... benzodiazepine receptor (PBR)28 plasma free fraction positron emission tomography schizophrenia translocator protein (TSPO) Positron emission tomography (PET) is an imaging technology that assays the distribution of ligands labelled with positron emitters (e.g., 18 F, 11 C, 15 O) in vivo...

... for these treatment-resistant symptoms. In the present article, we describe a unique research approach to identify the causative process in the pathophysiology of a subset of schizophrenia. Our findings could form the basis of a schizophrenia subtype classification within this very heterogeneous disease...

... 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 copy number variation microtubule neurodegenerative disorder schizophrenia tau CNVs (copy number variations) are unbalanced structural variations of genomic DNA, such as duplications and deletions. They have...

... dysregulation of Ca 2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease. 1 email michael.berridge@babraham.ac.uk 13 12 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012...

... rheumatoid arthritis schizophrenia Glycosylation is one of the most abundant and complex post-translational modifications, with its importance underlined by the fact that it has an impact upon protein function. Aberrant glycosylation plays a pivotal role in a multitude of physiological states...

...Matt W. Jones Most complex psychiatric disorders cannot be explained by pathology of a single brain region, but arise as a consequence of dysfunctional interactions between brain regions. Schizophrenia, in particular, has been described as a ‘disconnection syndrome’, but similar principles...

... and ideation are encoded by the genome is a key question in biology. Identification of sets of genes underlying human mental disorders is a path towards this objective. Schizophrenia is a common disease with cognitive symptoms, high heritability and complex genetics. We have identified genes involved...

... or schizophrenia are considered to manifest themselves through a dysregulation of the inhibitory interneuron ‘clocking’ network as a final common denominator, irrespective of the diverse underlying disease pathologies. The diversity of GABAergic interneurons is paralleled by a corresponding diversity of GABA...

...Lieve Desbonnet; John L. Waddington; Colm M.P. O'Tuathaigh Schizophrenia is a highly complex and heritable psychiatric disorder in which multiple genes and environmental factors interact to cause the schizophrenia phenotype. A new generation of molecular studies has yielded numerous candidate genes...

...N.J. Brandon D isrupted i n sc hizophrenia 1 ( DISC1 ) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All...

...G.P. Reynolds; M.K. Harte There is an accumulation of evidence for abnormalities in schizophrenia of both the major neurotransmitter systems of the brain – those of GABA (γ-aminobutyric acid) and glutamate. Initial studies have found deficits in the putative neuronal marker, N -acetylaspartate...