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Keywords: replisome
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Biochem Soc Trans (2022) 50 (1): 309–320.
Published: 07 February 2022
... clamp loader to the replisome, supporting processive DNA synthesis, DNA damage response signalling as well as sister chromatid cohesion. In this minireview, we discuss recent biochemical and structural work that begins to explain various aspects of eukaryotic chromosome replication, with a focus...
Biochem Soc Trans (2020) 48 (6): 2769–2778.
Published: 10 December 2020
...Huilin Li; Nina Y. Yao; Michael E. O'Donnell The replication of DNA in chromosomes is initiated at sequences called origins at which two replisome machines are assembled at replication forks that move in opposite directions. Interestingly, in vivo studies observe that the two replication forks...
Biochem Soc Trans (2014) 42 (1): 25–34.
Published: 23 January 2014
... The Authors Journal compilation © 2014 Biochemical Society 2014 discontinuous replication DNA damage DNA replication leading-strand priming replisome In the 60 years since Watson and Crick published their model for the structure of the DNA double helix [ 1 ], a vast amount has been learnt...
Biochem Soc Trans (2011) 39 (1): 163–168.
Published: 19 January 2011
... Biochemical Society 2011 archaeon chromosome replication DNA replication protein–protein interaction replication machinery replisome In all forms of cellular life, chromosomal DNA replication requires the complex interplay of a large number of essential and non-essential protein factors...
Biochem Soc Trans (2009) 37 (1): 108–113.
Published: 20 January 2009
... origins [ 13 ]. Origins are bound by the ORC which acts as a landing pad for the related Cdc6 protein. In collaboration with Cdt1, Cdc6 then promotes further assembly of replisome components at the origin, including the MCM (minichromosome maintenance) helicase (discussed below) [ 13 ]. In archaeal cells...