... processes related to cytoskeletal dynamics, polarity and gene transcription. In the last decade, major new advances have been made in understanding the regulatory role and mechanism of Rho GTPases in self-renewal, differentiation, migration, and lineage specification in tissue-specific signaling mechanisms...

... Journal compilation © 2011 Biochemical Society 2011 cell cycle embryonic stem cell glycogen synthase kinase 3 (GSK-3) phosphoinositide 3-kinase (PI3K) pluripotency proliferation self-renewal CDK cyclin-dependent kinase ESC embryonic stem cell Esrrb oestrogen-related...

... self-renewal ES cell lines exhibit the unique property of pluripotency, i.e. the ability to differentiate into all cell lineages comprising the adult organism [ 1 , 2 ]. Pluripotency is underpinned by ES cell self-renewal, the term given to the symmetrical division of ES cells to generate two...

...A. Yates; I. Chambers Intrinsic regulators of the pluripotency of mouse ES (embryonic stem) cells include the homeodomain proteins Oct4 and the recently identified Nanog. When overexpressed, Nanog displays the unique attribute of robustly sustaining ES cell self-renewal in the absence...

... correspondence should be addressed (email dominique.bonnet@cancer.org.uk ). 17 6 2005 © 2005 The Biochemical Society 2005 cancer stem cell (CSC) haematopoietic stem cell (HSC) leukaemic stem cell (LSC) self-renewal tumour xenotransplantation model The hallmark properties of HSCs...