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Keywords: senescence
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Articles
Biochem Soc Trans (2023) 51 (4): 1485–1493.
Published: 30 June 2023
...Hilary J. Rogers Floral senescence is of fundamental interest in understanding plant developmental regulation, it is of ecological and agricultural interest in relation to seed production, and is of key importance to the production of cut flowers. The biochemical changes occurring are well-studied...
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Biochem Soc Trans (2020) 48 (3): 765–773.
Published: 05 May 2020
...Kristina Kirschner; Nattaphong Rattanavirotkul; Megan F. Quince; Tamir Chandra Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence...
Articles
Biochem Soc Trans (2019) 47 (4): 1157–1164.
Published: 31 July 2019
... that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases...
Articles
Biochem Soc Trans (2015) 43 (4): 734–739.
Published: 03 August 2015
... of rapamycin (mTOR) to be a key modulator of aging and the use of mTOR inhibitors has been shown to ameliorate much age-related pathology; however, recent data suggest that senescent CD8 + T-cells function independently of mTOR. This review article will challenge the perceived dogma that mTOR universally...
Articles
Biochem Soc Trans (2014) 42 (3): 663–669.
Published: 22 May 2014
... ], alterations in the epigenome [ 6 , 7 ], telomere attrition/dysfunction [ 8 , 9 ] or intrinsic senescence [ 10 ]. However, external influences can also affect the SC pool, such as changes in the local environment provided by the SC niche, direct cell–cell contact or alterations in the systemic milieu. 1...
Articles
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... 2011 alternative splicing laminopathy microRNA (miRNA) progeria senescence tumour suppressor The nuclear envelope is a complex structure that surrounds and protects the genome, playing essential roles in its regulation, organization and maintenance [ 1 ]. The nuclear envelope...
Articles
Biochem Soc Trans (2009) 37 (4): 882–885.
Published: 22 July 2009
...-injury results in the eventual failure of epithelial cell repair due to replicative senescence are gaining favour. This is consistent with the onset of fibrotic diseases in middle age. Because epithelial injury often involves blood loss, inflammatory responses associated with the fibrotic response have...
Articles
Biochem Soc Trans (2007) 35 (5): 1147–1150.
Published: 25 October 2007
... cancer as an example. 1 email bchbh@nus.edu.sg 16 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antioxidant cancer cell culture oxidative damage oxidative stress senescence Oxygen is poisonous, and aerobic organisms survive its presence...
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Biochem Soc Trans (2007) 35 (5): 1329–1333.
Published: 25 October 2007
... proliferation. However, hallmarks of OIS (oncogene-induced senescence) are evident that restrain further development of the tumour. 1 To whom correspondence should be addressed (email cap8@le.ac.uk ). 7 6 2007 As elucidated above, studies of human cancer samples have not only led...
Articles
Biochem Soc Trans (2005) 33 (6): 1260–1264.
Published: 26 October 2005
... death. 1 To whom correspondence should be addressed (email k.ayscough@sheffield.ac.uk ). 10 6 2005 © 2005 The Biochemical Society 2005 actin aging apoptosis mitochondrion programmed cell death senescence The yeast actin cytoskeleton is an essential structure...
Articles
Biochem Soc Trans (2003) 31 (6): 1441–1444.
Published: 01 December 2003
... motility, while ROS have also been implicated in apoptosis and cellular senescence, two mechanisms regarded as being anti-tumorigenic. This ‘two-faced’ character of free radicals will be discussed and placed in the context of the physiological conditions of the tumour cell, the different molecular...
Articles
Biochem Soc Trans (2003) 31 (2): 452–454.
Published: 01 April 2003
... will necessarily be enriched in individuals that age more slowly than the average of that population. However, some investigators have suggested that, instead, individuals actually cease to senesce after a certain age. Here, using a new approach to determining the best-fit degree of heterogeneity in the Gompertz...
Articles
Biochem Soc Trans (2002) 30 (4): 625–630.
Published: 01 August 2002
... E-mail Bernhard.Kraeutler@uibk.ac.at 11 3 2002 © 2002 Biochemical Society 2002 chlorophyll breakdown phytobilins senescence tetrapyrroles FCC, fluorescent chlorophyll catabolite NCC, non-fluorescent chlorophyll catabolite PaO, pheophorbide oxygenase RCC, red...
Articles
Biochem Soc Trans (2000) 28 (2): 233–240.
Published: 01 February 2000
... factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological...
Articles
Biochem Soc Trans (2000) 28 (2): 241–245.
Published: 01 February 2000
... in animals and humans. Although the evidence is strong that telomere shortening in late-passage human lymphocyte and non-lymphocytic cell lines induces a state in which the cells can no longer divide, there is no compelling evidence to suggest that replicative senescence of this kind is an important...