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Keywords: self-renewal
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Biochem Soc Trans (2021) 49 (6): 2941–2955.
Published: 02 December 2021
... processes related to cytoskeletal dynamics, polarity and gene transcription. In the last decade, major new advances have been made in understanding the regulatory role and mechanism of Rho GTPases in self-renewal, differentiation, migration, and lineage specification in tissue-specific signaling mechanisms...
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Biochem Soc Trans (2007) 35 (2): 225–228.
Published: 20 March 2007
... for optimal maintenance of self-renewal, since inhibition of PI3K signalling (with either 5 μM LY294002 or upon expression of a dominant-negative class I A PI3K mutant) in the presence of LIF led to loss of self-renewal [ 32 ], with cells under going multi-lineage differentiation (E. Kingham and M. J. Welham...
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Biochem Soc Trans (2005) 33 (6): 1531–1533.
Published: 26 October 2005
... correspondence should be addressed (email dominique.bonnet@cancer.org.uk ). 17 6 2005 © 2005 The Biochemical Society 2005 cancer stem cell (CSC) haematopoietic stem cell (HSC) leukaemic stem cell (LSC) self-renewal tumour xenotransplantation model The hallmark properties of HSCs...
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Biochem Soc Trans (2005) 33 (6): 1518–1521.
Published: 26 October 2005
...A. Yates; I. Chambers Intrinsic regulators of the pluripotency of mouse ES (embryonic stem) cells include the homeodomain proteins Oct4 and the recently identified Nanog. When overexpressed, Nanog displays the unique attribute of robustly sustaining ES cell self-renewal in the absence...