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Keywords: senescence
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Biochem Soc Trans (2020) 48 (3): 981–991.
Published: 15 June 2020
.... Progerin expression results in a myriad of cellular phenotypes including abnormal nuclear morphology, loss of peripheral heterochromatin, transcriptional changes, DNA replication defects, DNA damage and premature cellular senescence. A key challenge is to elucidate how these different phenotypes...
Biochem Soc Trans (2020) 48 (3): 765–773.
Published: 05 May 2020
...Kristina Kirschner; Nattaphong Rattanavirotkul; Megan F. Quince; Tamir Chandra Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence...
Biochem Soc Trans (2019) 47 (4): 1157–1164.
Published: 31 July 2019
... that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases...
Biochem Soc Trans (2015) 43 (4): 734–739.
Published: 03 August 2015
... of rapamycin (mTOR) to be a key modulator of aging and the use of mTOR inhibitors has been shown to ameliorate much age-related pathology; however, recent data suggest that senescent CD8 + T-cells function independently of mTOR. This review article will challenge the perceived dogma that mTOR universally...
Biochem Soc Trans (2014) 42 (3): 663–669.
Published: 22 May 2014
... the age-related alterations found in different tissue SC populations, highlighting recently identified changes in aged HFSCs (hair-follicle SCs) in the skin. 20 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 aging cancer senescence skin stem cell...
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
..., favouring a decrease in cellular proliferation rates accompanied by an increase in apoptosis and senescence. These processes result in the loss of tissue and organism homoeostasis. In parallel, a chronic stress response cause changes in the transcriptional profiles of several somatotroph axis key regulators...
Biochem Soc Trans (2009) 37 (4): 882–885.
Published: 22 July 2009
...-injury results in the eventual failure of epithelial cell repair due to replicative senescence are gaining favour. This is consistent with the onset of fibrotic diseases in middle age. Because epithelial injury often involves blood loss, inflammatory responses associated with the fibrotic response have...
Biochem Soc Trans (2007) 35 (5): 1329–1333.
Published: 25 October 2007
... proliferation. However, hallmarks of OIS (oncogene-induced senescence) are evident that restrain further development of the tumour. 7 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 BRAF cancer Cre-Lox genetically engineered mouse model proliferation senescence...
Biochem Soc Trans (2007) 35 (5): 1147–1150.
Published: 25 October 2007
... cancer as an example. 1 email bchbh@nus.edu.sg 16 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antioxidant cancer cell culture oxidative damage oxidative stress senescence Oxygen is poisonous, and aerobic organisms survive its presence...
Biochem Soc Trans (2005) 33 (6): 1260–1264.
Published: 26 October 2005
... that senescent cells have higher levels of SM22/transgelin. Additionally, reduced levels of SM22 have been reported in several tumour cell lines [ 29 ]. Further studies on yeast and mammalian cells might now shed light on the process of cell aging and, in particular, how this process is linked to the normal...
Biochem Soc Trans (2003) 31 (6): 1441–1444.
Published: 01 December 2003
... motility, while ROS have also been implicated in apoptosis and cellular senescence, two mechanisms regarded as being anti-tumorigenic. This ‘two-faced’ character of free radicals will be discussed and placed in the context of the physiological conditions of the tumour cell, the different molecular...
Biochem Soc Trans (2003) 31 (2): 452–454.
Published: 01 April 2003
... will necessarily be enriched in individuals that age more slowly than the average of that population. However, some investigators have suggested that, instead, individuals actually cease to senesce after a certain age. Here, using a new approach to determining the best-fit degree of heterogeneity in the Gompertz...
Biochem Soc Trans (2002) 30 (4): 625–630.
Published: 01 August 2002
... on Earth, observable even from outer space [24 ] . Only in the last decade has the breakdown of chlorophyll in plants begun to yield some of its mysteries [2-61. Matile and co-workers provided the first evidence for the presence of non-green chlorophyll catabolites in senescent leaves of vas- cular plants...
Biochem Soc Trans (2000) 28 (2): 233–240.
Published: 01 February 2000
... factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological...
Biochem Soc Trans (2000) 28 (2): 241–245.
Published: 01 February 2000
... in animals and humans. Although the evidence is strong that telomere shortening in late-passage human lymphocyte and non-lymphocytic cell lines induces a state in which the cells can no longer divide, there is no compelling evidence to suggest that replicative senescence of this kind is an important...