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Articles

Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?

Giulio Laurenti, Daniel A. Tennant

Biochem Soc Trans (2016) 44 (4): 1111–1116.

DOI: https://doi.org/10.1042/BST20160099

Published: 15 August 2016

... Society 2016 cancer metabolism fumarate hydratase hypoxia isocitrate dehydrogenase reactive oxygen species (ROS) succinate dehydrogenase Of the three enzymes described above, the most commonly mutated in cancer is thought to be IDH1 and IDH2. Mutations in these enzymes were first shown...

View article titled, Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?

Articles

Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention

Bryan Harder, Tao Jiang, Tongde Wu, Shasha Tao, Montserrat Rojo de la Vega, Wang Tian, Eli Chapman, Donna D. Zhang

Biochem Soc Trans (2015) 43 (4): 680–686.

DOI: https://doi.org/10.1042/BST20150020

Published: 03 August 2015

... (email dzhang@pharmacy.arizona.edu ) . 9 2 2015 © 2015 Authors; published by Portland Press Limited 2015 chemoprevention/chemoresistance Hrd1 Kelch-like ECH-associated protein 1 (Keap1) nuclear factor erytheroid-derived-2-like 2 (Nrf2) reactive oxygen species (ROS) ubiquitin...

View article titled, Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention

Articles

Thioredoxin as a putative biomarker and candidate target in age-related immune decline

Helen R. Griffiths, Stuart J. Bennett, Peter Olofsson, Christopher R. Dunston

Biochem Soc Trans (2014) 42 (4): 922–927.

DOI: https://doi.org/10.1042/BST20140162

Published: 11 August 2014

... for lifespan and immune function. 1 To whom correspondence should be addressed (email h.r.griffiths@aston.ac.uk ). 2 6 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 ageing oxidation reactive oxygen species (ROS) rheumatoid arthritis thiol thioredoxin...

View article titled, Thioredoxin as a putative biomarker and candidate target in age-related immune decline

Articles

ROS signalling, NADPH oxidases and cancer

William D. Landry, Thomas G. Cotter

Biochem Soc Trans (2014) 42 (4): 934–938.

DOI: https://doi.org/10.1042/BST20140060

Published: 11 August 2014

... correspondence should be addressed (email t.cotter@ucc.ie ). 31 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer hydrogen peroxide (H 2 O 2 ) NADPH oxidase (Nox) reactive oxygen species (ROS) signalling Generation of ROS (reactive oxygen species) has...

View article titled, ROS signalling, NADPH oxidases and cancer

Articles

Aberrant redox homoeostasis and mitochondrial dysfunction in Rett syndrome

Michael Müller, Karolina Can

Biochem Soc Trans (2014) 42 (4): 959–964.

DOI: https://doi.org/10.1042/BST20140071

Published: 11 August 2014

... oxygen species (ROS) redox imaging RTT (Rett syndrome) was initially described in 1966 as an “unusual brain atrophy syndrome” [ 1 , 2 ]. It primarily affects girls with a prevalence of 1:10000–15000, and is associated with severe cognitive impairment. Typically, RTT progresses in four stages...

View article titled, Aberrant redox homoeostasis and mitochondrial dysfunction in Rett syndrome

Articles

Self-incompatibility in Papaver : advances in integrating the signalling network

Deborah J. Eaves, Carlos Flores-Ortiz, Tamanna Haque, Zongcheng Lin, Nianjun Teng, Vernonica E. Franklin-Tong

Biochem Soc Trans (2014) 42 (2): 370–376.

DOI: https://doi.org/10.1042/BST20130248

Published: 20 March 2014

... (NO) Papaver pollen programmed cell death (PCD) reactive oxygen species (ROS) self-incompatibility Successful sexual reproduction in many flowering plants involves a genetically controlled mechanism called SI (self-incompatibility). SI is genetically controlled by a multi-allelic S -locus...

View article titled, Self-incompatibility in Papaver : advances in integrating the signalling network

Articles

Rethinking the clockwork: redox cycles and non-transcriptional control of circadian rhythms

Lisa Wu, Akhilesh B. Reddy

Biochem Soc Trans (2014) 42 (1): 1–10.

DOI: https://doi.org/10.1042/BST20130169

Published: 23 January 2014

... be addressed (email areddy@cantab.net ). 14 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 circadian rhythm peroxiredoxin reactive oxygen species (ROS) redox homoeostasis Circadian rhythms are arguably one of life's most basic mechanisms, regulating...

View article titled, Rethinking the clockwork: redox cycles and non-transcriptional control of circadian rhythms

Articles

Prion processing: a double-edged sword?

