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Articles

A multi-dimensional view of context-dependent G protein-coupled receptor function

In Collection

Awards

Maria Marti-Solano

Biochem Soc Trans (2023) 51 (1): 13–20.

DOI: https://doi.org/10.1042/BST20210650

Published: 23 January 2023

...Maria Marti-Solano G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of biomolecules to activate intracellular signalling cascades that modulate key aspects of cell physiology. Apart from their crucial role in maintaining cell homeostasis, these critical sensory...

View article titled, A multi-dimensional view of context-dependent G protein-coupled receptor function

Articles

The evolution and structure/function of bHLH–PAS transcription factor family

Hailey E. Edwards, Daniel A. Gorelick

Biochem Soc Trans (2022) 50 (3): 1227–1243.

DOI: https://doi.org/10.1042/BST20211225

Published: 13 June 2022

... 24 5 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 aryl hydrocarbon receptor bHLH–PAS transcription factors hypoxia inducible factors signalling transcription The basic helix-loop-helix Per-Arnt-Sim family...

View article titled, The evolution and structure/function of bHLH–PAS transcription factor family

Articles

Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy

In Collection

Cell death and survival

Faustino Mollinedo, Consuelo Gajate

Biochem Soc Trans (2022) 50 (3): 1105–1118.

DOI: https://doi.org/10.1042/BST20211115

Published: 19 May 2022

... interactions to signal apoptosis. Fas/CD95 death receptor-mediated apoptosis requires the formation of the so-called d eath- i nducing s ignaling c omplex (DISC), bringing together Fas/CD95, Fas-associated death domain-containing protein and procaspase-8. In the last two decades, cholesterol-rich lipid raft...

View article titled, Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy

Articles

The cellular pathways and potential therapeutics of Polycystic Kidney Disease

Taylor Richards, Kavindiya Modarage, Soniya A. Malik, Paraskevi Goggolidou

Biochem Soc Trans (2021) 49 (3): 1171–1188.

DOI: https://doi.org/10.1042/BST20200757

Published: 22 June 2021

... in PKD is due to mutations in cilia-localising genes, resulting in changes in cellular signalling. As such, compounds that are currently in preclinical and clinical trials target some of these signalling pathways that are dysregulated in PKD. In this review, we highlight these pathways including cAMP...

View article titled, The cellular pathways and potential therapeutics of Polycystic Kidney Disease

Articles

Latest update on chemokine receptors as therapeutic targets

Wing Yee Lai, Anja Mueller

Biochem Soc Trans (2021) 49 (3): 1385–1395.

DOI: https://doi.org/10.1042/BST20201114

Published: 01 June 2021

... to be considered as therapeutic targets. In the past two decades, around 45 drugs targeting chemokine receptors have been developed, yet only three are clinically approved. The challenging factors include the limited understanding of aberrant chemokine signalling in malignant diseases, high redundancy...

View article titled, Latest update on chemokine receptors as therapeutic targets

Articles

Chemogenetic approaches to dissect the role of H 2 O 2 in redox-dependent pathways using genetically encoded biosensors

Asal Ghaffari Zaki, Yusuf C. Erdoğan, Tuba Akgul Caglar, Emrah Eroglu

Biochem Soc Trans (2022) 50 (1): 335–345.

DOI: https://doi.org/10.1042/BST20210506

Published: 11 January 2021

... sciences. In recent years, the chemogenetic DAAO approach has proven beneficial to establish a new role for (patho)physiological oxidative stress on redox-dependent signaling and metabolic pathways in cultured cells and animal model systems. This mini-review covers established or emerging methods...

View article titled, Chemogenetic approaches to dissect the role of H 2 O 2 in redox-dependent pathways using genetically encoded biosensors

Articles

Effects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily

Isha Nasa, Arminja N. Kettenbach

Biochem Soc Trans (2020) 48 (5): 2015–2027.

DOI: https://doi.org/10.1042/BST20200177

Published: 14 October 2020

... by Leucine carboxyl methyltransferase-1 (LCMT1) that utilizes S-adenosyl-methionine (SAM) as the methyl donor and removed by protein phosphatase methylesterase 1 (PME1). For PP2A, methylation dictates regulatory subunit selection and thereby downstream phosphorylation signaling. Intriguingly, there are four...

