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Keywords: signaling
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Biochem Soc Trans (2024) BST20211241.
Published: 04 January 2024
...Mubashir Mintoo; Vinodh Rajagopalan; John P. O'Bryan Intersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions including regulation of endocytosis, vesicle transport, and activation of various signal transduction pathways. There are two ITSN genes located...
Biochem Soc Trans (2023) 51 (5): 1765–1776.
Published: 22 September 2023
...Kai Zhang; Victoria Chan; Roberto J. Botelho; Costin N. Antonescu Cardiolipin and phosphatidylinositol along with the latter's phosphorylated derivative phosphoinositides, control a wide range of cellular functions from signal transduction, membrane traffic, mitochondrial function, cytoskeletal...
Biochem Soc Trans (2023) 51 (4): 1585–1595.
Published: 11 July 2023
... and the Biochemical Society under a transformative agreement with Individual. biosensors chemical biology fluorescence microscopy fluorescent proteins protein engineering signaling The 1994 demonstration that the green fluorescent protein (GFP) could be recombinantly and functionally expressed...
Biochem Soc Trans (2023) 51 (4): 1419–1427.
Published: 06 July 2023
... 2023 poxvirus protein phosphatases signaling Phosphorylation, a reversible post-translational protein modification regulating important cellular functions, is mediated by complementary enzymes, protein kinases and phosphatases. Protein phosphatases can be grouped into two major...
Biochem Soc Trans (2023) 51 (3): 1083–1096.
Published: 19 June 2023
... of their potential roles in development and disease, including vascular diseases, inflammation and various cancers. Recent structural data is providing important insights into their functions, which are complex, involving both intrinsic signaling through cytoplasmic binding partners and co-operative mechanisms where...
Biochem Soc Trans (2023) 51 (2): 655–664.
Published: 16 March 2023
... signaling to mTORC1 through the Rag GTPases. Cellular arginine sensor for mTORC1 (CASTOR1) in parallel with SLC38A9 regulates arginine sensing to positively regulate mTORC1. CASTOR1 can exist as a homodimer or heterodimer with CASTOR2. When arginine is limiting CASTOR1 binds to and inhibits GATOR2...
Biochem Soc Trans (2022) 50 (6): 1859–1873.
Published: 18 November 2022
...Adrián F. Alvarez; Dimitris Georgellis Two-component systems (TCSs) are modular signaling circuits that regulate diverse aspects of microbial physiology in response to environmental cues. These molecular circuits comprise a sensor histidine kinase (HK) protein that contains a conserved histidine...
Biochem Soc Trans (2022) 50 (5): 1353–1364.
Published: 25 October 2022
... 3B ). Although rather speculative, an exciting possibility arises that these TM type III effectors position the sensory SAVED domain on the outside of the cell, hinting at intercellular signaling. Signaling the presence of infection to others in the population can be seen in other CRISPR–Cas systems...
Biochem Soc Trans (2021) 49 (5): 2123–2131.
Published: 08 September 2021
... and the functions of the dynamics in the regulation of p53-dependent cell stress responses. We also compare dynamic encoding in the p53 system with that found in other important cell signaling systems, many of which can interact with the p53 network. Finally, we highlight some of the current challenges...
Biochem Soc Trans (2021) 49 (1): 41–54.
Published: 05 February 2021
... that integrates metabolic signals and adapts cellular metabolism and functions to nutritional changes and stress. Feedforward and feedback loops, crosstalks and a plethora of modulators finely balance MTOR-driven anabolic and catabolic processes. This complexity renders it difficult — if not impossible...
Biochem Soc Trans (2020) 48 (3): 1167–1176.
Published: 05 May 2020
... of individual PDGFRs upon activation, revealing the importance of the whole receptor in the propagation of extracellular ligand binding and dimerization. Furthermore, we review ongoing research demonstrating the significance of receptor internalization and signal attenuation in the regulation of PDGFR activity...
Biochem Soc Trans (2020) 48 (1): 179–185.
Published: 12 February 2020
... (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In this review we discussed the role that signals downstream of ITK, including the Ras/MAPK pathway, play in differentially controlling the differentiation of T H 17, Foxp3 + T...
Biochem Soc Trans (2019) 47 (5): 1543–1555.
Published: 11 October 2019
...Maurizio Mongiat; Simone Buraschi; Eva Andreuzzi; Thomas Neill; Renato V. Iozzo The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific...
Biochem Soc Trans (2019) 47 (1): 13–22.
Published: 17 December 2018
... interactions with GEFs, GAPs and effectors through colocalization and positional matching. Furthermore, it leads to small GTPase nanoclustering and to lipid demixing, which drives the assembly of molecular platforms in which proteins and lipids co-operate in producing high-fidelity signals through feedback...
Biochem Soc Trans (2018) 46 (3): 683–690.
Published: 21 May 2018
... GTPases signaling TBC1D1 TBC1D4 Rab (Ras-related proteins in brain) GTPases comprise the largest family within the monomeric 27 kDa Ras-like G protein superfamily [ 1 – 5 ]. Rab proteins cycle between active GTP-bound ‘on' and inactive GDP-bound ‘off' conformational states [ 5 , 6...
Biochem Soc Trans (2017) 45 (1): 79–88.
Published: 15 February 2017
...Galina Semenova; Jonathan Chernoff p21-Activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its tractability as a target for small...
Biochem Soc Trans (2016) 44 (2): 419–424.
Published: 11 April 2016
... in eukaryotes and have been implicated in different cellular processes, including vesicular trafficking, signal transduction, and lipid metabolism. Recent studies suggest that PITPs function at membrane contact sites (MCSs) to facilitate the transport of PI from its synthesis site at the endoplasmic reticulum...