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Keywords: signal transduction
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Articles
Biochem Soc Trans (2021) 49 (4): 1695–1709.
Published: 20 July 2021
.... adhesion receptors agonists G-protein-coupled receptors G-proteins signal transduction Correspondence: Graham Ladds ( grl30@cam.ac.uk ) * These authors contributed equally to this work. 24 5 2021 17 6 2021 18 6 2021 © 2021 The Author(s) 2021 This is an open...
Articles
Biochem Soc Trans (2021) 49 (2): 675–683.
Published: 16 April 2021
...). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer dimerization hippo pathway protein kinases SARAH domain signal transduction The Hippo pathway was originally discovered in Drosophila from genetic screens designed to identify pathways the regulate...
Articles
Biochem Soc Trans (2020) 48 (2): 441–449.
Published: 22 April 2020
... and lipidation of other proteins. Examples include the kinases Akt1, CDK5 and GSK3β, the phosphatases calcineurin, PP2A and PHLPP, and the ubiquitin E3-ligase SKP2. The impact of FKBP51 on PTMs of signal transduction proteins significantly extends the functional versatility of this protein. As a stress-induced...
Articles
Biochem Soc Trans (2017) 45 (1): 237–249.
Published: 15 February 2017
... modifications, and interactions. The cell co-ordinates these molecular events, on thousands of cellular proteins, in concert with environmental and physiological cues to fine-tune epigenetics, transcription, translation, signal transduction, cell cycle, and metabolism. The cellular stress response...
Articles
Biochem Soc Trans (2017) 45 (1): 51–64.
Published: 15 February 2017
... on behalf of the Biochemical Society 2017 cancer growth factor microRNA non-coding RNA signal transduction While studying chemical carcinogenesis in the 1940s and examining the somatic mutation theory of cancer, Berenblum and Shubik [ 1 ] proposed a three-stage model of cancer development...
Articles
Biochem Soc Trans (2017) 45 (1): 37–49.
Published: 15 February 2017
... transport (IFT) machinery [ 36 , 37 ], exact details of the disassembly mechanism remain to be elucidated. AURKA cilia ciliopathy human malignancy protein–serine–threonine kinases signal transduction More than 20 years ago, a serine/threonine kinase required for correct spindle formation...
Articles
Biochem Soc Trans (2016) 44 (5): 1441–1454.
Published: 19 October 2016
...; Tregs, regulatory T-cells; MDSCs, myeloid-derived suppressor cells; NK cells, natural killer cells; DCs, dendritic cells. cancer immunotherapy signal transduction transforming growth factor-β tumor biology The stroma in the tumor microenvironment consists of many cells...
Articles
Biochem Soc Trans (2016) 44 (4): 1135–1141.
Published: 15 August 2016
...). published by Portland Press Limited on behalf of the Biochemical Society 2016 activin receptor-like kinase 1 (ALK1) bone morphogenetic protein 9 (BMP9) bone morphogenetic protein 10 (BMP10) BMP receptor type II (BMPR-II) endothelial cell signal transduction The endothelial bone...
Articles
Biochem Soc Trans (2016) 44 (2): 452–459.
Published: 11 April 2016
...) signal transduction The endoplasmic reticulum (ER) is the major cellular Ca 2+ store that utilizes its Ca 2+ content to achieve a variety of signalling outcomes. The ER is therefore critical to the role of Ca 2+ as a cytosolic second messenger that controls muscle contraction, protein...
Articles
Biochem Soc Trans (2016) 44 (1): 273–278.
Published: 09 February 2016
... [ 25 – 27 ]. However, the consequences of PTEN association with PI3P rich vesicles associated with microtubules may be very significant, both in terms of where PTEN acts on its substrate(s) and from a regulatory point of view. AKT cancer phosphatase phosphoinositide 3-kinase signal...
Articles
Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
... 2016 inhibitor O-linked N -acetylglucosamine (O-GlcNAc) O-linked N -acetylglucosamine (O-GlcNAc) transferase post-translational modification protein structure signal transduction Protein O-linked N -acetylglucosamine (O-GlcNAc) post-translational modification is characterized...
Articles
Biochem Soc Trans (2014) 42 (6): 1538–1542.
Published: 17 November 2014
... © 2014 Biochemical Society 2014 calcium signalling confocal microscopy fluorescent protein fluorescence resonance energy transfer sensor (FRET sensor) lipid signalling signal transduction Owing to the highly conserved kinase domain of PKCs [ 7 ], in general, the specificity...
Articles
Biochem Soc Trans (2014) 42 (6): 1484–1489.