View article titled, Effects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily

Articles

To be more precise: the role of intracellular trafficking in development and pattern formation

Harrison M. York, Joanne Coyle, Senthil Arumugam

Biochem Soc Trans (2020) 48 (5): 2051–2066.

DOI: https://doi.org/10.1042/BST20200223

Published: 11 September 2020

...Harrison M. York; Joanne Coyle; Senthil Arumugam Living cells interpret a variety of signals in different contexts to elucidate functional responses. While the understanding of signalling molecules, their respective receptors and response at the gene transcription level have been relatively well...

View article titled, To be more precise: the role of intracellular trafficking in development and pattern formation

Articles

Inorganic polyphosphate in mammals: where's Wally?

Yann Desfougères, Adolfo Saiardi, Cristina Azevedo

Biochem Soc Trans (2020) 48 (1): 95–101.

DOI: https://doi.org/10.1042/BST20190328

Published: 12 February 2020

... modification signalling © 2020 The Author(s) 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Open access for this article was enabled by the participation...

View article titled, Inorganic polyphosphate in mammals: where's Wally?

Articles

How is the acyl chain composition of phosphoinositides created and does it matter?

David Barneda, Sabina Cosulich, Len Stephens, Phillip Hawkins

Biochem Soc Trans (2019) 47 (5): 1291–1305.

DOI: https://doi.org/10.1042/BST20190205

Published: 28 October 2019

...David Barneda; Sabina Cosulich; Len Stephens; Phillip Hawkins The phosphoinositide (PIPn) family of signalling phospholipids are central regulators in membrane cell biology. Their varied functions are based on the phosphorylation pattern of their inositol ring, which can be recognized by selective...

View article titled, How is the acyl chain composition of phosphoinositides created and does it matter?

Articles

Swimming regulations for protein kinase A catalytic subunit

Matthew G. Gold

Biochem Soc Trans (2019) 47 (5): 1355–1366.

DOI: https://doi.org/10.1042/BST20190230

Published: 11 October 2019

... holoenzymes [ 39 ], indicative of C subunit release 2 . AlphaScreen assay: Signal indicating association of GST-RI and biotinylated C subunit reduced to background levels at high cAMP concentration [ 40 ]. In cultured cells UV cross-linking of C subunits to both RI and RII in HEK cells...

View article titled, Swimming regulations for protein kinase A catalytic subunit

Articles

Selective small-molecule EPAC activators

Urszula Luchowska-Stańska, David Morgan, Stephen J. Yarwood, Graeme Barker

Biochem Soc Trans (2019) 47 (5): 1415–1427.

DOI: https://doi.org/10.1042/BST20190254

Published: 11 October 2019

...Urszula Luchowska-Stańska; David Morgan; Stephen J. Yarwood; Graeme Barker The cellular signalling enzymes, EPAC1 and EPAC2, have emerged as key intracellular sensors of the secondary messenger cyclic 3′,5′-adenosine monophosphate (cyclic adenosine monophosphate) alongside protein kinase...

View article titled, Selective small-molecule EPAC activators

Articles

The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall

Lilian Schimmel, Emma Gordon

Biochem Soc Trans (2018) 46 (6): 1673–1680.

DOI: https://doi.org/10.1042/BST20180377

Published: 04 December 2018

...Lilian Schimmel; Emma Gordon Endothelial cell–cell adhesion within the wall of the vasculature controls a range of physiological processes, such as growth, integrity and barrier function. The adhesive properties of endothelial cells are tightly controlled by a complex cascade of signals transmitted...

View article titled, The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall

Articles

PARPs in genome stability and signal transduction: implications for cancer therapy

Luca Palazzo, Ivan Ahel

Biochem Soc Trans (2018) 46 (6): 1681–1695.

DOI: https://doi.org/10.1042/BST20180418

Published: 12 November 2018

... on target proteins or in the form of ADP-ribose chains, with the latter called poly(ADP-ribosyl)ation. PARPs regulate many cellular processes, including the maintenance of genome stability and signal transduction. In this review, we focus on the PARP family members that possess the ability to modify...

View article titled, PARPs in genome stability and signal transduction: implications for cancer therapy

Articles

RAS variant signalling

Stephanie P. Mo, Judy M. Coulson, Ian A. Prior

Biochem Soc Trans (2018) 46 (5): 1325–1332.

