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Keywords: ryanodine receptor
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Articles
Biochem Soc Trans (2016) 44 (2): 534–540.
Published: 11 April 2016
... implications, with special emphasis on the emerging contributions of cryo-ET. 1 email ruben@biochem.mpg.de 15 1 2016 © 2016 Authors; published by Portland Press Limited 2016 cryo-EM extended-synaptotagmin lipid transfer Orai ryanodine receptor STIM Compartmentalization...
Articles
Biochem Soc Trans (2015) 43 (3): 405–409.
Published: 01 June 2015
...-evoked signals, which may instead be mediated by activation of ryanodine receptors (RyRs). A prime candidate for mediating this coupling between I-mGluR activation and RyR opening is cyclic ADP ribose (cADPR) and, indeed, several of these PLC-/IP 3 -independent I-mGluR-evoked calcium signals have now...
Articles
Biochem Soc Trans (2015) 43 (3): 426–433.
Published: 01 June 2015
...Fiona O'Brien; Elisa Venturi; Rebecca Sitsapesan Once opened, ryanodine receptors (RyR) are efficient pathways for the release of Ca 2+ from the endoplasmic/sarcoplasmic reticulum (ER/SR). The precise nature of the Ca 2+ -release event, however, requires fine-tuning for the specific process...
Articles
Biochem Soc Trans (2015) 43 (3): 377–383.
Published: 01 June 2015
...Monika Seidel; F. Anthony Lai; Spyros Zissimopoulos The ryanodine receptor/Ca 2+ release channel plays a pivotal role in skeletal and cardiac muscle excitation–contraction coupling. Defective regulation leads to neuromuscular disorders and arrhythmogenic cardiac disease. This mini-review focuses...
Articles
Biochem Soc Trans (2015) 43 (3): 359–363.
Published: 01 June 2015
... linked to intracellular calcium signalling. In this review, we discuss the role of zinc as an intracellular signalling molecule with an emphasis on the potential role of zinc in shaping calcium-dynamics in cardiac muscle. We also consider the evidence that the cardiac ryanodine receptor (RyR2...
Articles
Biochem Soc Trans (2014) 42 (1): 63–70.
Published: 23 January 2014
... structural changes are thought to allow gating of ryanodine receptors. cAMP increases the sensitivity of IP 3 Rs and thereby potentiates the Ca 2+ signals evoked by receptors that stimulate IP 3 formation. We speculate that both IP 3 and cAMP are delivered to IP 3 Rs within signalling junctions, wherein...
Articles
Biochem Soc Trans (2006) 34 (5): 919–921.
Published: 25 October 2006
...S. Zissimopoulos; F.A. Lai The RyR (ryanodine receptor)/calcium release channel contains a number of highly reactive thiol groups that endow it with redox sensitivity. In general, oxidizing conditions favour channel opening, while reducing conditions have the opposite effect. Thiol modification...
Articles
Biochem Soc Trans (2006) 34 (3): 370–373.
Published: 22 May 2006
... (AMFR) calcium endoplasmic reticulum-associated degradation (ERAD) mitochondrion ryanodine receptor smooth endoplasmic reticulum The ER is a continuous membrane system that consists of multiple domains that perform different functions [ 1 ]. These include translocation of secretory proteins...
Articles
Biochem Soc Trans (2003) 31 (5): 920–924.
Published: 01 October 2003
... centres on whether or not Ca 2+ released from the Ins P 3 receptor activates RyRs (ryanodine receptors) to generate further release by Ca 2+ -induced Ca 2+ release and propagate waves or whether the entire process arises from Ins P 3 receptor activity alone. Under normal physiological conditions the [Ca 2...
Articles
Biochem Soc Trans (2003) 31 (5): 943–946.
Published: 01 October 2003
... remains unclear. It has been suggested Key words: Ca2+ channel, Ca2+ spark, Fura-2, ion channel, ryanodine receptor, sarcoplasmic reticulum. Abbreviations used: [Ca2+]i , intracellular calcium concentration; STOC, spontaneous transient outward current; STIC, spontaneous transient inward current. 1To whom...