Hilary E.M. McMahon

Biochem Soc Trans (2012) 40 (4): 735–738.

DOI: https://doi.org/10.1042/BST20120031

Published: 20 July 2012

... cleavage Creutzfeldt–Jakob disease octapeptide repeat prion processing reactive oxygen species (ROS) As for numerous proteins, the endogenous PrP C (normal cellular prion protein) undergoes a number of post-translational cleavage events during its life. The main cleavage processes are so...

View article titled, Prion processing: a double-edged sword?

Articles

Cell migration and invasion in human disease: the Tks adaptor proteins

Sara A. Courtneidge

Biochem Soc Trans (2012) 40 (1): 129–132.

DOI: https://doi.org/10.1042/BST20110685

Published: 19 January 2012

... compilation © 2012 Biochemical Society 2012 atherosclerosis cancer embryonic development reactive oxygen species (ROS) Podosomes and invadopodia can be defined as dynamic actin-rich protrusions of the ventral membrane of certain cell types [ 1 ]. They are the sites of attachment...

View article titled, Cell migration and invasion in human disease: the Tks adaptor proteins

Articles

Nuclear Envelope Disease and Chromatin Organization

Juliet A. Ellis, Sue Shackleton

Biochem Soc Trans (2011) 39 (6): 1683–1686.

DOI: https://doi.org/10.1042/BST20110744

Published: 21 November 2011

... chromatin organization Emery–Dreifuss muscular dystrophy (EDMD) Hutchinson–Gilford progeria syndrome (HGPS) induced pluripotent stem cell (iPSC) nuclear envelope disease reactive oxygen species (ROS) The Nuclear Envelope Disease and Chromatin Organization UK was formed in 2005, to unite...

View article titled, Nuclear Envelope Disease and Chromatin Organization

Articles

The role of DNA damage in laminopathy progeroid syndromes

Christopher J. Hutchison

Biochem Soc Trans (2011) 39 (6): 1715–1718.

DOI: https://doi.org/10.1042/BST20110700

Published: 21 November 2011

... © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA damage response Hutchinson–Gilford progeria syndrome (HGPS) lamin laminopathy progeria reactive oxygen species (ROS) The progeroid laminopathies include HGPS (Hutchinson–Gilford progeria syndrome), atypical...

View article titled, The role of DNA damage in laminopathy progeroid syndromes

Articles

Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans

Taísa Magnani Dinamarco, Maria Helena S. Goldman, Gustavo Henrique Goldman

Biochem Soc Trans (2011) 39 (5): 1544–1548.

DOI: https://doi.org/10.1042/BST0391544

Published: 21 September 2011

View article titled, Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans

Articles

Electrochemical and optical sensing of reactive oxygen species: pathway to an integrated intracellular and extracellular measurement platform

Philip Manning, Calum J. McNeil

Biochem Soc Trans (2011) 39 (5): 1288–1292.

DOI: https://doi.org/10.1042/BST0391288

Published: 21 September 2011

... a variety of species [e.g. peroxynitrite (ONOO – ) and hydroxyl radicals (OH • )] that are highly damaging to biomolecules. electrochemical detection isolated mitochondrion macrophage optical nanosensor reactive oxygen species (ROS) superoxide dismutase (SOD) © The Authors Journal...

View article titled, Electrochemical and optical sensing of reactive oxygen species: pathway to an integrated intracellular and extracellular measurement platform

Articles

Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?

Irina G. Shabalina, Jan Nedergaard

Biochem Soc Trans (2011) 39 (5): 1305–1309.

DOI: https://doi.org/10.1042/BST0391305

Published: 21 September 2011

... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...

View article titled, Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?

Articles

Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species

Balaraman Kalyanaraman

Biochem Soc Trans (2011) 39 (5): 1221–1225.

DOI: https://doi.org/10.1042/BST0391221

Published: 21 September 2011

... dichlorodihydrofluorescein or dihydrorhodamine. 1 email balarama@mcw.edu . 15 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide...

View article titled, Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species

Articles

Aging and longevity of yeast colony populations: metabolic adaptation and differentiation

Libuše Váchová, Zdena Palková

Biochem Soc Trans (2011) 39 (5): 1471–1475.

DOI: https://doi.org/10.1042/BST0391471

Published: 21 September 2011

... signalling quorum sensing reactive oxygen species (ROS) stress defence and dying yeast colony architecture and differentiation Most knowledge of yeast cell reproduction, aging and dying comes from laboratory investigations, where cells are often treated in liquid cultures grown under various...