DOI: https://doi.org/10.1042/BST20180173

Published: 04 October 2018

...Stephanie P. Mo; Judy M. Coulson; Ian A. Prior RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent...

View article titled, RAS variant signalling

Articles

The Golgi architecture and cell sensing

Christian Makhoul, Prajakta Gosavi, Paul A. Gleeson

Biochem Soc Trans (2018) 46 (5): 1063–1072.

DOI: https://doi.org/10.1042/BST20180323

Published: 21 September 2018

...Christian Makhoul; Prajakta Gosavi; Paul A. Gleeson An array of signalling molecules are located at the Golgi apparatus, including phosphoinositides, small GTPases, kinases, and phosphatases, which are linked to multiple signalling pathways. Initially considered to be associated predominantly...

View article titled, The Golgi architecture and cell sensing

Articles

Logic-gated approaches to extend the utility of chimeric antigen receptor T-cell technology

Lisa M. Ebert, Wenbo Yu, Tessa Gargett, Michael P. Brown

Biochem Soc Trans (2018) 46 (2): 391–401.

DOI: https://doi.org/10.1042/BST20170178

Published: 14 March 2018

... specificities recognised by CAR-T cells will broaden tumour antigen coverage, potentially overcoming tumour heterogeneity and limiting tumour antigen escape. Tuning the balance of signalling within bi-specific CAR-T cells may enable tumour targeting while sparing normal tissues, and thus minimise on-target, off...

View article titled, Logic-gated approaches to extend the utility of chimeric antigen receptor T-cell technology

Articles

Pseudo-DUBs as allosteric activators and molecular scaffolds of protein complexes

Miriam Walden, Safi Kani Masandi, Krzysztof Pawłowski, Elton Zeqiraj

Biochem Soc Trans (2018) 46 (2): 453–466.

DOI: https://doi.org/10.1042/BST20160268

Published: 22 February 2018

...Miriam Walden; Safi Kani Masandi; Krzysztof Pawłowski; Elton Zeqiraj The ubiquitin (Ub) proteasome system and Ub signalling networks are crucial to cell biology and disease development. Deubiquitylases (DUBs) control cell signalling by removing mono-Ub and polyubiquitin chains from substrates. DUBs...

View article titled, Pseudo-DUBs as allosteric activators and molecular scaffolds of protein complexes

Includes: Supplementary data

Articles

Mass spectrometry techniques for studying the ubiquitin system

Rachel E. Heap, Megan S. Gant, Frederic Lamoliatte, Julien Peltier, Matthias Trost

Biochem Soc Trans (2017) 45 (5): 1137–1148.

DOI: https://doi.org/10.1042/BST20170091

Published: 22 September 2017

... of the Biochemical Society 2017 deubiquitylase mass spectrometry proteomics signalling SUMOylation ubiquitins Ubiquitylation is a post-translational modification involving the covalent binding of the small, highly conserved protein ubiquitin, consisting of 76 amino acids, to a target substrate...

View article titled, Mass spectrometry techniques for studying the ubiquitin system

Articles

The secret life of kinases: insights into non-catalytic signalling functions from pseudokinases

Annette V. Jacobsen, James M. Murphy

Biochem Soc Trans (2017) 45 (3): 665–681.

DOI: https://doi.org/10.1042/BST20160331

Published: 15 June 2017

...Annette V. Jacobsen; James M. Murphy Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise ∼10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies...

View article titled, The secret life of kinases: insights into non-catalytic signalling functions from pseudokinases

Articles

Phosphoinositide signalling in type 2 diabetes: a β-cell perspective

Lucia E. Rameh, Jude T. Deeney

Biochem Soc Trans (2016) 44 (1): 293–298.

DOI: https://doi.org/10.1042/BST20150229

Published: 09 February 2016

...-established and potential new roles for phosphoinositides in β-cell function/dysfunction and discuss how our knowledge of phosphoinositide signalling could aid in the identification of potential strategies for treating or preventing type 2 diabetes. 1 To whom correspondence should be addressed (email...

View article titled, Phosphoinositide signalling in type 2 diabetes: a β-cell perspective

Articles

The new world of inorganic polyphosphates

Cristina Azevedo, Adolfo Saiardi

Biochem Soc Trans (2016) 44 (1): 13–17.

