...Elizabeth B. Speltz; Rebecca S.H. Brown; Holly S. Hajare; Christian Schlieker; Lynne Regan Repeat proteins are an attractive target for protein engineering and design. We have focused our attention on the design and engineering of one particular class: tetratricopeptide repeat (TPR) proteins...

... for Huntingtin, elongation factor 3 (EF3), protein pphosphatase 2A (PP2A), yeast kinase Tor1) repeat proteins containing an α-helical repeated motif. The sequence of the repeated motifs, first identified in a thermostable archae protein was optimized using a consensus design strategy and used...

... equally to this work. 2 To whom correspondence should be addressed (email lynne.regan@yale.edu ). 17 6 2013 © 2013 The Authors 2013 alternative scaffold antibody molecular recognition protein design protein–protein interaction repeat protein An important goal...

...Ewan R.G. Main; Jonathan J. Phillips; Charlotte Millership There is enormous interest in molecular self-assembly and the development of biological systems to form smart nanostructures for biotechnology (so-called ‘bottom-up fabrications’). Repeat proteins are ideal choices for development...