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Keywords: signal transduction
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Articles
Biochem Soc Trans (2021) 49 (4): 1695–1709.
Published: 20 July 2021
.... Correspondence: Graham Ladds ( grl30@cam.ac.uk ) * These authors contributed equally to this work. adhesion receptors agonists G-protein-coupled receptors G-proteins signal transduction 24 5 2021 17 6 2021 18 6 2021 © 2021 The Author(s) 2021 This is an open access...
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Biochem Soc Trans (2021) 49 (2): 675–683.
Published: 16 April 2021
...). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer dimerization hippo pathway protein kinases SARAH domain signal transduction The Hippo pathway was originally discovered in Drosophila from genetic screens designed to identify pathways the regulate...
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Biochem Soc Trans (2020) 48 (2): 441–449.
Published: 22 April 2020
... and lipidation of other proteins. Examples include the kinases Akt1, CDK5 and GSK3β, the phosphatases calcineurin, PP2A and PHLPP, and the ubiquitin E3-ligase SKP2. The impact of FKBP51 on PTMs of signal transduction proteins significantly extends the functional versatility of this protein. As a stress-induced...
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Biochem Soc Trans (2017) 45 (1): 237–249.
Published: 15 February 2017
... modifications, and interactions. The cell co-ordinates these molecular events, on thousands of cellular proteins, in concert with environmental and physiological cues to fine-tune epigenetics, transcription, translation, signal transduction, cell cycle, and metabolism. The cellular stress response...
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Biochem Soc Trans (2017) 45 (1): 51–64.
Published: 15 February 2017
... on behalf of the Biochemical Society 2017 cancer growth factor microRNA non-coding RNA signal transduction While studying chemical carcinogenesis in the 1940s and examining the somatic mutation theory of cancer, Berenblum and Shubik [ 1 ] proposed a three-stage model of cancer development...
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Biochem Soc Trans (2017) 45 (1): 37–49.
Published: 15 February 2017
... and hyperphosphorylated AMPK, but decreased T 288 -phosphorylated AURKA levels. AURKA cilia ciliopathy human malignancy protein–serine–threonine kinases signal transduction Inoko and colleagues reported that Trichoplein (TCHP), originally identified as a keratin filament-binding scaffold protein [ 53...
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Biochem Soc Trans (2016) 44 (5): 1441–1454.
Published: 19 October 2016
..., or in conjunction with anti-angiogenic therapy or immunotherapy as a promising strategy for the treatment of human cancers. cancer immunotherapy signal transduction transforming growth factor-β tumor biology Transforming growth factor-β (TGF-β) is a ubiquitously expressed cytokine that mediates...
Articles
Biochem Soc Trans (2016) 44 (4): 1135–1141.
Published: 15 August 2016
...). published by Portland Press Limited on behalf of the Biochemical Society 2016 activin receptor-like kinase 1 (ALK1) bone morphogenetic protein 9 (BMP9) bone morphogenetic protein 10 (BMP10) BMP receptor type II (BMPR-II) endothelial cell signal transduction The endothelial bone...
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Biochem Soc Trans (2016) 44 (2): 452–459.
Published: 11 April 2016
... ( Figure 1 ). calcium endoplasmic reticulum (ER) inositol 1 4 5-trisphosphate receptor (IP3R) mitochondria-associated membrane (MAM) redox-dependent regulation sarco/endoplasmic reticulum Ca 2+ transport ATPase (SERCA) signal transduction The endoplasmic reticulum (ER) is the major...
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Biochem Soc Trans (2016) 44 (1): 273–278.
Published: 09 February 2016
... by Portland Press Limited 2016 AKT cancer phosphatase phosphoinositide 3-kinase signal transduction ubiquitin Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumour suppressor protein which dephosphorylates the cellular lipid signal phosphatidylinositol 3,4,5...
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Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
... 2016 inhibitor O-linked N -acetylglucosamine (O-GlcNAc) O-linked N -acetylglucosamine (O-GlcNAc) transferase post-translational modification protein structure signal transduction Protein O-linked N -acetylglucosamine (O-GlcNAc) post-translational modification is characterized...
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Biochem Soc Trans (2014) 42 (6): 1773–1779.
Published: 17 November 2014
... , 43 ] and IRAK3 [ 45 ] have recently been identified as molecules at signal transduction branch points. The Biological and Biomedical Consequences of Protein Moonlighting: A Biochemical Society Focused Meeting held at Charles Darwin House, London, U.K., 29–30 July 2014. Organized and Edited...