DOI: https://doi.org/10.1042/BST20150210

Published: 09 February 2016

... conditions. Polyphosphorylation detection was only possible through extensive biochemical characterization. Two targets have been identified: nuclear signal recognition 1 (Nsr1) and its interacting partner, topoisomerase 1 (Top1). Polyphosphorylation occurs within a conserved N-terminal p oly a cidic serine...

View article titled, The new world of inorganic polyphosphates

Articles

Tribbles and arthritis: what are the links?

Andrew D. Rowan, Gary J. Litherland

Biochem Soc Trans (2015) 43 (5): 1051–1056.

DOI: https://doi.org/10.1042/BST20150076

Published: 09 October 2015

...Andrew D. Rowan; Gary J. Litherland The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction...

View article titled, Tribbles and arthritis: what are the links?

Articles

Tribbles at the cross-roads…

Endre Kiss-Toth, Guillermo Velasco, Warren S. Pear

Biochem Soc Trans (2015) 43 (5): 1049–1050.

DOI: https://doi.org/10.1042/BST20150122

Published: 09 October 2015

...Endre Kiss-Toth; Guillermo Velasco; Warren S. Pear 1 To whom correspondence should be addressed (email e.kiss-toth@sheffield.ac.uk ) . 2 6 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer lipids metabolism signalling tribbles ubiquitin...

View article titled, Tribbles at the cross-roads…

Articles

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

Maria A. O’Connell, John D. Hayes

Biochem Soc Trans (2015) 43 (4): 687–689.

DOI: https://doi.org/10.1042/BST20150069

Published: 03 August 2015

... physiological and pathological processes has become widely recognized; these include redox signalling and redox homoeostasis, drug metabolism and disposition, intermediary metabolism, cellular adaptation to stress, chemoprevention and chemoresistance, toxicity, inflammation, neurodegeneration, lipogenesis...

View article titled, The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

Articles

SEC16 in COPII coat dynamics at ER exit sites

Joep Sprangers, Catherine Rabouille

Biochem Soc Trans (2015) 43 (1): 97–103.

DOI: https://doi.org/10.1042/BST20140283

Published: 26 January 2015

... to nutrient signalling, thus coupling environmental stimuli to secretory capacity. 1 To whom correspondence should be addressed (email c.rabouille@hubrecht.eu ) . 10 11 2014 To understand how Sec16 carries out its function in COPII coat dynamics, domains are being mapped. Three domains...

View article titled, SEC16 in COPII coat dynamics at ER exit sites

Articles

Functional impact of glycogen degradation on astrocytic signalling

Margit S. Müller

Biochem Soc Trans (2014) 42 (5): 1311–1315.

DOI: https://doi.org/10.1042/BST20140157

Published: 18 September 2014

..., the signalling pathways eliciting glycogen degradation inside astrocytes are themselves energy-demanding processes, a fact that has been emphasized in recent studies, demonstrating dependence of these signalling mechanisms on glycogenolytic ATP. 1 email mm889@cam.ac.uk 9 6 2014 © 2014...

View article titled, Functional impact of glycogen degradation on astrocytic signalling

Articles

Signalling specificity in the Akt pathway in breast cancer

Abbe R. Clark, Alex Toker

Biochem Soc Trans (2014) 42 (5): 1349–1355.

DOI: https://doi.org/10.1042/BST20140160

Published: 18 September 2014

...-kinase (PI3K)/Akt signalling cascade. Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell survival, growth, proliferation and metabolism. Strikingly, non-redundant and even opposing functions of Akt isoforms in the regulation of phenotypes associated...

View article titled, Signalling specificity in the Akt pathway in breast cancer

Articles

Application of redox proteomics to skeletal muscle aging and exercise

Brian McDonagh, Giorgos K. Sakellariou, Malcolm J. Jackson

Biochem Soc Trans (2014) 42 (4): 965–970.

DOI: https://doi.org/10.1042/BST20140085

Published: 11 August 2014

... (reactive nitrogen species) necessary for the regulation of many proteins involved in excitation–contraction coupling. The magnitude and species of ROS/RNS generated by contracting muscles will have downstream effects on specific protein targets and cellular redox signalling. Redox modifications on specific...

View article titled, Application of redox proteomics to skeletal muscle aging and exercise

Articles

ROS signalling, NADPH oxidases and cancer

William D. Landry, Thomas G. Cotter

Biochem Soc Trans (2014) 42 (4): 934–938.

