... Society 2015 cardiac muscle intracellular Ca 2+ dynamics ryanodine receptor sarcoplasmic reticulum zinc signalling Zinc is an essential trace element which is known to interact with more than 10% of the human proteome [ 1 ]. The biological importance of zinc beyond its identified roles...

...Fiona O'Brien; Elisa Venturi; Rebecca Sitsapesan Once opened, ryanodine receptors (RyR) are efficient pathways for the release of Ca 2+ from the endoplasmic/sarcoplasmic reticulum (ER/SR). The precise nature of the Ca 2+ -release event, however, requires fine-tuning for the specific process...

... (sarcoplasmic reticulum) calcium release channel in triggering arrhythmias. Mutant RyR2 channels give rise to spontaneous release of calcium (Ca 2+ ) from the SR during diastole, which enhances the probability of ventricular arrhythmias. Several molecular mechanisms have been proposed to explain the gain...

... calcium signalling reactive oxygen species redox regulation ryanodine receptor sarcoplasmic reticulum thiol modification The RyR (ryanodine receptor) is an intracellular ion channel mediating Ca 2+ release from intracellular stores. Mammals express three RyR isoforms in both excitable and non...

... 22 April 2003 © 2003 Biochemical Society 2003 calcium cardiac polyunsaturated fatty acid sarcoplasmic reticulum Abbreviations used: PUFA, polyunsaturated fatty acid; CICR, calcium-induced calcium release; SR, sarcoplasmic reticulum; EPA, eicosapentaenoic acid. Calcium...

...T. Kamishima; J.M. Quayle Ca 2+ influx across plasma membranes may trigger Ca 2+ release by activating ryanodine-sensitive receptors in the sarcoplasmic reticulum. This process is called Ca 2+ -induced Ca 2+ release, and may be important in regulating cytosolic Ca 2+ concentration ([Ca 2+ ] i...