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Keywords: senescence
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Biochem Soc Trans (2020) 48 (3): 765–773.
Published: 05 May 2020
...Kristina Kirschner; Nattaphong Rattanavirotkul; Megan F. Quince; Tamir Chandra Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence...
Biochem Soc Trans (2019) 47 (4): 1157–1164.
Published: 31 July 2019
... that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases...
Biochem Soc Trans (2015) 43 (4): 734–739.
Published: 03 August 2015
... of rapamycin (mTOR) to be a key modulator of aging and the use of mTOR inhibitors has been shown to ameliorate much age-related pathology; however, recent data suggest that senescent CD8 + T-cells function independently of mTOR. This review article will challenge the perceived dogma that mTOR universally...
Biochem Soc Trans (2014) 42 (3): 663–669.
Published: 22 May 2014
... Biochemical Society 2014 aging cancer senescence skin stem cell Aging is a complex and detrimental process that is experienced by all living organisms. One of the most obvious signs of aging is the decay in the homoeostatic and regenerative potential of different tissues and organs...
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... senescence and is a novel biomarker of human vascular aging Circulation 2010 121 2200 2210 58 Cao K. Blair C.D. Faddah D.A. Kieckhaefer J.E. Olive M. Erdos M.R. Nabel E.G. Collins F.S. Progerin and telomere dysfunction collaborate to trigger cellular senescence...
Biochem Soc Trans (2009) 37 (4): 882–885.
Published: 22 July 2009
...-injury results in the eventual failure of epithelial cell repair due to replicative senescence are gaining favour. This is consistent with the onset of fibrotic diseases in middle age. Because epithelial injury often involves blood loss, inflammatory responses associated with the fibrotic response have...
Biochem Soc Trans (2007) 35 (5): 1329–1333.
Published: 25 October 2007
... proliferation. However, hallmarks of OIS (oncogene-induced senescence) are evident that restrain further development of the tumour. 1 To whom correspondence should be addressed (email cap8@le.ac.uk ). 7 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 BRAF...
Biochem Soc Trans (2007) 35 (5): 1147–1150.
Published: 25 October 2007
... cancer as an example. 1 email bchbh@nus.edu.sg 16 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antioxidant cancer cell culture oxidative damage oxidative stress senescence Oxygen is poisonous, and aerobic organisms survive its presence...
Biochem Soc Trans (2005) 33 (6): 1260–1264.
Published: 26 October 2005
.... Alternatively, the link could be indirect and actin could be viewed as a cytosolic sensor of well-being within the cell. actin aging apoptosis mitochondrion programmed cell death senescence The yeast actin cytoskeleton is an essential structure that is organized into two major structures...
Biochem Soc Trans (2003) 31 (6): 1441–1444.
Published: 01 December 2003
... motility, while ROS have also been implicated in apoptosis and cellular senescence, two mechanisms regarded as being anti-tumorigenic. This ‘two-faced’ character of free radicals will be discussed and placed in the context of the physiological conditions of the tumour cell, the different molecular...
Biochem Soc Trans (2003) 31 (2): 452–454.
Published: 01 April 2003
... will necessarily be enriched in individuals that age more slowly than the average of that population. However, some investigators have suggested that, instead, individuals actually cease to senesce after a certain age. Here, using a new approach to determining the best-fit degree of heterogeneity in the Gompertz...
Biochem Soc Trans (2002) 30 (4): 625–630.
Published: 01 August 2002
.... chlorophyll breakdown phytobilins senescence tetrapyrroles 1 E-mail Bernhard.Kraeutler@uibk.ac.at 11 3 2002 © 2002 Biochemical Society 2002 FCC, fluorescent chlorophyll catabolite NCC, non-fluorescent chlorophyll catabolite PaO, pheophorbide oxygenase RCC, red chlorophyll...
Biochem Soc Trans (2000) 28 (2): 233–240.
Published: 01 February 2000
... factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological...
Biochem Soc Trans (2000) 28 (2): 241–245.
Published: 01 February 2000
... in animals and humans. Although the evidence is strong that telomere shortening in late-passage human lymphocyte and non-lymphocytic cell lines induces a state in which the cells can no longer divide, there is no compelling evidence to suggest that replicative senescence of this kind is an important...