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Keywords: replication stress
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Biochem Soc Trans (2023) 51 (3): 1289–1295.
Published: 05 May 2023
... of the loading of the hexamer onto chromatin and its activation as the replicative helicase. MCM2–7 is highly abundant in proliferating cells, which confers resistance to replication stress. Thus, the presence of an excess of MCM2–7 is important for maintaining genome integrity. However, the mechanism via which...
Biochem Soc Trans (2022) 50 (5): 1471–1480.
Published: 05 October 2022
...-mediated degradation of CLASPIN, driven by APC/C CDH1 and SCF βTrCP , results in a cell-cycle-dependent fluctuation pattern of CLASPIN levels, with peak levels seen in S/G2 phase when it functions in the DNA replisome or as an adaptor protein in ATR–CHK1 signaling under replication stress. Deubiquitination...
Biochem Soc Trans (2021) 49 (3): 1251–1263.
Published: 18 May 2021
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. DDR ER stress hypoxia radiation replication stress UPR Oxygen homeostasis in eukaryotes is essential in order to maintain aerobic metabolism and intracellular bioenergetics. Due to the high...
Includes: Supplementary data
Biochem Soc Trans (2013) 41 (6): 1720–1725.
Published: 20 November 2013
... Society 2013 cell cycle development DNA replication origin of replication replication stress S-phase Genome duplication is an essential biological process that is tightly regulated and intricately co-ordinated with other cellular functions, including transcription, proliferation...