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Keywords: ribosomes
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Biochem Soc Trans (2024) 52 (1): 465–479.
Published: 23 February 2024
... pathological alterations are not fully understood. Given the crucial roles of the SMN protein in snRNP biogenesis and its interactions with ribosomes and translation-related proteins and mRNAs, a decrease in SMN levels below a specific threshold in SMA is expected to affect translational control of gene...
Biochem Soc Trans (2023) 51 (3): 959–969.
Published: 15 June 2023
... findings on mechanisms of elongation control mediated by ribosome pausing and collisions and the availability of tRNAs and elongation factors. We also discuss how elongation intersects with distinct modes of translation control, further supporting cellular viability and gene expression reprogramming...
Biochem Soc Trans (2022) 50 (6): 1715–1724.
Published: 09 December 2022
... is inhibited, such as during the integrated stress response (ISR), and may facilitate cellular adaptation to stress. The ribosome-associated quality control (RQC) pathway is a critical translation monitoring system that recognizes aberrant mRNAs encoding potentially toxic nascent peptides to target them...
Biochem Soc Trans (2018) 46 (6): 1529–1539.
Published: 12 November 2018
...Christian Bates; Simon J. Hubbard; Mark P. Ashe The regulation of translation is critical in almost every aspect of gene expression. Nonetheless, the ribosome is historically viewed as a passive player in this process. However, evidence is accumulating to suggest that variations in the ribosome can...
Biochem Soc Trans (2017) 45 (2): 339–351.
Published: 13 April 2017
... degrade mRNAs as a consequence of their translation, were considered to be exceptions to this rule. Recently, however, it has become clear that many mRNAs are degraded co-translationally, and it has emerged that codon choice, by influencing the rate of ribosome elongation, affects the rate of mRNA decay...