DOI: https://doi.org/10.1042/BST20140060

Published: 11 August 2014

... with such signalling properties, and this molecule has been shown to affect a wide range of cellular functions. Its localized synthesis by the Nox (NADPH oxidase) family of enzymes and how these enzymes are regulated is of particular interest to those who work in the field of tumour biology. 1 To whom...

View article titled, ROS signalling, NADPH oxidases and cancer

Articles

Anticipating mechanisms of resistance to PI3K inhibition in breast cancer: a challenge in the era of precision medicine

Cedric Leroy, Romain J. Amante, Mohamed Bentires-Alj

Biochem Soc Trans (2014) 42 (4): 733–741.

DOI: https://doi.org/10.1042/BST20140034

Published: 11 August 2014

... be the result of genomic alterations such as PIK3CA mutation, PTEN (phosphatase and tensin homologue deleted on chromosome 10) loss or the activation of upstream protein tyrosine kinases. Not surprisingly, the PI3K signalling pathway has become an attractive therapeutic target, and numerous inhibitors...

View article titled, Anticipating mechanisms of resistance to PI3K inhibition in breast cancer: a challenge in the era of precision medicine

Articles

Vertebrate pheromones and other semiochemicals: the potential for accommodating complexity in signalling by volatile compounds for vertebrate management

John A. Pickett, Stephen Barasa, Michael A. Birkett

Biochem Soc Trans (2014) 42 (4): 846–850.

DOI: https://doi.org/10.1042/BST20140134

Published: 11 August 2014

...John A. Pickett; Stephen Barasa; Michael A. Birkett The interaction between volatile and non-volatile, e.g. proteinaceous, components of pheromone and other semiochemical-based signalling systems presents a daunting set of problems for exploitation in the management of vertebrates, good or bad...

View article titled, Vertebrate pheromones and other semiochemicals: the potential for accommodating complexity in signalling by volatile compounds for vertebrate management

Articles

Using embryonic stem cells to understand how glycosaminoglycans regulate differentiation

Rebecca J. Holley, Kate A. Meade, Catherine L.R. Merry

Biochem Soc Trans (2014) 42 (3): 689–695.

DOI: https://doi.org/10.1042/BST20140064

Published: 22 May 2014

...Rebecca J. Holley; Kate A. Meade; Catherine L.R. Merry Differentiation and subsequent specialization of every cell within an organism is an intricate interwoven process. A complex network of signalling pathways eventually leads to the specification of a multitude of different cell types able...

View article titled, Using embryonic stem cells to understand how glycosaminoglycans regulate differentiation

Articles

cAMP signalling meets mitochondrial compartments

Konstantinos Lefkimmiatis

Biochem Soc Trans (2014) 42 (2): 265–269.

DOI: https://doi.org/10.1042/BST20130281

Published: 20 March 2014

... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling Mitochondria are marvels of compartmentalization, and this property is intimately connected with their function. Compartmentalization of these organelles is achieved thanks to two structures...

View article titled, cAMP signalling meets mitochondrial compartments

Articles

Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR

Stephen Boulton, Madoka Akimoto, Bryan VanSchouwen, Kody Moleschi, Rajeevan Selvaratnam, Rajanish Giri, Giuseppe Melacini

Biochem Soc Trans (2014) 42 (2): 302–307.

DOI: https://doi.org/10.1042/BST20130282

Published: 20 March 2014

...-dependent signalling pathways has a high translational potential. However, the ubiquity of eukaryotic CBDs also poses a challenge in terms of selectivity. Before the full translational potential of cAMP signalling can be tapped, it is critical to understand the structural basis for selective cAMP agonism...

View article titled, Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR

Articles

Autophagy and mammalian development

Xiaoting Wu, Hyeran Won, David C. Rubinsztein

Biochem Soc Trans (2013) 41 (6): 1489–1494.

DOI: https://doi.org/10.1042/BST20130185

Published: 20 November 2013

... To whom correspondence should be addressed (email dcr1000@hermes.cam.ac.uk ). 5 8 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 TGFβ signalling is one of the most important players that drives developmental programmes that control cell behaviour, and plays...

View article titled, Autophagy and mammalian development

Articles

On mTOR nomenclature

Michael N. Hall

Biochem Soc Trans (2013) 41 (4): 887–888.