View article titled, Aging and longevity of yeast colony populations: metabolic adaptation and differentiation

Articles

Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease

Paul G. Winyard, Brent Ryan, Paul Eggleton, Ahuva Nissim, Emma Taylor, Maria Letizia Lo Faro, Torsten Burkholz, Katalin E. Szabó-Taylor, Bridget Fox, Nick Viner, Richard C. Haigh, Nigel Benjamin, Andrew M. Jones, Matthew Whiteman

Biochem Soc Trans (2011) 39 (5): 1226–1232.

DOI: https://doi.org/10.1042/BST0391226

Published: 21 September 2011

... 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 advanced glycation end-product (AGE) reactive nitrogen species (RNS) reactive oxygen species (ROS) reactive sulfur species (RSS) rheumatoid arthritis (RA) RA (rheumatoid arthritis) is an inflammatory...

View article titled, Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease

Articles

Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Helen R. Griffiths, Christopher R. Dunston, Stuart J. Bennett, Melissa M. Grant, Darren C. Phillips, George D. Kitas

Biochem Soc Trans (2011) 39 (5): 1273–1278.

DOI: https://doi.org/10.1042/BST0391273

Published: 21 September 2011

... 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ageing glutathione inflammation reactive oxygen species (ROS) redox signalling regulatory T-cell (T reg cell) The principal function of the immune system is to discriminate between self and non-self...

View article titled, Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Articles

Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Nicoletta Guaragnella, Lucia Antonacci, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio

Biochem Soc Trans (2011) 39 (5): 1538–1543.

DOI: https://doi.org/10.1042/BST0391538

Published: 21 September 2011

... cytochrome c mitochondrion programmed cell death (PCD) reactive oxygen species (ROS) Saccharomyces cerevisiae YCA1 The term PCD (programmed cell death) describes a highly heterogeneous process regulated by distinct but sometimes overlapping pathways including apoptosis, autophagic cell death...

View article titled, Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Articles

The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress

Ning Li, Francesca Frigerio, Pierre Maechler

Biochem Soc Trans (2008) 36 (5): 930–934.

DOI: https://doi.org/10.1042/BST0360930

Published: 19 September 2008

... ). 8 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 diabetes lipotoxicity mitochondrial DNA (mtDNA) oxidative stress pancreatic β-cell reactive oxygen species (ROS) Pancreatic β-cells are poised to sense glucose and other nutrient secretagogues...

View article titled, The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress

Articles

The production of reactive oxygen species by complex I

Judy Hirst, Martin S. King, Kenneth R. Pryde

Biochem Soc Trans (2008) 36 (5): 976–980.

DOI: https://doi.org/10.1042/BST0360976

Published: 19 September 2008

... mitochondrion NADH:ubiquinone oxidoreductase oxidative stress reactive oxygen species (ROS) reverse electron transport The electron transport chain in mitochondria is a significant source of cellular ROS. Historically, respiratory complexes I and III have been considered two major sources...

View article titled, The production of reactive oxygen species by complex I

Articles

Exploring the role of protein phosphorylation in plants: from signalling to metabolism

S.C. Huber

Biochem Soc Trans (2007) 35 (1): 28–32.

DOI: https://doi.org/10.1042/BST0350028

Published: 22 January 2007

... The Biochemical Society 2007 nitrate plant metabolism protein phosphorylation photosynthesis reactive oxygen species (ROS) sucrose phosphate synthase (SPS) This review focuses on phosphorylation and signalling in plants. It takes quite a broad overview of the subject, but, within...

View article titled, Exploring the role of protein phosphorylation in plants: from signalling to metabolism

Articles

What else has to happen for nitric oxide to induce cell death?

V. Borutaite, G. Brown

Biochem Soc Trans (2005) 33 (6): 1394–1396.

DOI: https://doi.org/10.1042/BST0331394

Published: 26 October 2005

... factors including, particularly oxygen, superoxide, H 2 O 2 , antioxidants, thiols and glycolysis. apoptosis hypoxia necrosis nitric oxide (NO) reactive oxygen species (ROS) superoxide production NO is an important regulator of cell viability and death depending on its concentration...

View article titled, What else has to happen for nitric oxide to induce cell death?

Articles

Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium

J.W. Zmijewski, A. Landar, N. Watanabe, D.A. Dickinson, N. Noguchi, V.M. Darley-Usmar

Biochem Soc Trans (2005) 33 (6): 1385–1389.

DOI: https://doi.org/10.1042/BST0331385

Published: 26 October 2005

...) lysophosphatidylcholine mitochondrion oxidized lipid reactive oxygen species (ROS) thiol The formation of low molecular mass second messengers as cell-signalling molecules is well established in the redox cell-signalling field. The molecules involved in signalling are structurally diverse and include the ROS...

