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Keywords: receptor tyrosine kinase
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Biochem Soc Trans (2016) 44 (2): 363–370.
Published: 11 April 2016
...Thivyan Thayaparan; James F. Spicer; John Maher Malignant mesothelioma is an asbestos-related cancer that occurs most commonly in the pleural space and is incurable. Increasing evidence suggests that aberrant receptor tyrosine kinase (RTK)-directed signalling plays a key role in the pathogenesis...
Biochem Soc Trans (2013) 41 (4): 1029–1036.
Published: 18 July 2013
...Jeannine M. Mendrola; Fumin Shi; Jin H. Park; Mark A. Lemmon As with other groups of protein kinases, approximately 10% of the RTKs (receptor tyrosine kinases) in the human proteome contain intracellular pseudokinases that lack one or more conserved catalytically important residues. These include...
Biochem Soc Trans (2012) 40 (1): 195–199.
Published: 19 January 2012
.... 1 email aislyn.wist@mssm.edu 24 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cancer epidermal growth factor receptor (EGFR) ErbB juxtamembrane domain receptor tyrosine kinase EGF (epidermal growth factor) and its corresponding receptor...
Biochem Soc Trans (2011) 39 (6): 1583–1591.
Published: 21 November 2011
... and particularly an emerging role in signalling by other growth factor ligands for RTKs (receptor tyrosine kinases) such as HGF (hepatocyte growth factor) and PDGF (platelet-derived growth factor). It is uncertain, however, whether the model of NRP1–RTK heterocomplex formation applies in all of these situations...
Biochem Soc Trans (2009) 37 (6): 1193–1197.
Published: 19 November 2009
...Alexander F. Bruns; Leyuan Bao; John H. Walker; Sreenivasan Ponnambalam The mammalian endothelium expresses two related but distinct receptor tyrosine kinases, VEGFR1 and VEGFR2 [VEGF (vascular endothelial growth factor) receptor 1 and 2], that regulate the vascular response to a key cytokine, VEGF...
Biochem Soc Trans (2006) 34 (3): 414–417.
Published: 22 May 2006
...L.E. Kemp; B. Mulloy; E. Gherardi The receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration. Aberrant signalling of this complex is also a feature of many tumours...
Biochem Soc Trans (2003) 31 (6): 1445–1446.
Published: 01 December 2003
... differences in the N-terminal region may be responsible for functional divergence. The role of Sprouty in RTK (receptor tyrosine kinase) signalling pathways is still controversial. Sprouty may negatively or positively regulate RTK signalling via differential interaction with different signalling molecules...