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Keywords: receptor activation
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Articles
Biochem Soc Trans (2007) 35 (4): 709–712.
Published: 20 July 2007
... Society 2007 G-protein-coupled receptor (GPCR) ligand binding mutagenesis photoaffinity labelling receptor activation secretin receptor Fluorescence techniques can provide complementary insights into the environment of indicators that can be situated at distinct sites throughout...
Articles
Biochem Soc Trans (2007) 35 (4): 729–732.
Published: 20 July 2007
...A.C. Conner; J. Simms; J. Barwell; M. Wheatley; D.R. Poyner The receptor for CGRP (calcitonin gene-related peptide) is a heterodimer between a GPCR (G-protein-coupled receptor), CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity-modifying protein 1). Models...
Articles
Biochem Soc Trans (2007) 35 (4): 707–708.
Published: 20 July 2007
... articles. 11 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 drug design G-protein-coupled receptor (GPCR) ligand binding molecular modelling receptor activation This following collection of articles are based on talks given at the Biochemical Society...
Articles
Biochem Soc Trans (2007) 35 (4): 717–720.
Published: 20 July 2007
... that these extracellular domains fulfil a range of important roles with respect to GPCR signalling, including agonist binding, ligand selectivity and receptor activation. AVP [Arg 8 ]vasopressin bRho bovine rhodopsin ECL extracellular loop GPCR G-protein-coupled receptor OT oxytocin OTR...
Articles
Biochem Soc Trans (2004) 32 (6): 1048–1050.
Published: 26 October 2004
... fulfil a range of important roles with respect to GPCR signalling, including agonist binding, ligand selectivity and receptor activation. 23 7 2004 © 2004 The Biochemical Society 2004 1 To whom correspondence should be addressed (email m.wheatley@bham.ac.uk ). The role of ECL3...
Articles
Biochem Soc Trans (2004) 32 (6): 1037–1039.
Published: 26 October 2004
... recognize, stabilize and increase the R* population, thus altering intracellular activity. There is evidence to suggest the possibility of a spectrum of conformations between R and R*. Our aim is to study the consequences of putative GR (glucagon receptor)-activating mutations using glucagon and partial...
Articles
Biochem Soc Trans (2003) 31 (1): 35–39.
Published: 01 February 2003
... mutagenesis revealed that a single residue (Arg 46 ) was critical for agonist binding and receptor activation. The N-terminus of the related OT receptor (OTR) could recover agonist binding in a chimaeric OTR N –V 1a R construct. Furthermore, Arg 34 of the human OTR, which corresponds to Arg 46 of the rat V 1a...