... clamp loader to the replisome, supporting processive DNA synthesis, DNA damage response signalling as well as sister chromatid cohesion. In this minireview, we discuss recent biochemical and structural work that begins to explain various aspects of eukaryotic chromosome replication, with a focus...

...Huilin Li; Nina Y. Yao; Michael E. O'Donnell The replication of DNA in chromosomes is initiated at sequences called origins at which two replisome machines are assembled at replication forks that move in opposite directions. Interestingly, in vivo studies observe that the two replication forks...

... The Authors Journal compilation © 2014 Biochemical Society 2014 discontinuous replication DNA damage DNA replication leading-strand priming replisome In the 60 years since Watson and Crick published their model for the structure of the DNA double helix [ 1 ], a vast amount has been learnt...

... Biochemical Society 2011 archaeon chromosome replication DNA replication protein–protein interaction replication machinery replisome In all forms of cellular life, chromosomal DNA replication requires the complex interplay of a large number of essential and non-essential protein factors...

... origins [ 13 ]. Origins are bound by the ORC which acts as a landing pad for the related Cdc6 protein. In collaboration with Cdt1, Cdc6 then promotes further assembly of replisome components at the origin, including the MCM (minichromosome maintenance) helicase (discussed below) [ 13 ]. In archaeal cells...