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Biochem Soc Trans (2014) 42 (6): 1506–1511.
Published: 17 November 2014
... 17 7 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 actin cell polarity microtubule protein kinase C (PKC) signal transduction T-cell These two cytoskeletal remodelling events serve as the foundation for IS structure and the basis for its function...
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Biochem Soc Trans (2014) 42 (6): 1538–1542.
Published: 17 November 2014
...) lipid signalling signal transduction Protein Kinase C Signalling in Health and Disease: A Biochemical Society Focused Meeting held at Science Gallery, Trinity College Dublin, Ireland, 24–25 June 2014. Organized and Edited by Aideen Long (Trinity College Dublin, Ireland) and Maria O’Connell...
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Biochem Soc Trans (2014) 42 (6): 1484–1489.
Published: 17 November 2014
...Pulak R. Nath; Noah Isakov Protein kinase Cθ (PKCθ) is a key enzyme in T-lymphocytes where it plays an important role in signal transduction downstream of the activated T-cell receptor (TCR) and the CD28 co-stimulatory receptor. Antigenic stimulation of T-cells triggers PKCθ translocation...
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Biochem Soc Trans (2014) 42 (6): 1584–1589.
Published: 17 November 2014
... S.H. Sharrocks A.D. Whitmarsh A.J. Transcriptional regulation by the MAP kinase signaling cascades Gene 2003 320 3 21 10.1016/S0378-1119(03)00816-3 14597384 4 Zhou G. Bao Z.Q. Dixon J.E. Components of a new human protein kinase signal transduction pathway J...
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Biochem Soc Trans (2014) 42 (2): 284–288.
Published: 20 March 2014
..., cholesterol transport, mechanosensing and signal transduction. Caveolae provide an environment where multiple receptor signalling components are sequestered, clustered and compartmentalized for efficient signal transduction. Many of these receptors, including cytokine signal transducer gp130 (glycoprotein 130...
Articles
Biochem Soc Trans (2013) 41 (1): 89–94.
Published: 29 January 2013
... the protein via a labile thioester linkage (palmitoylation). Among the cellular palmitoylated proteins, polypeptides involved in signal transduction [e.g. receptors, G-protein α-subunits and ACs (adenylate cyclases)] are prevalent. With the finding that palmitoylation states of several proteins may...
Articles
Biochem Soc Trans (2011) 39 (2): 506–511.
Published: 22 March 2011
... molecular recognition at the cell surface and subsequent signal transduction processes central to the generation of an efficient immune response. Tetraspanins, both immune-cell-specific, such as CD37, and ubiquitously expressed, such as CD81, have been shown to be imp-ortant in both innate and adaptive...
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Biochem Soc Trans (2011) 39 (1): 189–194.
Published: 19 January 2011
...Martha Radchenko; Mike Merrick P II proteins are one of the most widely distributed signal transduction proteins in Nature, being ubiquitous in bacteria, archaea and plants. They act by protein–protein interaction to control the activities of a wide range of enzymes, transcription factors...
Articles
Biochem Soc Trans (2010) 38 (4): 928–933.
Published: 26 July 2010
.... Despite the obvious and significant differences between these quite different physicochemical stimuli, the result is the same: the stressosome is phosphorylated by a key kinase to initiate the σ B cascade. The phosphorylation of the stressosome initiates a signal transduction system that up-regulates...
Articles
Biochem Soc Trans (2010) 38 (2): 583–587.
Published: 22 March 2010
... of floral meristems, among other functions. A major goal is to understand SUB-mediated signal transduction at the molecular level. Present evidence suggests that SUB affects neighbouring cells in a non-cell-autonomous fashion. In addition, our results indicate that SUB is an atypical, or kinase-dead, kinase...
Articles
Biochem Soc Trans (2009) 37 (6): 1167–1170.
Published: 19 November 2009
... and smoking. As circulating monocytes express functionally active VEGFR-1 (VEGF receptor 1) on their surface, monocytes and the related VEGFR-1-mediated signal transduction cascades have come into focus. The function of monocytes is negatively affected by diabetes mellitus, resulting in monocyte dysfunction...
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Biochem Soc Trans (2009) 37 (6): 1254–1259.
