... by the recombinase. One group of these enzymes, the serine recombinases, initiates strand exchange by making double-strand breaks in the DNA of the two sites, in an intermediate built around a catalytic tetramer of recombinase subunits. However, these catalytic steps are only the culmination of a complex pathway...

... be addressed (email PRice@uchicago.edu ). 2 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 crossover site DNA-bending protein protein–DNA interaction recombination serine recombinase synaptosome Site-specific recombinases rearrange DNA by cutting...

...Femi J. Olorunniji; W. Marshall Stark The active-site interactions involved in the catalysis of DNA site-specific recombination by the serine recombinases are still incompletely understood. Recent crystal structures of synaptic γδ resolvase–DNA intermediates and biochemical analysis of Tn 3...

...Margaret C.M. Smith; William R.A. Brown; Andrew R. McEwan; Paul A. Rowley Most temperate phages encode an integrase for integration and excision of the prophage. Integrases belong either to the λ Int family of tyrosine recombinases or to a subgroup of the serine recombinases, the large serine...