... cell states. In particular, we highlight their functions in the development of mammalian limbs, the inner ear, and craniofacial structure while discussing the genetic and biochemical evidence that showcases their conserved roles in tissue regeneration, disease, and cancer pathogenesis...

... maintenance. miRs as therapeutic reagents in tissue regeneration and repair hold great promise and new technologies are currently being designed to facilitate their expression or inhibition. Due to the large amount of miR research in cells and cancer many cellular processes and gene networks have been...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . planarian regeneration single-cell transcriptomics stem cells Single-cell transcriptomics is a recently developed technology [ 1 ]. However, it has experienced an exponential evolution...

... a positive influence on peripheral nerve regeneration, thereby enabling more effective nerve repair. 1 To whom correspondence should be addressed (email paul.kingham@umu.se ). Table 2 Neurotrophic factors and their roles following nerve injury Data taken from Allodi et al. [ 4...

...Jeremy P. Brockes; Phillip B. Gates Limb regeneration in adult salamanders proceeds by formation of a mound of progenitor cells called the limb blastema. It provides several pointers for regenerative medicine. These include the role of differentiated cells in the origin of the blastema, the role...

... myocardial regeneration and neovascularization. Autologous cell transplantation of a variety of adult progenitor cells has been taken forward in clinical trials and, in parallel, investigators have begun to focus on the activation of resident cardiac cell populations as a means to stimulate endogenous repair...

... of regenerative biology. For the purpose of this summary, we will concentrate primarily on the latter of these two approaches in that we have identified a novel mouse mutant that completely and perfectly regenerates skin and cartilaginous components following ear injury. This experimental animal will allow us...