Published: 17 November 2014
...Pulak R. Nath; Noah Isakov Protein kinase Cθ (PKCθ) is a key enzyme in T-lymphocytes where it plays an important role in signal transduction downstream of the activated T-cell receptor (TCR) and the CD28 co-stimulatory receptor. Antigenic stimulation of T-cells triggers PKCθ translocation...
Articles
Biochem Soc Trans (2014) 42 (6): 1584–1589.
Published: 17 November 2014
... m.j.cross@liv.ac.uk ). 13 10 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis big MAPK1 (BMK1) endothelial cell extracellular-signal-regulated kinase 5 (ERK5) mitogen-activated protein kinase (MAPK) signal transduction Mitogen-activated...
Articles
Biochem Soc Trans (2014) 42 (6): 1773–1779.
Published: 17 November 2014
... be addressed (email helen.irving@monash.edu ). 12 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 guanylate cyclase interleukin receptor-associated kinase 3 (IRAK3) kinase phytosulfokine receptor 1 (PSKR1) signal transduction cGMP is a key signalling...
Articles
Biochem Soc Trans (2014) 42 (6): 1506–1511.
Published: 17 November 2014
.... 1 email husem@mskcc.org 17 7 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 actin cell polarity microtubule protein kinase C (PKC) signal transduction T-cell T-cell receptor (TCR) engagement of cognate peptide–major histocompatibility...
Articles
Biochem Soc Trans (2014) 42 (2): 284–288.
Published: 20 March 2014
..., cholesterol transport, mechanosensing and signal transduction. Caveolae provide an environment where multiple receptor signalling components are sequestered, clustered and compartmentalized for efficient signal transduction. Many of these receptors, including cytokine signal transducer gp130 (glycoprotein 130...
Articles
Biochem Soc Trans (2013) 41 (1): 89–94.
Published: 29 January 2013
...) palmitoylation serotonin (5-hydroxytryptamine) signal transduction Cellular as well as viral proteins often undergo post-translational modifications. One of these modifications is a covalent attachment of long-chain saturated fatty acids (i.e. palmitate) to cysteine residue(s) within the protein via...
Articles
Biochem Soc Trans (2011) 39 (2): 506–511.
Published: 22 March 2011
... molecular recognition at the cell surface and subsequent signal transduction processes central to the generation of an efficient immune response. Tetraspanins, both immune-cell-specific, such as CD37, and ubiquitously expressed, such as CD81, have been shown to be imp-ortant in both innate and adaptive...
Articles
Biochem Soc Trans (2011) 39 (1): 189–194.
Published: 19 January 2011
...Martha Radchenko; Mike Merrick P II proteins are one of the most widely distributed signal transduction proteins in Nature, being ubiquitous in bacteria, archaea and plants. They act by protein–protein interaction to control the activities of a wide range of enzymes, transcription factors...
Articles
Biochem Soc Trans (2010) 38 (4): 928–933.
Published: 26 July 2010
.... Despite the obvious and significant differences between these quite different physicochemical stimuli, the result is the same: the stressosome is phosphorylated by a key kinase to initiate the σ B cascade. The phosphorylation of the stressosome initiates a signal transduction system that up-regulates...
Articles
Biochem Soc Trans (2010) 38 (2): 583–587.
Published: 22 March 2010
... of floral meristems, among other functions. A major goal is to understand SUB-mediated signal transduction at the molecular level. Present evidence suggests that SUB affects neighbouring cells in a non-cell-autonomous fashion. In addition, our results indicate that SUB is an atypical, or kinase-dead, kinase...
Articles
Biochem Soc Trans (2009) 37 (6): 1254–1259.
Published: 19 November 2009
... m.j.cross@liv.ac.uk ). 5 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis big mitogen-activated protein kinase 1 (BMK1) endothelial cell extracellular-signal-regulated kinase 5 (ERK5) mitogen-activated protein kinase (MAPK) signal transduction...
Articles
Biochem Soc Trans (2009) 37 (6): 1167–1170.
Published: 19 November 2009
... and smoking. As circulating monocytes express functionally active VEGFR-1 (VEGF receptor 1) on their surface, monocytes and the related VEGFR-1-mediated signal transduction cascades have come into focus. The function of monocytes is negatively affected by diabetes mellitus, resulting in monocyte dysfunction...
Articles
Biochem Soc Trans (2009) 37 (4): 873–876.
Published: 22 July 2009
... and allergen on normal and asthmatic bronchial epithelial cells J. Immunol. 2002 169 407 414 25 Andrews A.L. Nasir T. Buccherri F. Holloway J.W. Holgate S.T. Davies D.E. IL-13Rα2; a regulator of IL-13 and IL-4 signal transduction J. Allergy Clin. Immunol. 2006 118 858...
Articles
Biochem Soc Trans (2008) 36 (6): 1448–1451.
