.... Progerin expression results in a myriad of cellular phenotypes including abnormal nuclear morphology, loss of peripheral heterochromatin, transcriptional changes, DNA replication defects, DNA damage and premature cellular senescence. A key challenge is to elucidate how these different phenotypes...

...Kristina Kirschner; Nattaphong Rattanavirotkul; Megan F. Quince; Tamir Chandra Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence...

... that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases...

... of rapamycin (mTOR) to be a key modulator of aging and the use of mTOR inhibitors has been shown to ameliorate much age-related pathology; however, recent data suggest that senescent CD8 + T-cells function independently of mTOR. This review article will challenge the perceived dogma that mTOR universally...

... Biochemical Society 2014 aging cancer senescence skin stem cell Aging is a complex and detrimental process that is experienced by all living organisms. One of the most obvious signs of aging is the decay in the homoeostatic and regenerative potential of different tissues and organs...

... senescence and is a novel biomarker of human vascular aging Circulation 2010 121 2200 2210 58 Cao K. Blair C.D. Faddah D.A. Kieckhaefer J.E. Olive M. Erdos M.R. Nabel E.G. Collins F.S. Progerin and telomere dysfunction collaborate to trigger cellular senescence...

...-injury results in the eventual failure of epithelial cell repair due to replicative senescence are gaining favour. This is consistent with the onset of fibrotic diseases in middle age. Because epithelial injury often involves blood loss, inflammatory responses associated with the fibrotic response have...

... proliferation. However, hallmarks of OIS (oncogene-induced senescence) are evident that restrain further development of the tumour. 1 To whom correspondence should be addressed (email cap8@le.ac.uk ). 7 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 BRAF...

... cancer as an example. 1 email bchbh@nus.edu.sg 16 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antioxidant cancer cell culture oxidative damage oxidative stress senescence Oxygen is poisonous, and aerobic organisms survive its presence...

.... Alternatively, the link could be indirect and actin could be viewed as a cytosolic sensor of well-being within the cell. actin aging apoptosis mitochondrion programmed cell death senescence The yeast actin cytoskeleton is an essential structure that is organized into two major structures...

... motility, while ROS have also been implicated in apoptosis and cellular senescence, two mechanisms regarded as being anti-tumorigenic. This ‘two-faced’ character of free radicals will be discussed and placed in the context of the physiological conditions of the tumour cell, the different molecular...

... will necessarily be enriched in individuals that age more slowly than the average of that population. However, some investigators have suggested that, instead, individuals actually cease to senesce after a certain age. Here, using a new approach to determining the best-fit degree of heterogeneity in the Gompertz...

.... chlorophyll breakdown phytobilins senescence tetrapyrroles 1 E-mail Bernhard.Kraeutler@uibk.ac.at 11 3 2002 © 2002 Biochemical Society 2002 FCC, fluorescent chlorophyll catabolite NCC, non-fluorescent chlorophyll catabolite PaO, pheophorbide oxygenase RCC, red chlorophyll...

... factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological...

... in animals and humans. Although the evidence is strong that telomere shortening in late-passage human lymphocyte and non-lymphocytic cell lines induces a state in which the cells can no longer divide, there is no compelling evidence to suggest that replicative senescence of this kind is an important...