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Keywords: rolipram
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Articles

Phosphodiesterase-4 gates the ability of protein kinase A to phosphorylate G-protein receptor kinase-2 and influence its translocation

M.D. Houslay, G.S. Baillie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (4): 474–475.
DOI: https://doi.org/10.1042/BST0340474
Published: 21 July 2006
...-protein receptor kinase-2). This response was enhanced when PDE4 (phosphodiesterase-4) activity was attenuated using either rolipram, a PDE4-selective inhibitor, or with siRNA (small interfering RNA) knockdown of both PDE4B and PDE4D. Rolipram also facilitated GRK2 recruitment to the membrane...
View article titled, Phosphodiesterase-4 gates the ability of protein kinase A to phosphorylate G-protein receptor kinase-2 and influence its translocation
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Articles

The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways

M.D. Houslay, G.S. Baillie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1186–1190.
DOI: https://doi.org/10.1042/bst0311186
Published: 01 December 2003
... 2003 19 May 2003 © 2003 Biochemical Society 2003 arrestin cAMP extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAP kinase) phosphodiesterase rolipram Abbreviations used: ERK, extracellular-signal-regulated kinase; PKA, protein kinase...
View article titled, The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways
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