Published: 19 November 2008
... receptor-bound protein 2) and Wsb-2 (WD40-repeat and SOCS box containing protein 2) with the cytoplasmic tail of the GCSFR [ 14 ]. cytokine receptor mammalian protein–protein interaction trap (MAPPIT) signal transducer and activator of transcription (STAT) signal transduction suppressor...
Articles
Biochem Soc Trans (2008) 36 (2): 229–234.
Published: 20 March 2008
... compilation © 2008 Biochemical Society 2008 cell adhesion integrin Rap1 signal transduction talin thrombosis Many integrins are expressed and remain in a low-affinity binding state until cellular stimulation transforms them into a high-affinity form, an event that can modify cell adhesion...
Articles
Biochem Soc Trans (2006) 34 (4): 502–503.
Published: 21 July 2006
... a reduced aggregation response after ADP stimulation, whether the alterations in cAMP contents have a functional effect still remains to be determined. cAMP compartmentalization heart failure phosphodiesterase 3B (PDE3B) phosphoinositide 3-kinase γ (PI3Kγ) signal transduction © 2006...
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Biochem Soc Trans (2005) 33 (6): 1323–1326.
Published: 26 October 2005
... The Biochemical Society 2005 biosensor cAMP cell imaging fluorescence resonance energy transfer (FRET) protein kinase A signal transduction cAMP is a ubiquitous second messenger that mediates the action of various hormones and neurotransmitters and influences many cell functions by cross-talk...
Articles
Biochem Soc Trans (2005) 33 (4): 649–651.
Published: 01 August 2005
... The Biochemical Society 2005 cell cycle RhoE Rho GTPase phosphorylation signal transduction RhoE is widely expressed, although its expression levels vary significantly between different cell types [ 3 , 4 ]. RhoE is found in both membrane and cytosolic fractions of cells, and localizes...
Articles
Biochem Soc Trans (2005) 33 (2): 354–357.
Published: 01 April 2005
... (email Juleen.Zierath@fyfa.ki.se ). 1 11 2004 © 2005 The Biochemical Society 2005 glucose uptake insulin insulin resistance kinase signal transduction skeletal muscle Type II diabetes At least 12 substrates of the insulin receptor have been identified so far: IRS-1...
Articles
Biochem Soc Trans (2005) 33 (1): 152–156.
Published: 01 February 2005
... in Azotobacter vinelandii integrates the signals of redox, fixed-nitrogen and carbon status to regulate nif transcription. Multidomain signalling interactions between NifL and NifA are modulated by redox changes, ligand binding and interaction with the signal-transduction protein GlnK. Under adverse redox...
Articles
Biochem Soc Trans (2005) 33 (1): 97–101.
Published: 01 February 2005
... the signal to a response regulator, which in turn controls transcription of the hydrogenase genes. © 2005 The Biochemical Society 2005 hydrogen metabolism molecular hydrogen Ralstonia eutropha regulatory hydrogenase regulatory hydrogenase–HoxJ complex signal transduction H 2...
Articles
Biochem Soc Trans (2005) 33 (1): 170–172.
Published: 01 February 2005
...A. Javelle; M. Merrick Ammonium transport proteins belonging to the Amt family are ubiquitous in prokaryotes. In Escherichia coli , the AmtB protein and the associated P II signal transduction protein (GlnK) have recently been recognized as an ammonium sensory system that effectively couples...
Articles
Biochem Soc Trans (2004) 32 (5): 781–784.
Published: 26 October 2004
... [ 6 – 10 ]. However, the molecular mechanisms by which Vav proteins and PI3K regulate calcium flux downstream of the BCR are not completely understood [ 11 , 12 ]. B-lymphocyte phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) signal transduction Vav Signalling Outwards...
Articles
Biochem Soc Trans (2004) 32 (6): 1075–1077.
Published: 26 October 2004
... reported work may suggest a possible role for Sab in targeting JNK to this subcellular compartment and/or mediating crosstalk between different signal-transduction pathways. 1 To whom correspondence should be addressed (email c.wiltshire@beatson.gla.ac.uk ). 5 7 2004 © 2004...
Articles
Biochem Soc Trans (2004) 32 (6): 1118–1121.
Published: 26 October 2004
...) protein signal transduction Figure 1 Structure and function of L-selectin ( A ) Structure of L-selectin. All the selectins have similar extracellular domains. E- and P-selectin have 6 and 9 sequence consensus repeats respectively, whereas L-selectin has only two. One possible reason...
Articles
Biochem Soc Trans (2004) 32 (1): 65–69.
Published: 01 February 2004
... evidence suggests that transient changes in cholesterol content may be important in regulating signal transduction. 1 To whom correspondence should be addressed (e-mail cfield@itsa.ucsf.edu ). 44th International Conference on the Bioscience of Lipids, a meeting held at Keble College, Oxford, 7–11...
