesis...
Articles
Biochem Soc Trans (2015) 43 (1): 97–103.
Published: 26 January 2015
... to nutrient signalling, thus coupling environmental stimuli to secretory capacity. 1 To whom correspondence should be addressed (email c.rabouille@hubrecht.eu ) . 10 11 2014 To understand how Sec16 carries out its function in COPII coat dynamics, domains are being mapped. Three domains...
Articles
Biochem Soc Trans (2014) 42 (5): 1311–1315.
Published: 18 September 2014
..., the signalling pathways eliciting glycogen degradation inside astrocytes are themselves energy-demanding processes, a fact that has been emphasized in recent studies, demonstrating dependence of these signalling mechanisms on glycogenolytic ATP. GP was first characterized in the 1930s by Cori et al. [ 10...
Articles
Biochem Soc Trans (2014) 42 (5): 1349–1355.
Published: 18 September 2014
...-kinase (PI3K)/Akt signalling cascade. Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell survival, growth, proliferation and metabolism. Strikingly, non-redundant and even opposing functions of Akt isoforms in the regulation of phenotypes associated...
Articles
Biochem Soc Trans (2014) 42 (4): 934–938.
Published: 11 August 2014
... with such signalling properties, and this molecule has been shown to affect a wide range of cellular functions. Its localized synthesis by the Nox (NADPH oxidase) family of enzymes and how these enzymes are regulated is of particular interest to those who work in the field of tumour biology. Cellular processes...
Articles
Biochem Soc Trans (2014) 42 (4): 733–741.
Published: 11 August 2014
... be the result of genomic alterations such as PIK3CA mutation, PTEN (phosphatase and tensin homologue deleted on chromosome 10) loss or the activation of upstream protein tyrosine kinases. Not surprisingly, the PI3K signalling pathway has become an attractive therapeutic target, and numerous inhibitors...
Articles
Biochem Soc Trans (2014) 42 (4): 846–850.
Published: 11 August 2014
...John A. Pickett; Stephen Barasa; Michael A. Birkett The interaction between volatile and non-volatile, e.g. proteinaceous, components of pheromone and other semiochemical-based signalling systems presents a daunting set of problems for exploitation in the management of vertebrates, good or bad...
Articles
Biochem Soc Trans (2014) 42 (4): 965–970.
Published: 11 August 2014
... (reactive nitrogen species) necessary for the regulation of many proteins involved in excitation–contraction coupling. The magnitude and species of ROS/RNS generated by contracting muscles will have downstream effects on specific protein targets and cellular redox signalling. Redox modifications on specific...
Articles
Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
...Rebecca J. Holley; Kate A. Meade; Catherine L.R. Merry Differentiation and subsequent specialization of every cell within an organism is an intricate interwoven process. A complex network of signalling pathways eventually leads to the specification of a multitude of different cell types able...
Articles
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling cAMP signals are transduced via three receptor proteins: the CNG (cyclic-nucleotide-gated) channels, Epacs (exchange proteins directly activated by cAMP) and PKA (protein kinase A). Both Epac and PKA...
Articles
Biochem Soc Trans (2014) 42 (2): 302–307.
Published: 20 March 2014
...-dependent signalling pathways has a high translational potential. However, the ubiquity of eukaryotic CBDs also poses a challenge in terms of selectivity. Before the full translational potential of cAMP signalling can be tapped, it is critical to understand the structural basis for selective cAMP agonism...
Articles
Biochem Soc Trans (2013) 41 (6): 1489–1494.
Published: 20 November 2013
... differentiation ( Table 1 ). autophagy degradation development embryogenesis neurogenesis signalling Autophagy is an evolutionarily conserved pathway that delivers cytoplasmic substrates, such as damaged organelles and cytoplasmic proteins, to lysosomes for degradation. Three classes...
Articles
Biochem Soc Trans (2013) 41 (4): 887–888.
Published: 18 July 2013
.... Loewith R. Schmidt A. Lin S. Rüegg M.A. Hall A. Hall M.N. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive Nat. Cell Biol. 2004 6 1122 1128 9 Wullschleger S. Loewith R. Hall M.N. TOR signaling in growth and metabolism...
Articles
Biochem Soc Trans (2013) 41 (4): 995–1001.
Published: 18 July 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 actin cell adhesion extracellular matrix integrin-linked kinase (ILK) pseudokinase signalling In order to establish and maintain structural organization and proper function of the tissue, cells need to sense and process...
Articles
Biochem Soc Trans (2013) 41 (4): 939–943.
