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Keywords: salt-inducible kinase (SIK)
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Biochem Soc Trans (2014) 42 (1): 11–24.
Published: 23 January 2014
... (PI3K) salt-inducible kinase (SIK) Toll-like receptor (TLR) In contrast with the production of pro-inflammatory cytokines, the Tpl2/MKK1/ERK1/2 cascade limits the production of Type I IFNs in macrophages. Genetic deletion of Tpl2 or pharmacological inhibition of MKK1 prevents ERK1/2 activation...