Published: 19 November 2009
... m.j.cross@liv.ac.uk ). 5 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis big mitogen-activated protein kinase 1 (BMK1) endothelial cell extracellular-signal-regulated kinase 5 (ERK5) mitogen-activated protein kinase (MAPK) signal transduction...
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Biochem Soc Trans (2008) 36 (6): 1448–1451.
Published: 19 November 2008
... cytokine receptors as the technique allows modification of the bait protein in a physiologically optimal environment. cytokine receptor mammalian protein–protein interaction trap (MAPPIT) signal transducer and activator of transcription (STAT) signal transduction suppressor of cytokine signalling...
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Biochem Soc Trans (2008) 36 (2): 229–234.
Published: 20 March 2008
... compilation © 2008 Biochemical Society 2008 cell adhesion integrin Rap1 signal transduction talin thrombosis Integrin adhesion receptors are glycosylated heterodimers composed of non-covalently associated type I transmembrane α and β subunits [ 1 – 3 ]. Each subunit contains a large...
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Biochem Soc Trans (2006) 34 (4): 502–503.
Published: 21 July 2006
...) phosphoinositide 3-kinase γ (PI3Kγ) signal transduction PI3Ks (phosphoinositide 3-kinases) are best known as a family of lipid and protein kinases involved in a large variety of cellular functions, ranging from regulation of metabolism, proliferation and survival to cytoskeletal organization and cell...
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Biochem Soc Trans (2005) 33 (6): 1323–1326.
Published: 26 October 2005
... The Biochemical Society 2005 biosensor cAMP cell imaging fluorescence resonance energy transfer (FRET) protein kinase A signal transduction cAMP is a ubiquitous second messenger that mediates the action of various hormones and neurotransmitters and influences many cell functions by cross-talk...
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Biochem Soc Trans (2005) 33 (4): 649–651.
Published: 01 August 2005
... be addressed (email a.ridley@ludwig.ucl.ac.uk ). 17 5 2005 © 2005 The Biochemical Society 2005 cell cycle RhoE Rho GTPase phosphorylation signal transduction ROCK I consists of an N-terminal kinase domain, followed by an extended region predicted to form a coiled coil, a Rho...
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Biochem Soc Trans (2005) 33 (1): 97–101.
Published: 01 February 2005
... complex signal transduction H 2 is an attractive energy source for many microorganisms including bacteria, archaea and lower eukaryotes. Most of the H 2 that is produced during fermentation is consumed by anaerobic microbes. Organisms that thrive in oxic environments probably receive H 2 only...
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Biochem Soc Trans (2005) 33 (1): 170–172.
Published: 01 February 2005
...A. Javelle; M. Merrick Ammonium transport proteins belonging to the Amt family are ubiquitous in prokaryotes. In Escherichia coli , the AmtB protein and the associated P II signal transduction protein (GlnK) have recently been recognized as an ammonium sensory system that effectively couples...
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Biochem Soc Trans (2005) 33 (1): 152–156.
Published: 01 February 2005
... in Azotobacter vinelandii integrates the signals of redox, fixed-nitrogen and carbon status to regulate nif transcription. Multidomain signalling interactions between NifL and NifA are modulated by redox changes, ligand binding and interaction with the signal-transduction protein GlnK. Under adverse redox...
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Biochem Soc Trans (2004) 32 (6): 1075–1077.
Published: 26 October 2004
... reported work may suggest a possible role for Sab in targeting JNK to this subcellular compartment and/or mediating crosstalk between different signal-transduction pathways. 1 To whom correspondence should be addressed (email c.wiltshire@beatson.gla.ac.uk ). 5 7 2004 © 2004...
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Biochem Soc Trans (2004) 32 (6): 1118–1121.
Published: 26 October 2004
...) protein signal transduction Figure 1 Structure and function of L-selectin ( A ) Structure of L-selectin. All the selectins have similar extracellular domains. E- and P-selectin have 6 and 9 sequence consensus repeats respectively, whereas L-selectin has only two. One possible reason...
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Biochem Soc Trans (2004) 32 (5): 781–784.
Published: 26 October 2004
...) signal transduction Vav Stimulation of the BCR (B-cell antigen receptor) results in the activation of protein tyrosine kinases and the recruitment of scaffold proteins leading to the assembly of a multiprotein complex, termed a signalsome. This complex regulates major signalling events...
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Biochem Soc Trans (2004) 32 (1): 65–69.