Articles
Biochem Soc Trans (2003) 31 (6): 1198–1202.
Published: 01 December 2003
.... However, the precise signal transduction mechanism by which AngII transactivates EGFR/ErbB1 and whether other ErbBs are also required for AngII function remains unclear. Recent studies suggest an involvement of a metalloprotease-dependent ErbB family ligand production in the transactivation. Here, we...
Articles
Biochem Soc Trans (2003) 31 (6): 1488–1490.
Published: 01 December 2003
... of Sheffield, 21 July 2003 10 July 2003 © 2003 Biochemical Society 2003 epidermal growth factor receptor (EGFR) proteomics signal transduction small-molecule tyrosine kinase inhibitor surrogate marker two-dimensional electrophoresis Abbreviations used: SMTKI, small-molecule...
Articles
Biochem Soc Trans (2003) 31 (6): 1462–1471.
Published: 01 December 2003
... and that at least one mechanism for dealing with this heterogeneity is the assembly of signal transduction components into large multiprotein complexes. 1 To whom correspondence should be addressed (e-mail s.dower@sheffield.ac.uk ). Unravelling Nature's Networks a Biochemical Society Focused Meeting held...
Articles
Biochem Soc Trans (2003) 31 (6): 1281–1285.
Published: 01 December 2003
... training insulin sensitivity phosphoinositide 3-kinase (PI3K) signal transduction tumour necrosis factor α (TNF-α) Abbreviations used: Grb2, growth-factor-receptor-bound protein 2; GSK-3, glycogen synthase kinase 3; IL, interleukin; IRS-1, insulin receptor substrate-1; MAPK, mitogen...
Articles
Biochem Soc Trans (2003) 31 (3): 643–647.
Published: 01 June 2003
...L.A.J. O'Neill Signal-transduction pathways activated by Toll-like receptors (TLRs) have been the subject of intense investigation because of the key role played by TLRs in the recognition and elimination of microbes. Signalling is initiated by a domain termed the Toll/interleukin-1 (IL-1) receptor...
Articles
Biochem Soc Trans (2003) 31 (3): 648–651.
Published: 01 June 2003
... Society Focused Meeting held at Novartis, Horsham, 3 February 2003 20 January 2003 © 2003 Biochemical Society 2003 bacterial infection fruit fly innate immunity signal transduction Abbreviations used: PRR, pattern recognition receptor; TLR, Toll-like receptor; LPS...
Articles
Biochem Soc Trans (2003) 31 (3): 637–642.
Published: 01 June 2003
..., a Biochemical Society Focused Meeting held at Novartis, Horsham, 3 February 2003 10 February 2003 © 2003 Biochemical Society 2003 immune response interleukin interferon Myd88 signal transduction Toll-like receptor (TLR) Abbreviations used: TLR, Toll-like receptor; IL-1(R...
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Biochem Soc Trans (2003) 31 (1): 281–285.
Published: 01 February 2003
... B-cell receptor B-lymphocyte Fc receptor phosphatase signal transduction Abbreviations used: BCR, B-cell antigen receptor; BM, bone marrow; [Ca 2+ ] i , intracellular calcium concentration; ERK, extracellular signal-related protein kinase; FcR, Fc receptor; IL, interleukin; IMDM...
Articles
Biochem Soc Trans (2002) 30 (4): 807–811.
Published: 01 August 2002
... that characterize the signal transduction pathways utilized by this receptor complex to regulate B-cell intracellular calcium responses. complement homoeostasis signal transduction tyrosine phosphorylation BCR, B-cell antigen receptor Ca 2+ , intracellular calcium CD19 −/− mice, CD19-deficient mice...
Articles
Biochem Soc Trans (2001) 29 (6): 831–835.
Published: 01 November 2001
... 2001 © 2001 Biochemical Society 2001 apoptosis toxicity xenobiotic genetic disease signal transduction SPT, serine palmitoyltransferase Enzymes that Regulate Lipid Metabolism in Cell Signalling Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its...
Articles
Biochem Soc Trans (2001) 29 (6): 860–863.
Published: 01 November 2001
...P. J. Parker; S. J. Parkinson Protein kinase cascades feature in many signal transduction pathways. For those discussed here, a single upstream protein kinase appears to be responsible for the control of multiple downstream targets. So how is specificity introduced into these events...
Articles
Biochem Soc Trans (2001) 29 (4): 494–499.
Published: 01 August 2001
... in normal signal transduction and in the pathogenesis of a number of human diseases, such as cancer. Here we describe the functional roles of the caveolin gene family and summarize the evidence that supports a role for caveolae as mediators of a number of cellular signalling processes, including apoptosis...