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Biochem Soc Trans (2020) 48 (1): 1–14.
Published: 12 February 2020
...Inge Grondman; Andrei Pirvu; Anca Riza; Mihai Ioana; Mihai G. Netea Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a dysregulated host response to infection. The main etiological causes of sepsis are bacterial, fungal, and viral infections. Last decades...
Includes: Supplementary data
Biochem Soc Trans (2015) 43 (4): 691–695.
Published: 03 August 2015
...) for the treatment of severe sepsis. Although originally deemed successful, Xigris was ultimately withdrawn due to lack of efficacy and an unacceptable bleeding risk. Despite this apparent failure, the problems that beset Xigris usage may be tractable using protein engineering approaches. In this review, we detail...
Biochem Soc Trans (2015) 43 (4): 715–719.
Published: 03 August 2015
... important interactions in the pathogenesis of cardiovascular infection. These interactions can trigger cardiac valve destruction in the case of endocarditis, multi-organ dysfunction in the case of sepsis and coagulopathy. Here, we review the interactions between S. aureus and endothelial cells and discuss...
Biochem Soc Trans (2007) 35 (5): 1264–1268.
Published: 25 October 2007
..., this speaker was unable to give this presentation at the meeting. This paper is included in the interest of completeness of the session. 7 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 adenosine ATP chemoreceptor inflammation sepsis ventilation 1...
Biochem Soc Trans (2006) 34 (6): 1028–1031.
Published: 25 October 2006
... sepsis signal transducer and activator of transcription 3 (STAT3) © 2006 The Biochemical Society 2006 23 6 2006 1 email Peter.email@example.com Many contradictory and confusing results have been published to account for the IL-10 mechanism and have recently been debated [ 3...
Biochem Soc Trans (2005) 33 (2): 401–405.
Published: 01 April 2005
... sepsis thrombosis The antithrombin–heparin pathway can modulate cellular responses by altering cellular responses to stimuli, thereby decreasing the inflammatory response [ 24 ]. In cultured endothelial cells, antithrombin binding to these cells increases prostacyclin formation [ 25 ] and decreases...
Biochem Soc Trans (2003) 31 (6): 1133–1136.
Published: 01 December 2003
... decarboxylase in response to, for example, alterations in glucose supply. Systemic inflammatory responses and sepsis lead to myocardial dysfunction as part of multiple system organ failure. We have shown that: (i) myocardial CPT I activity is inhibited during neonatal sepsis; (ii) on the basis of inhibitor...