View article titled, Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium

Articles

Reactive oxygen species (ROS)-mediated β-cleavage of the prion protein in the mechanism of the cellular response to oxidative stress

N.T. Watt, N.M. Hooper

Biochem Soc Trans (2005) 33 (5): 1123–1125.

DOI: https://doi.org/10.1042/BST0331123

Published: 26 October 2005

... prion protein (PrP) proteolysis reactive oxygen species (ROS) Prion diseases occur when a conformational conversion in the normal PrP C [cellular isoform of PrP (prion protein)] produces a proteinase-resistant form PrP Sc (scrapie isoform of PrP). Examples of such neurodegenerative disorders...

View article titled, Reactive oxygen species (ROS)-mediated β-cleavage of the prion protein in the mechanism of the cellular response to oxidative stress

Articles

Before and beyond ABA: upstream sensing and internal signals that determine ABA accumulation and response under abiotic stress

P.E. Verslues, J.-K. Zhu

Biochem Soc Trans (2005) 33 (2): 375–379.

DOI: https://doi.org/10.1042/BST0330375

Published: 01 April 2005

....-K. Zhu, unpublished work). abiotic stress abscisic acid (ABA) osmoregulation reactive oxygen species (ROS) upstream sensing upstream signalling Several lines of experiments will be needed to obtain a better understanding of the ABA–ROS interaction. The genes that are responsible...

View article titled, Before and beyond ABA: upstream sensing and internal signals that determine ABA accumulation and response under abiotic stress

Articles

Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions

K.G. Lyamzaev, O.Y. Pletjushkina, V.B. Saprunova, L.E. Bakeeva, B.V. Chernyak, V.P. Skulachev

Biochem Soc Trans (2004) 32 (6): 1070–1071.

DOI: https://doi.org/10.1042/BST0321070

Published: 26 October 2004

... related to energy saving and apoptosis requires careful study. elimination of mitochondria fission fusion mitochondrial inhibitors reactive oxygen species (ROS) © 2004 The Biochemical Society 2004 19 7 2004 1 To whom correspondence should be addressed (email bchernyak...

View article titled, Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions

Articles

Redox regulation of phosphatase function

N.R. Leslie, Y. Lindsay, S.H. Ross, C.P. Downes

Biochem Soc Trans (2004) 32 (6): 1018–1020.

DOI: https://doi.org/10.1042/BST0321018

Published: 26 October 2004

... oxygen species (ROS) redox signalling superoxide Regulated reversible phosphorylation of proteins and other cellular molecules plays a ubiquitous role in the control of cellular behaviour. Several different classes of enzymes have evolved that catalyse the removal of phosphate from different...

View article titled, Redox regulation of phosphatase function

Articles

Reactive oxygen species in oncogenic transformation

L. Behrend, G. Henderson, R.M. Zwacka

Biochem Soc Trans (2003) 31 (6): 1441–1444.

DOI: https://doi.org/10.1042/bst0311441

Published: 01 December 2003

... of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 9 July 2003 © 2003 Biochemical Society 2003 apoptosis growth factor Mn superoxide dismutase Ras reactive oxygen species (ROS) senescence Abbreviations used: AP-1, activator protein-1; DPI...

View article titled, Reactive oxygen species in oncogenic transformation

NARROW

Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?

Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention

Thioredoxin as a putative biomarker and candidate target in age-related immune decline

ROS signalling, NADPH oxidases and cancer

Aberrant redox homoeostasis and mitochondrial dysfunction in Rett syndrome

Self-incompatibility in Papaver : advances in integrating the signalling network

Rethinking the clockwork: redox cycles and non-transcriptional control of circadian rhythms

Prion processing: a double-edged sword?

Cell migration and invasion in human disease: the Tks adaptor proteins

Nuclear Envelope Disease and Chromatin Organization

The role of DNA damage in laminopathy progeroid syndromes

Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans

Electrochemical and optical sensing of reactive oxygen species: pathway to an integrated intracellular and extracellular measurement platform

Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?

Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species

Aging and longevity of yeast colony populations: metabolic adaptation and differentiation

Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease

Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress

The production of reactive oxygen species by complex I

Exploring the role of protein phosphorylation in plants: from signalling to metabolism

What else has to happen for nitric oxide to induce cell death?

Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium

Reactive oxygen species (ROS)-mediated β-cleavage of the prion protein in the mechanism of the cellular response to oxidative stress

Before and beyond ABA: upstream sensing and internal signals that determine ABA accumulation and response under abiotic stress

Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions

Redox regulation of phosphatase function

Reactive oxygen species in oncogenic transformation

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