... benzodiazepine receptor (PBR)28 plasma free fraction positron emission tomography schizophrenia translocator protein (TSPO) Figure 3 The effect of correcting for endothelial binding and plasma variability, two of the main factors affecting quantification of TSPO ligand, on the final end-point...

... for these treatment-resistant symptoms. In the present article, we describe a unique research approach to identify the causative process in the pathophysiology of a subset of schizophrenia. Our findings could form the basis of a schizophrenia subtype classification within this very heterogeneous disease...

... biologic pathways in schizophrenia, autism, and mental retardation Arch. Gen. Psychiatry 2009 66 947 956 21 Rovelet-Lecrux A. Hannequin D. Guillin O. Legallic S. Jurici S. Wallon D. Frebourg T. Campion D. Frontotemporal dementia phenotype associated with MAPT...

... dysregulation of Ca 2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease. Ca 2+ pumps and exchangers are responsible for pumping Ca 2+ out of the cell or back into the ER. These pumps and exchangers operate...

... to enhance the efficacy and efficiency of the diagnostic procedures for these diseases. biomarker cancer glycosylation rheumatoid arthritis schizophrenia Glycosylation is one of the most abundant and complex post-translational modifications, with its importance underlined by the fact...

...Matt W. Jones Most complex psychiatric disorders cannot be explained by pathology of a single brain region, but arise as a consequence of dysfunctional interactions between brain regions. Schizophrenia, in particular, has been described as a ‘disconnection syndrome’, but similar principles...

... and ideation are encoded by the genome is a key question in biology. Identification of sets of genes underlying human mental disorders is a path towards this objective. Schizophrenia is a common disease with cognitive symptoms, high heritability and complex genetics. We have identified genes involved...

... or schizophrenia are considered to manifest themselves through a dysregulation of the inhibitory interneuron ‘clocking’ network as a final common denominator, irrespective of the diverse underlying disease pathologies. The diversity of GABAergic interneurons is paralleled by a corresponding diversity of GABA...

...Lieve Desbonnet; John L. Waddington; Colm M.P. O'Tuathaigh Schizophrenia is a highly complex and heritable psychiatric disorder in which multiple genes and environmental factors interact to cause the schizophrenia phenotype. A new generation of molecular studies has yielded numerous candidate genes...

...N.J. Brandon D isrupted i n sc hizophrenia 1 ( DISC1 ) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All...

...G.P. Reynolds; M.K. Harte There is an accumulation of evidence for abnormalities in schizophrenia of both the major neurotransmitter systems of the brain – those of GABA (γ-aminobutyric acid) and glutamate. Initial studies have found deficits in the putative neuronal marker, N -acetylaspartate...