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Keywords: recombination
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Articles
Biochem Soc Trans (2022) 50 (4): 1179–1186.
Published: 28 July 2022
... in number to 1–3 per chromosome pair that are predominantly located towards the chromosome ends. This reduces the probability of advantageous traits recombining onto the same chromosome, thus limiting breeding. Therefore, understanding the underlying factors controlling meiotic recombination may provide...
Articles
Biochem Soc Trans (2013) 41 (6): 1706–1711.
Published: 20 November 2013
... centromere chromosome heterochromatin fission yeast loss of heterozygosity (LOH) recombination Schizosaccharomyces pombe Swi6 Certain cancer cells, particularly solid tumours, are known for dramatic CIN (chromosome instability) phenotypes. Aneuploidy and other numerical disruptions (nCIN...
Articles
Biochem Soc Trans (2013) 41 (2): 595–600.
Published: 21 March 2013
...-terminus also interacts with the XerCD site-specific recombinases which act at the dif site, located in the terminus region. The motor domain of FtsK is an active translocase in vitro , and, when incubated with XerCD and a supercoiled plasmid containing two dif sites, recombination occurs to give unlinked...
Articles
Biochem Soc Trans (2013) 41 (1): 458–462.
Published: 29 January 2013
... patterns of natural variation that can be tested in the laboratory when combined with a diversity of natural variants and versatile genetic markers. We review how this approach has highlighted the importance of recombination as an evolutionary parameter and provided insight into a molecular mechanism...
Articles
Biochem Soc Trans (2011) 39 (2): 606–610.
Published: 22 March 2011
... genome recombination Rep repair UvrD Helicases play essential roles in both the actual process of DNA replication and the repair or resuscitation of blocked replication forks. This class of enzymes use the energy derived from hydrolysis of nucleoside triphosphates (usually ATP) to translocate...
Articles
Biochem Soc Trans (2011) 39 (1): 111–115.
Published: 19 January 2011
... systems in archaea are generally more similar to those in eukaryotes than those in bacteria, the order Methanococcales has a unique complement of DNA replication proteins, with multiple MCM (minichromosome maintenance) proteins and no obvious originbinding protein. A search for homologues of recombination...
Articles
Biochem Soc Trans (2010) 38 (6): 1676–1680.
Published: 24 November 2010
...Anna A. Torgasheva; Pavel M. Borodin Inversion heterozygotes are expected to suffer from reduced fertility and a high incidence of chromosomally unbalanced gametes due to recombination within the inverted region. Non-homologous synapsis of the inverted regions can prevent recombination...
Articles
Biochem Soc Trans (2010) 38 (2): 384–387.
Published: 22 March 2010
...Phoebe A. Rice; Kent. W. Mouw; Sherwin P. Montaño; Martin R. Boocock; Sally-J. Rowland; W. Marshall Stark A remarkable feature of the serine resolvases is their regulation: the wild-type enzymes will catalyse intra- but not inter-molecular recombination, can sense the relative orientation...
Articles
Biochem Soc Trans (2009) 37 (3): 589–595.
Published: 20 May 2009
... maintenance mechanism), either expression of telomerase or activation of the ALT (alternative lengthening of telomeres) pathway. Activation of the ALT mechanism results in deregulation of recombination-based activities at telomeres. Thus ALT+ cells show elevated T-SCE (telomere sister-chromatid exchange...
Articles
Biochem Soc Trans (2009) 37 (1): 74–78.
Published: 20 January 2009
... molecular biology of Hel308, drawing together ideas of how it may contribute to genome stability through the control of recombination, with reference to paradigms developed in bacteria. archaeon Hel308 helicase recombination repair replication Since many stages of replication, repair...
Articles
Biochem Soc Trans (2009) 37 (1): 97–101.
Published: 20 January 2009
... progress in understanding recombination events of exogenous DNA into the chromosomes of Sulfolobus solfataricus and Sulfolobus acidocaldarius and their application in the construction of targeted-deletion mutant strains. 1 To whom correspondence should be addressed (email albers@mpi-marburg.mpg.de...
