... clamp loader to the replisome, supporting processive DNA synthesis, DNA damage response signalling as well as sister chromatid cohesion. In this minireview, we discuss recent biochemical and structural work that begins to explain various aspects of eukaryotic chromosome replication, with a focus...

...Huilin Li; Nina Y. Yao; Michael E. O'Donnell The replication of DNA in chromosomes is initiated at sequences called origins at which two replisome machines are assembled at replication forks that move in opposite directions. Interestingly, in vivo studies observe that the two replication forks...

... was proposed to relate to the differential manner in which DNA damage is overcome depending on whether the replisome collides with a naked lesion or a stalled RNAP. That such a difference is observed is entirely consistent with replication forks colliding more frequently with stalled RNAP following UV...

.... To date, there has been only a single report describing a systematic screening approach to define the protein–protein interaction network of the archaeal replisome [ 25 ]. Using the Y2H (yeast two-hybrid) system, with candidate Archaeoglobus fulgidus replication factors as baits, a number of novel...

... at multiple discrete sites on each chromosome known as replication origins [ 13 ]. Origins are bound by the ORC which acts as a landing pad for the related Cdc6 protein. In collaboration with Cdt1, Cdc6 then promotes further assembly of replisome components at the origin, including the MCM (minichromosome...