Published: 01 February 2004
... evidence suggests that transient changes in cholesterol content may be important in regulating signal transduction. 1 To whom correspondence should be addressed (e-mail cfield@itsa.ucsf.edu ). 44th International Conference on the Bioscience of Lipids, a meeting held at Keble College, Oxford, 7–11...
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Biochem Soc Trans (2003) 31 (6): 1198–1202.
Published: 01 December 2003
.... However, the precise signal transduction mechanism by which AngII transactivates EGFR/ErbB1 and whether other ErbBs are also required for AngII function remains unclear. Recent studies suggest an involvement of a metalloprotease-dependent ErbB family ligand production in the transactivation. Here, we...
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Biochem Soc Trans (2003) 31 (6): 1488–1490.
Published: 01 December 2003
... of Sheffield, 21 July 2003 10 July 2003 © 2003 Biochemical Society 2003 epidermal growth factor receptor (EGFR) proteomics signal transduction small-molecule tyrosine kinase inhibitor surrogate marker two-dimensional electrophoresis Abbreviations used: SMTKI, small-molecule...
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Biochem Soc Trans (2003) 31 (6): 1462–1471.
Published: 01 December 2003
... and that at least one mechanism for dealing with this heterogeneity is the assembly of signal transduction components into large multiprotein complexes. 1 To whom correspondence should be addressed (e-mail s.dower@sheffield.ac.uk ). Unravelling Nature's Networks a Biochemical Society Focused Meeting held...
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Biochem Soc Trans (2003) 31 (6): 1281–1285.
Published: 01 December 2003
... training insulin sensitivity phosphoinositide 3-kinase (PI3K) signal transduction tumour necrosis factor α (TNF-α) Abbreviations used: Grb2, growth-factor-receptor-bound protein 2; GSK-3, glycogen synthase kinase 3; IL, interleukin; IRS-1, insulin receptor substrate-1; MAPK, mitogen...
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Biochem Soc Trans (2003) 31 (3): 643–647.
Published: 01 June 2003
...L.A.J. O'Neill Signal-transduction pathways activated by Toll-like receptors (TLRs) have been the subject of intense investigation because of the key role played by TLRs in the recognition and elimination of microbes. Signalling is initiated by a domain termed the Toll/interleukin-1 (IL-1) receptor...
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Biochem Soc Trans (2003) 31 (3): 648–651.
Published: 01 June 2003
... Society Focused Meeting held at Novartis, Horsham, 3 February 2003 20 January 2003 © 2003 Biochemical Society 2003 bacterial infection fruit fly innate immunity signal transduction Abbreviations used: PRR, pattern recognition receptor; TLR, Toll-like receptor; LPS...
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Biochem Soc Trans (2003) 31 (3): 637–642.
Published: 01 June 2003
..., a Biochemical Society Focused Meeting held at Novartis, Horsham, 3 February 2003 10 February 2003 © 2003 Biochemical Society 2003 immune response interleukin interferon Myd88 signal transduction Toll-like receptor (TLR) Abbreviations used: TLR, Toll-like receptor; IL-1(R...
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Biochem Soc Trans (2003) 31 (1): 281–285.
Published: 01 February 2003
... B-cell receptor B-lymphocyte Fc receptor phosphatase signal transduction Abbreviations used: BCR, B-cell antigen receptor; BM, bone marrow; [Ca 2+ ] i , intracellular calcium concentration; ERK, extracellular signal-related protein kinase; FcR, Fc receptor; IL, interleukin; IMDM...
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Biochem Soc Trans (2001) 29 (6): 831–835.
Published: 01 November 2001
... 2001 © 2001 Biochemical Society 2001 apoptosis toxicity xenobiotic genetic disease signal transduction SPT, serine palmitoyltransferase Enzymes that Regulate Lipid Metabolism in Cell Signalling Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its...
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Biochem Soc Trans (2001) 29 (6): 860–863.
Published: 01 November 2001
...P. J. Parker; S. J. Parkinson Protein kinase cascades feature in many signal transduction pathways. For those discussed here, a single upstream protein kinase appears to be responsible for the control of multiple downstream targets. So how is specificity introduced into these events...
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Biochem Soc Trans (2001) 29 (4): 472–475.
Published: 01 August 2001
..., and it shares structural similarity with Vps27p, which is involved in vacuolar protein sorting in yeast. Since Hrs is localized to endosomes and has been implicated in the regulation of signal transduction as well as membrane trafficking, it has been regarded as a potential co-ordinator of endosomal receptor...