Articles
Biochem Soc Trans (2006) 34 (4): 578–580.
Published: 21 July 2006
...S.L. Sherman; N.E. Lamb; E. Feingold Advancing maternal age has long been identified as the primary risk factor for human chromosome trisomy. More recently, altered patterns of meiotic recombination have been found to be associated with non-disjunction. We have used trisomy 21 as a model for human...
Articles
Biochem Soc Trans (2006) 34 (4): 535–536.
Published: 21 July 2006
...C.C.A. Spencer Meiotic recombination in humans is thought to occur as part of the resolution of DSBs (double-strand breaks). The repair of DSBs potentially leads to biases in DNA repair that can distort the population frequency of the alleles at single-nucleotide polymorphisms. Genome-wide...
Articles
Biochem Soc Trans (2006) 34 (4): 519–522.
Published: 21 July 2006
...S.P. Otto; A.C. Gerstein One of the greatest puzzles in evolutionary biology is the high frequency of sexual reproduction and recombination. Given that individuals surviving to reproductive age have genomes that function in their current environment, why should they risk shuffling their genes...
Articles
Biochem Soc Trans (2006) 34 (4): 581–582.
Published: 21 July 2006
... to multiple processes that create considerable heterogeneity. Genetic evidence suggests that meiotic recombination within telomeres is rare. However, there are various lines of evidence that implicate the involvement of intra-allelic processes in human telomere dynamics. In this paper, we briefly review some...
Articles
Biochem Soc Trans (2006) 34 (4): 574–577.
Published: 21 July 2006
...P.A. Hunt By comparison with other species, the meiotic process in the human female is extraordinarily error-prone. In addition to the well-known effect of advancing maternal age, recent studies have demonstrated that the number and location of meiotic recombination events influences the likelihood...
Articles
Biochem Soc Trans (2006) 34 (4): 526–530.
Published: 21 July 2006
...S. Myers; C.C.A. Spencer; A. Auton; L. Bottolo; C. Freeman; P. Donnelly; G. McVean Using the statistical analysis of genetic variation, we have developed a high-resolution genetic map of recombination hotspots and recombination rate variation across the human genome. This map, which has...
Articles
Biochem Soc Trans (2006) 34 (4): 545–549.
Published: 21 July 2006
... linked. Linkage of homologous chromosomes occurs during G 2 ; in cytological terms this stage is known as prophase I ( Figure 1 ). In most organisms including humans, three co-ordinated events occur during prophase I that ensure this linkage, namely homologous chromosome pairing, recombination...
Articles
Biochem Soc Trans (2006) 34 (4): 531–534.
Published: 21 July 2006
...C. Mézard Many studies have demonstrated that the distribution of meiotic crossover events along chromosomes is non-random in plants and other species with sexual reproduction. Large differences in recombination frequencies appear at several scales. On a large scale, regions of high and low rates...
Articles
Biochem Soc Trans (2004) 32 (6): 957–958.
Published: 26 October 2004
... cancer DNA repair helicase recombination topoisomerase The RecQ family of DNA helicases has received considerable interest due to their putative roles in suppression of cancer and premature ageing in humans [ 1 ]. Mutations in three different human RecQ helicase genes cause BS (Bloom's syndrome...
Articles
Biochem Soc Trans (2003) 31 (3): 706–710.
Published: 01 June 2003
...T. Allers; H.-P. Ngo Homologous recombination is a fundamental cellular process that rearranges genes both within and between chromosomes, promotes repair of damaged DNA and underpins replication. Much of our understanding of recombination stems from pioneering studies of bacterial and eukaryotic...
Articles
Biochem Soc Trans (2001) 29 (4): 442–446.
Published: 01 August 2001
.... Several mutants inactivated in mitochondrial genes encoding components of the respiratory complexes I, III and IV have been characterized at the molecular level. Assembly of complex I in several mutant strains and mapping of mitochondrial mutations by recombinational analysis are also described. 1...