... delivered stem cells engraft within lungs, thereby limiting their utility for airway repair. In other organ systems, magnetic targeting has shown promise for improving long-term robust cell engraftment. This technique involves in vitro cell expansion, magnetic actuation and magnetically guided cell...

... genome recombination Rep repair UvrD Helicases play essential roles in both the actual process of DNA replication and the repair or resuscitation of blocked replication forks. This class of enzymes use the energy derived from hydrolysis of nucleoside triphosphates (usually ATP) to translocate...

... The Authors Journal compilation © 2009 Biochemical Society 2009 archaeon Hel308 helicase recombination repair replication Since many stages of replication, repair and recombination require ssDNA (single-stranded DNA) substrates, helicases can oblige by separating strands of base-paired...

...E. Petermann; T. Helleday DNA lesions resulting from impaired progression of replication forks are implicated in genetic instability and tumorigenesis. Because the cellular response to these lesions poses an important tumorigenesis barrier, the responsible signalling and repair pathways are often...

...A.D. Metcalfe; M.W.J. Ferguson Biomedical science has made major advances in understanding how cells grow into functioning tissue and the signalling mechanisms used to achieve this are slowly being dissected. Tissue engineering is the application of that knowledge to the building or repairing...

... of Hmgn1 knockout mice and genetically engineered cell lines that are beginning to reveal the diverse roles that HMGN proteins play in DNA repair and transcription within mammalian cells. HMGN high-mobility-group N References 1 Bustin M. Trends Biochem. Sci. 2001 26 431 437...

... pyrimidine dimers (CPDs) and (6–4) photoproducts, can be very efficiently repaired by photoreactivation in this organism. There are two putative photolyase gene homologues in the published genome sequence of Halobacterium sp. NRC-1. We have made a mutant deleted in one of these, phr2 , and confirmed...