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Keywords: replicative senescence
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Biochem Soc Trans (2021) 49 (2): 933–943.
Published: 26 March 2021
... as replicative senescence. During senescence, the actions of both these apical kinases and telomere-binding proteins allow checkpoint activation while bulk DNA repair activities at telomeres are still inhibited. Checkpoint-mediated cell cycle arrest also prevents further telomere erosion and deprotection...