... the pharmacokinetics and pharmacodynamics are dissociated. The three murine models to be discussed each show BiP induced long-term therapeutic protection and therefore has potential for long-lasting drug-free therapy in rheumatoid arthritis (RA). During the pre-clinical investigations for rhuBiP, we used three...

... that there was a significant, but weak, relationship with age. Interestingly, patients with rheumatoid arthritis and cancer have been described by others to secrete or express greater surface Trx-1 than predicted. It is interesting to speculate whether a decline in Trx-1 during ageing protects against such conditions...

...Usman Ahmed; Paul J. Thornalley; Naila Rabbani OA (osteoarthritis) and RA (rheumatoid arthritis) lead to deterioration of the joints. Early OA is associated with loss of bone due to increased bone remodelling. A role for inflammation is thought to be integral to the pathology. RA is a chronic...

... interleukin LAS low-abundant protein PSA prostate-specific antigen RA rheumatoid arthritis sLe x sialyl-Lewis X Work in our laboratory is supported by the European Commission under the Seventh Framework Programme (FP7) (SchizDX [grant number 223427], EuroGlycoArrays [grant...

... for VEGF 165 b than VEGF 165 , indicating that the difference in affinity needs to be accounted for [ 27 ]. angiogenesis carcinoma sample Denys–Drash syndrome human vitreous fluid rheumatoid arthritis vasculogenesis VEGF has become a centre of intense interest due to its essential role...

...K.A. Reedquist; J. Ludikhuize; P.P. Tak Although the mechanisms leading to the induction of RA (rheumatoid arthritis) are poorly understood, improper activation, proliferation, survival and retention of neutrophils, macrophages, lymphocytes and other leucocytes contribute to perpetuation...

... subjects with MBL deficiency remain healthy. MBL deficiency is also associated with non-infectious diseases including systemic lupus erythematosus, rheumatoid arthritis, cystic fibrosis and common variable immunodeficiency. MBL deficiency may affect susceptibility to (e.g. meningococcal disease), or alter...

...S. Baig; Y. Patel; P. Coussons; R. Grant Erythropoietin (EPO), a haemopoietic growth factor and a primary regulator of erythropoiesis, is widely used to treat anaemia in various chronic complications of rheumatoid arthritis (RA). Fibro-blast-like cells, found in the pannus tissue of joints...