DOI: https://doi.org/10.1042/BST20130092

Published: 18 July 2013

...@unibas.ch 29 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cell growth mammalian target of rapamycin (mTOR) nomenclature rapamycin regulatory associated protein of mammalian target of rapamycin (raptor) signalling The highly conserved TOR (target...

View article titled, On mTOR nomenclature

Articles

ILK: a pseudokinase with a unique function in the integrin–actin linkage

Sushmita Ghatak, Jessica Morgner, Sara A. Wickström

Biochem Soc Trans (2013) 41 (4): 995–1001.

DOI: https://doi.org/10.1042/BST20130062

Published: 18 July 2013

... extracellular matrix integrin-linked kinase (ILK) pseudokinase signalling In order to establish and maintain structural organization and proper function of the tissue, cells need to sense and process extracellular signals. These signals comprise soluble factors such as growth factors and chemokines...

View article titled, ILK: a pseudokinase with a unique function in the integrin–actin linkage

Articles

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

Elaine A. Dunlop, Andrew R. Tee

Biochem Soc Trans (2013) 41 (4): 939–943.

DOI: https://doi.org/10.1042/BST20130030

Published: 18 July 2013

... translation. In order for cells to control cellular homoeostasis during growth, there is close signalling interplay between mTORC1 and two other protein kinases, AMPK (AMP-activated protein kinase) and ULK1 (Unc-51-like kinase 1). This kinase triad collectively senses the energy and nutrient status...

View article titled, The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

Articles

New insights into the structure and function of the pseudokinase domain in JAK2

Olli Silvennoinen, Daniela Ungureanu, Yashavanthi Niranjan, Henrik Hammaren, Rajintha Bandaranayake, Stevan R. Hubbard

Biochem Soc Trans (2013) 41 (4): 1002–1007.

DOI: https://doi.org/10.1042/BST20130005

Published: 18 July 2013

...Olli Silvennoinen; Daniela Ungureanu; Yashavanthi Niranjan; Henrik Hammaren; Rajintha Bandaranayake; Stevan R. Hubbard JAK (Janus kinase) 2 plays a critical role in signal transduction through several cytokine receptors. JAKs contain a typical tyrosine kinase domain preceded by a pseudokinase [JH2...

View article titled, New insights into the structure and function of the pseudokinase domain in JAK2

Articles

How ligands and signalling proteins affect G-protein-coupled receptors' conformational landscape

Sophie Mary, Jean-Alain Fehrentz, Marjorie Damian, Pascal Verdié, Jean Martinez, Jacky Marie, Jean-Louis Banères

Biochem Soc Trans (2013) 41 (1): 144–147.

DOI: https://doi.org/10.1042/BST20120267

Published: 29 January 2013

...Sophie Mary; Jean-Alain Fehrentz; Marjorie Damian; Pascal Verdié; Jean Martinez; Jacky Marie; Jean-Louis Banères The dynamic character of GPCRs (G-protein-coupled receptors) is essential to their function. However, the details of how ligands and signalling proteins stabilize a receptor conformation...

View article titled, How ligands and signalling proteins affect G-protein-coupled receptors' conformational landscape

Articles

The role of palmitoylation in regulating Ras localization and function

Sharon Eisenberg, Alex J. Laude, Alison J. Beckett, Craig J. Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I. Henis, Ian A. Prior

Biochem Soc Trans (2013) 41 (1): 79–83.

DOI: https://doi.org/10.1042/BST20120268

Published: 29 January 2013

... to influence the spatiotemporal signalling of Ras. 1 Correspondence may be addressed to either of these authors (email iprior@liverpool.ac.uk or henis@post.tau.ac.il ). 15 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 compartmentalization nanocluster...

View article titled, The role of palmitoylation in regulating Ras localization and function

Articles

Killing as means of promoting biodiversity

Monica I. Abrudan, Sarah Brown, Daniel E. Rozen

Biochem Soc Trans (2012) 40 (6): 1512–1516.

DOI: https://doi.org/10.1042/BST20120196

Published: 21 November 2012

... To whom correspondence should be addressed (email monica.abrudan@postgrad.manchester.ac.uk ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin biodiversity evolution quorum sensing signalling A recent study of the microbiomes of 242 healthy individuals found 1221...

View article titled, Killing as means of promoting biodiversity

Articles

Metabolic sensors and their interplay with cell signalling and transcription

Alena Krejčí

Biochem Soc Trans (2012) 40 (2): 311–323.

