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Keywords: receptor
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Biochem Soc Trans (2018) 46 (2): 391–401.
Published: 14 March 2018
...Lisa M. Ebert; Wenbo Yu; Tessa Gargett; Michael P. Brown Chimeric antigen receptor (CAR)-T cell therapy has been clinically validated as a curative treatment for the difficult to treat malignancies of relapsed/refractory B-cell acute lymphoblastic leukaemia and lymphoma. Here, the CAR-T cells...
Biochem Soc Trans (2012) 40 (6): 1463–1468.
Published: 21 November 2012
...Stanislav D. Zakharov; Onkar Sharma; Mariya Zhalnina; Eiki Yamashita; William A. Cramer Pathway I. Group A nuclease colicins parasitize and bind tightly ( K d ≤ 10 −9 M) to the vitamin B 12 receptor on which they diffuse laterally in the OM (outer membrane) and use their long (≥100 Å; 1 Å=0.1 nm...
Biochem Soc Trans (2010) 38 (4): 919–922.
Published: 26 July 2010
... in the extracellular environment, especially those made by membrane-embedded receptor proteins. In the present article, we discuss some of our recent research in the development of a scalable assay to identify this class of protein interaction and some of the findings from its application in the construction...
Biochem Soc Trans (2010) 38 (3): 807–816.
Published: 24 May 2010
... on the targeting signal within the protein. Each pathway has a specific receptor but utilizes common membrane-bound translocation machinery. Current models invoke receptor recycling, which may involve cycles of ubiquitination. Some components of the import machinery may also play a role in proteolytic turnover...
Biochem Soc Trans (2009) 37 (6): 1317–1322.
Published: 19 November 2009
... receptors for these neurotransmitters have attracted so much attention as potential targets for the promotion of health and the treatment of disease. Indeed, dysfunction of these receptors underlies a number of well-characterized neuropathological conditions such as anxiety, epilepsy and neurodegenerative...
Biochem Soc Trans (2004) 32 (5): 888–891.
Published: 26 October 2004
...J. Presland Historically, the activation and inhibition of GPCR (G-protein-coupled receptor) function have been a very successful avenue for drug discovery and development. However, it is clear that receptors do not function in isolation but are impacted by other proteins. These proteins may alter...
Biochem Soc Trans (2003) 31 (5): 1020–1027.
Published: 01 October 2003
... generated by fusions of visible fluorescence proteins, as exemplified by studies of the erbB receptor tyrosine kinases involved in growth-factor-mediated signal transduction. 1 Permanent address: Department of Chemistry, Colorado State University, Fort Collins, CO 80525, U.S.A. 2 Present...
Biochem Soc Trans (2001) 29 (4): 525–529.
Published: 01 August 2001
...D. J. Withers A family of insulin receptor substrate (IRS) proteins mediates the pleiotropic effects of insulin and insulin-like growth factor 1 (IGF-1) on cellular function by recruiting several intracellular signalling networks. Conventional murine knockout strategies have started to reveal...