Published: 18 July 2013
... translation. In order for cells to control cellular homoeostasis during growth, there is close signalling interplay between mTORC1 and two other protein kinases, AMPK (AMP-activated protein kinase) and ULK1 (Unc-51-like kinase 1). This kinase triad collectively senses the energy and nutrient status...
Articles
Biochem Soc Trans (2013) 41 (4): 1002–1007.
Published: 18 July 2013
...Olli Silvennoinen; Daniela Ungureanu; Yashavanthi Niranjan; Henrik Hammaren; Rajintha Bandaranayake; Stevan R. Hubbard JAK (Janus kinase) 2 plays a critical role in signal transduction through several cytokine receptors. JAKs contain a typical tyrosine kinase domain preceded by a pseudokinase [JH2...
Articles
Biochem Soc Trans (2013) 41 (1): 144–147.
Published: 29 January 2013
...Sophie Mary; Jean-Alain Fehrentz; Marjorie Damian; Pascal Verdié; Jean Martinez; Jacky Marie; Jean-Louis Banères The dynamic character of GPCRs (G-protein-coupled receptors) is essential to their function. However, the details of how ligands and signalling proteins stabilize a receptor conformation...
Articles
Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... to influence the spatiotemporal signalling of Ras. 1 Correspondence may be addressed to either of these authors (email iprior@liverpool.ac.uk or henis@post.tau.ac.il ). 15 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 compartmentalization nanocluster...
Articles
Biochem Soc Trans (2012) 40 (6): 1512–1516.
Published: 21 November 2012
... should be addressed (email monica.abrudan@postgrad.manchester.ac.uk ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin biodiversity evolution quorum sensing signalling A recent study of the microbiomes of 242 healthy individuals found 1221 bacterial species living...
Articles
Biochem Soc Trans (2012) 40 (2): 311–323.
Published: 21 March 2012
...Alena Krejčí There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription. Central metabolic pathways are under the control of signalling pathways and, vice versa, the cellular metabolic profile influences cell signalling through...
Articles
Biochem Soc Trans (2012) 40 (1): 257–261.
Published: 19 January 2012
... subcellular locations, and the identification of a number of PtdIns5 P -binding proteins points to its involvement in a variety of key processes, including signal transduction, membrane trafficking and regulation of gene expression. Although the mechanisms that control its turnover are not yet fully...
Articles
Biochem Soc Trans (2012) 40 (1): 200–204.
Published: 19 January 2012
...Patricia Moussatche; Thomas J. Lyons The steroid hormone progesterone regulates many critical aspects of vertebrate physiology. The nuclear receptor for progesterone functions as a ligand-activated transcription factor, directly regulating gene expression. This type of signalling is referred...
Articles
Biochem Soc Trans (2012) 40 (1): 67–72.
Published: 19 January 2012
...Catherine Andreadi; Catherine Noble; Bipin Patel; Hong Jin; Maria M. Aguilar Hernandez; Kathryn Balmanno; Simon J. Cook; Catrin Pritchard The strength and duration of intracellular signalling pathway activation is a key determinant of the biological outcome of cells in response to extracellular...
Articles
Biochem Soc Trans (2011) 39 (6): 1551–1555.
Published: 21 November 2011
... the first clue for specificity of signalling in endothelial cell activation, understanding the integrative response that drives angiogenesis requires a much broader perspective. The Advances in the Cellular and Molecular Biology of Angiogenesis meeting brought together researchers at the forefront...
Articles
Biochem Soc Trans (2011) 39 (2): 431–436.
Published: 22 March 2011
..., an antibiotic and immunosuppressant, inhibits functions of TORC1. Use of this drug has revealed roles for TORC1 and its mammalian counterpart, mTORC1, in promoting many anabolic processes. mTORC1 signalling is activated by growth factors and nutrients. It is highly active in many cancers and plays a role...
Articles
Biochem Soc Trans (2011) 39 (2): 647–651.
Published: 22 March 2011
...Kathryn D. Smith; Scott A. Strobel The c-di-GMP [bis-(3′–5′)-cyclic dimeric guanosine monophosphate] riboswitch is a macromolecular target in the c-di-GMP second messenger signalling pathway. It regulates many genes related to c-di-GMP metabolism as well as genes involved in bacterial motility...
Articles
Biochem Soc Trans (2010) 38 (5): 1235–1241.
Published: 24 September 2010
...-modification cycles has been shown to bring about heterogeneous stationary patterns and travelling waves of protein activities. We review spatial patterns and modes of signal transfer through phosphorylation/dephosphorylation and GDP/GTP exchange cycles and cascades. We show how switches between low-activity...