DOI: https://doi.org/10.1042/BST20110767

Published: 21 March 2012

...Alena Krejčí There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription. Central metabolic pathways are under the control of signalling pathways and, vice versa, the cellular metabolic profile influences cell signalling through...

View article titled, Metabolic sensors and their interplay with cell signalling and transcription

Articles

The emerging role of PtdIns5 P : another signalling phosphoinositide takes its place

Deborah L. Grainger, Christodoulos Tavelis, Alexander J. Ryan, Katherine A. Hinchliffe

Biochem Soc Trans (2012) 40 (1): 257–261.

DOI: https://doi.org/10.1042/BST20110617

Published: 19 January 2012

... subcellular locations, and the identification of a number of PtdIns5 P -binding proteins points to its involvement in a variety of key processes, including signal transduction, membrane trafficking and regulation of gene expression. Although the mechanisms that control its turnover are not yet fully...

View article titled, The emerging role of PtdIns5 P : another signalling phosphoinositide takes its place

Articles

Regulation of MEK/ERK pathway output by subcellular localization of B-Raf

Catherine Andreadi, Catherine Noble, Bipin Patel, Hong Jin, Maria M. Aguilar Hernandez, Kathryn Balmanno, Simon J. Cook, Catrin Pritchard

Biochem Soc Trans (2012) 40 (1): 67–72.

DOI: https://doi.org/10.1042/BST20110621

Published: 19 January 2012

...Catherine Andreadi; Catherine Noble; Bipin Patel; Hong Jin; Maria M. Aguilar Hernandez; Kathryn Balmanno; Simon J. Cook; Catrin Pritchard The strength and duration of intracellular signalling pathway activation is a key determinant of the biological outcome of cells in response to extracellular...

View article titled, Regulation of MEK/ERK pathway output by subcellular localization of B-Raf

Articles

Non-genomic progesterone signalling and its non-canonical receptor

Patricia Moussatche, Thomas J. Lyons

Biochem Soc Trans (2012) 40 (1): 200–204.

DOI: https://doi.org/10.1042/BST20110638

Published: 19 January 2012

...Patricia Moussatche; Thomas J. Lyons The steroid hormone progesterone regulates many critical aspects of vertebrate physiology. The nuclear receptor for progesterone functions as a ligand-activated transcription factor, directly regulating gene expression. This type of signalling is referred...

View article titled, Non-genomic progesterone signalling and its non-canonical receptor

Articles

Advances in the Cellular and Molecular Biology of Angiogenesis

Stuart Egginton, Roy Bicknell

Biochem Soc Trans (2011) 39 (6): 1551–1555.

DOI: https://doi.org/10.1042/BST20110749

Published: 21 November 2011

... the first clue for specificity of signalling in endothelial cell activation, understanding the integrative response that drives angiogenesis requires a much broader perspective. The Advances in the Cellular and Molecular Biology of Angiogenesis meeting brought together researchers at the forefront...

View article titled, Advances in the Cellular and Molecular Biology of Angiogenesis

Articles

mTOR Signalling in Health and Disease

Christopher G. Proud

Biochem Soc Trans (2011) 39 (2): 431–436.

DOI: https://doi.org/10.1042/BST0390431

Published: 22 March 2011

..., an antibiotic and immunosuppressant, inhibits functions of TORC1. Use of this drug has revealed roles for TORC1 and its mammalian counterpart, mTORC1, in promoting many anabolic processes. mTORC1 signalling is activated by growth factors and nutrients. It is highly active in many cancers and plays a role...

View article titled, mTOR Signalling in Health and Disease

Articles

Interactions of the c-di-GMP riboswitch with its second messenger ligand

Kathryn D. Smith, Scott A. Strobel

Biochem Soc Trans (2011) 39 (2): 647–651.

DOI: https://doi.org/10.1042/BST0390647

Published: 22 March 2011

...Kathryn D. Smith; Scott A. Strobel The c-di-GMP [bis-(3′–5′)-cyclic dimeric guanosine monophosphate] riboswitch is a macromolecular target in the c-di-GMP second messenger signalling pathway. It regulates many genes related to c-di-GMP metabolism as well as genes involved in bacterial motility...

View article titled, Interactions of the c-di-GMP riboswitch with its second messenger ligand

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