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Biochem Soc Trans (2022) 50 (6): 1859–1873.
Published: 18 November 2022
...Adrián F. Alvarez; Dimitris Georgellis Two-component systems (TCSs) are modular signaling circuits that regulate diverse aspects of microbial physiology in response to environmental cues. These molecular circuits comprise a sensor histidine kinase (HK) protein that contains a conserved histidine...
Biochem Soc Trans (2022) 50 (5): 1353–1364.
Published: 25 October 2022
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . abortive infection antiviral defense cOA CRISPR nuclease signaling CRISPR–Cas is an adaptive immune system in prokaryotes that provides sequence...
Biochem Soc Trans (2021) 49 (5): 2123–2131.
Published: 08 September 2021
... and the functions of the dynamics in the regulation of p53-dependent cell stress responses. We also compare dynamic encoding in the p53 system with that found in other important cell signaling systems, many of which can interact with the p53 network. Finally, we highlight some of the current challenges...
Biochem Soc Trans (2021) 49 (1): 41–54.
Published: 05 February 2021
... that integrates metabolic signals and adapts cellular metabolism and functions to nutritional changes and stress. Feedforward and feedback loops, crosstalks and a plethora of modulators finely balance MTOR-driven anabolic and catabolic processes. This complexity renders it difficult — if not impossible...
Biochem Soc Trans (2020) 48 (3): 1167–1176.
Published: 05 May 2020
... of individual PDGFRs upon activation, revealing the importance of the whole receptor in the propagation of extracellular ligand binding and dimerization. Furthermore, we review ongoing research demonstrating the significance of receptor internalization and signal attenuation in the regulation of PDGFR activity...
Biochem Soc Trans (2020) 48 (1): 179–185.
Published: 12 February 2020
... (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In this review we discussed the role that signals downstream of ITK, including the Ras/MAPK pathway, play in differentially controlling the differentiation of T H 17, Foxp3 + T...
Biochem Soc Trans (2019) 47 (5): 1543–1555.
Published: 11 October 2019
...Maurizio Mongiat; Simone Buraschi; Eva Andreuzzi; Thomas Neill; Renato V. Iozzo The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific...
Biochem Soc Trans (2019) 47 (1): 13–22.
Published: 17 December 2018
... interactions with GEFs, GAPs and effectors through colocalization and positional matching. Furthermore, it leads to small GTPase nanoclustering and to lipid demixing, which drives the assembly of molecular platforms in which proteins and lipids co-operate in producing high-fidelity signals through feedback...
In CollectionCelebrating 100 years of insulin research
Biochem Soc Trans (2018) 46 (3): 683–690.
Published: 21 May 2018
... of the Biochemical Society 2018 Rab GTPases signaling TBC1D1 TBC1D4 Rab (Ras-related proteins in brain) GTPases comprise the largest family within the monomeric 27 kDa Ras-like G protein superfamily [ 1 – 5 ]. Rab proteins cycle between active GTP-bound ‘on' and inactive GDP-bound ‘off...
Biochem Soc Trans (2018) 46 (2): 351–360.
Published: 09 March 2018
... (Protor-1) [ 89 – 94 ]. mTOR can modulate diabetes [ 24 , 32 , 66 , 95 – 97 ], neurodegenerative disorders [ 2 , 31 , 36 , 66 , 67 , 98 – 101 ], and dementia [ 11 , 15 , 17 , 102 ]. mTOR has a significant role in the modulation of autophagy induction [ 103 ]. Important in the signaling cascade of mTOR...
Biochem Soc Trans (2017) 45 (6): 1253–1261.
Published: 20 October 2017
... structure prediction toward accuracies approaching the experimental resolution limit. Going beyond structure prediction, the same mathematical framework allows mimicking evolutionary fitness landscapes to infer signaling interactions, epistasis, or mutational landscapes. Correspondence: Alexander...
Biochem Soc Trans (2017) 45 (1): 79–88.
Published: 15 February 2017
...Galina Semenova; Jonathan Chernoff p21-Activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its tractability as a target for small...
Biochem Soc Trans (2016) 44 (2): 419–424.
Published: 11 April 2016
... in eukaryotes and have been implicated in different cellular processes, including vesicular trafficking, signal transduction, and lipid metabolism. Recent studies suggest that PITPs function at membrane contact sites (MCSs) to facilitate the transport of PI from its synthesis site at the endoplasmic reticulum...