... Rho GTPases septin The Rho GTPase family member Cdc42 regulates a diverse range of cellular functions including cytokinesis, cytoskeletal remodelling and cell polarity [ 1 , 2 ]. Like other Rho family members, Cdc42 cycles between two tightly regulated conformational states, a GTP-bound...

... they function together is poorly understood. Anillin can bind to numerous other furrow components, including F-actin, septins and myosin II, but its molecular functions are unclear. Recent data suggest that anillin participates in a previously unrecognized Rho-dependent pathway that can promote the association...

.... Lewellyn L. Desai A. Oegema K. Anillin and the septins promote asymmetric ingression of the cytokinetic furrow Dev. Cell 2007 12 827 835 9 Spiliotis E.T. Kinoshita M. Nelson W.J. A mitotic septin scaffold required for Mammalian chromosome congression and segregation...

... have a direct function in cytokinesis regulation. Tem1p, the small GTPase of the MEN complex, controls septin ring formation and regulates actomyosin dynamics during telophase [ 13 ]. The septins also have distinct functions in budding and fission yeast. In budding yeast, septins localize...